Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC38 | Torin2 | 3 | 72 | sigmoid | sigmoid | HCC38 Torin2 0 3 72 | 8 | 1.385 | 0.013 | -0.624 | 0.855 | 0.0547 | -0.706 | 0.615 | 0.996 | 8.13e-08 | NA | 0.0407 | 0.0986 | 0.484 | 0.0311 | 0.0829 | 0.669 | 0.997 | 3.31e-08 | NA |
HCC38 | AZD8055 | 1 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 1 72 | 8 | 1.773 | 0.052 | 0.151 | 0.479 | 0.0381 | 0.136 | 1.02 | 0.992 | 4.28e-07 | NA | 0.116 | 0.375 | 0.633 | 0.0313 | 0.363 | 0.987 | 0.993 | 3.89e-07 | NA |
HCC38 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 2 72 | 8 | 2.128 | 0.0616 | 0.16 | 0.467 | 0.045 | 0.124 | 0.912 | 0.993 | 3.13e-07 | NA | 0.0875 | 0.314 | 0.594 | 0.0332 | 0.284 | 0.869 | 0.991 | 6.5e-07 | NA |
HCC1806 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 3 72 | 8 | 3.242 | Inf | 0.531 | 0.255 | 0.0458 | 0.517 | 0.885 | 0.997 | 3.48e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC1806 | WYE-125132 | 2 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 2 72 | 8 | 2.874 | 0.872 | 0.479 | 0.284 | 0.045 | 0.464 | 0.883 | 0.997 | 3.66e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC1806 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 1 72 | 8 | 2.790 | 0.603 | 0.466 | 0.292 | 0.0448 | 0.45 | 0.883 | 0.997 | 3.72e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
BT-20 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | BT20 WYE-132 0 1 72 | 8 | 2.067 | 0.0893 | 0.289 | 0.402 | 0.0435 | 0.256 | 1.0 | 0.987 | 2.28e-06 | NA | 0.154 | 0.403 | 0.647 | 0.0353 | 0.375 | 0.941 | 0.985 | 3.56e-06 | NA |
HCC38 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 3 72 | 8 | 1.417 | 0.0464 | 0.0327 | 0.53 | 0.0463 | 0.000983 | 1.04 | 0.997 | 4.27e-08 | NA | 0.157 | 0.392 | 0.658 | 0.041 | 0.372 | 1.02 | 0.996 | 5.78e-08 | NA |
HCC38 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | HCC38 WYE-132 0 1 72 | 8 | 1.708 | 0.0604 | 0.142 | 0.447 | 0.0481 | 0.134 | 1.36 | 0.997 | 3.43e-08 | NA | 0.115 | 0.384 | 0.669 | 0.0413 | 0.381 | 1.4 | 0.996 | 6.46e-08 | NA |
HCC1806 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 2 72 | 8 | 2.817 | Inf | 0.546 | 0.24 | 0.0517 | 0.535 | 1.19 | 0.995 | 1.31e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
HCC1806 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 3 72 | 8 | 3.185 | Inf | 0.593 | 0.215 | 0.0523 | 0.583 | 1.19 | 0.995 | 1.36e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
HCC1806 | AZD8055 | 1 | 72 | sigmoid | sigmoid | HCC1806 AZD8055 0 1 72 | 8 | 2.732 | Inf | 0.534 | 0.247 | 0.0515 | 0.522 | 1.19 | 0.995 | 1.3e-07 | NA | 0.521 | 0.484 | 0.716 | 0.0427 | 0.471 | 1.15 | 0.996 | 7.15e-08 | NA |
HCC38 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC38 WYE-132 0 3 72 | 8 | 1.449 | 0.0494 | -0.0216 | 0.518 | 0.0504 | -0.0117 | 1.18 | 0.998 | 9.69e-09 | NA | 0.128 | 0.355 | 0.662 | 0.0441 | 0.361 | 1.2 | 0.998 | 9.53e-09 | NA |
