Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-549	ZSTK474	3	72	sigmoid	sigmoid	BT549 ZSTK474 0 3 72	8	1.776	0.504	0.139	0.267	0.616	-0.0912	0.836	0.996	7.06e-08	NA	0.994	0.368	0.789	0.489	0.218	0.808	0.995	9.19e-08	NA
HCC38	PI103	1	72	sigmoid	sigmoid	HCC38 PI-103 0 1 72	8	1.782	0.755	0.222	0.201	0.601	0.12	1.2	0.996	4.45e-08	NA	1.39	0.416	0.839	0.494	0.359	1.23	0.995	1.01e-07	NA
HCC70	MK2206	1	72	sigmoid	sigmoid	HCC70 MK-2206 0 1 72	8	1.444	0.314	-0.0266	0.337	0.618	-0.336	0.758	0.991	6.35e-07	NA	0.925	0.353	0.775	0.521	0.172	0.737	0.99	1.08e-06	NA
HCC38	BX-912	1	72	sigmoid	sigmoid	HCC38 BX-912 0 1 72	8	1.760	0.529	-0.322	0.274	0.591	-0.322	4.49	0.999	1.36e-10	NA	0.584	0.149	0.818	0.541	0.149	4.63	0.999	8.39e-10	NA
Hs 578T	AS605240	3		sigmoid	sigmoid	Hs578T AS-605240 3	8	2.856	63.8	0.588	0.0965	0.826	0.494	1.03	0.983	4.89e-06	NA	5.75	0.518	0.879	0.552	0.465	1.14	0.981	6.87e-06	NA
HCC38	BX-912	2	72	sigmoid	sigmoid	HCC38 BX-912 0 2 72	8	2.186	0.583	-0.229	0.251	0.648	-0.233	3.62	0.999	9.58e-10	NA	0.602	0.124	0.807	0.559	0.123	3.78	0.998	1.03e-08	NA
HCC1806	AS605240	