HCC1806 | Torin2 | 2 | 72 | sigmoid | sigmoid | HCC1806 Torin2 0 2 72 | 8 | 2.843 | 0.0589 | -0.181 | 0.57 | 0.0771 | -0.211 | 1.3 | 0.996 | 6.72e-08 | NA | 0.0486 | 0.079 | 0.492 | 0.0442 | 0.0528 | 1.17 | 0.995 | 1.08e-07 | NA |
HCC1806 | Torin2 | 1 | 72 | sigmoid | sigmoid | HCC1806 Torin2 0 1 72 | 8 | 2.759 | 0.0569 | -0.203 | 0.582 | 0.0763 | -0.234 | 1.3 | 0.996 | 6.76e-08 | NA | 0.0486 | 0.079 | 0.492 | 0.0442 | 0.0528 | 1.17 | 0.995 | 1.09e-07 | NA |
HCC1806 | Torin2 | 3 | 72 | sigmoid | sigmoid | HCC1806 Torin2 0 3 72 | 8 | 3.212 | 0.0678 | -0.0927 | 0.522 | 0.0798 | -0.12 | 1.32 | 0.996 | 6.56e-08 | NA | 0.0486 | 0.079 | 0.492 | 0.0442 | 0.0528 | 1.17 | 0.995 | 1.09e-07 | NA |
HCC38 | Omipalisib | 1 | 72 | sigmoid | sigmoid | HCC38 omipalisib 0 1 72 | 8 | 1.760 | 0.0231 | -0.316 | 0.672 | 0.152 | -0.638 | 0.438 | 0.97 | 2.61e-05 | NA | 0.0585 | 0.151 | 0.512 | 0.0499 | 0.0356 | 0.465 | 0.956 | 8.65e-05 | NA |
BT-20 | GDC-0980 | 2 | 72 | sigmoid | sigmoid | BT20 apitolisib 0 2 72 | 8 | 1.659 | 0.0456 | -0.414 | 0.639 | 0.0629 | -0.33 | 1.58 | 0.993 | 4.18e-07 | NA | 0.0641 | 0.131 | 0.575 | 0.0506 | 0.168 | 1.74 | 0.995 | 1.2e-07 | NA |
HCC38 | Omipalisib | 2 | 72 | sigmoid | sigmoid | HCC38 omipalisib 0 2 72 | 8 | 2.124 | 0.0404 | -0.47 | 0.634 | 0.45 | -1.0 | 0.456 | 0.979 | 9.71e-06 | NA | 0.0507 | 0.0595 | 0.494 | 0.0507 | 0.0 | 0.556 | 0.96 | 6.44e-05 | NA |
HCC1806 | Omipalisib | 1 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 1 72 | 8 | 2.764 | 0.104 | -0.333 | 0.49 | 0.508 | -0.746 | 0.577 | 0.98 | 8.23e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
HCC1806 | Omipalisib | 2 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 2 72 | 8 | 2.849 | 0.112 | -0.311 | 0.479 | 0.543 | -0.739 | 0.573 | 0.98 | 8.07e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
HCC1806 | Omipalisib | 3 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 3 72 | 8 | 3.217 | 0.147 | -0.221 | 0.437 | 0.71 | -0.707 | 0.559 | 0.981 | 7.41e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
BT-549 | Trametinib | 2 | 72 | sigmoid | sigmoid | BT549 trametinib 0 2 72 | 8 | 1.914 | Inf | 0.602 | 0.2 | 0.0685 | 0.581 | 0.837 | 0.995 | 1.05e-07 | NA | Inf | 0.654 | 0.822 | 0.0601 | 0.638 | 0.839 | 0.995 | 1.04e-07 | NA |
Hs 578T | MK2206 | 2 | sigmoid | sigmoid | Hs578T MK-2206 2 | 8 | 2.530 | Inf | 0.664 | 0.131 | 0.0699 | 0.752 | 1.34 | 0.75 | 0.0156 | NA | Inf | 0.628 | 0.848 | 0.0616 | 0.717 | 1.21 | 0.767 | 0.0126 | NA | |
HCC70 | Torin2 | 2 | 72 | sigmoid | sigmoid | HCC70 Torin2 0 2 72 | 8 | 1.826 | 0.0342 | -0.522 | 0.671 | 0.401 | -1.0 | 0.446 | 0.979 | 9.23e-06 | NA | 0.0639 | 0.0733 | 0.507 | 0.0639 | 0.0 | 0.462 | 0.969 | 2.98e-05 | NA |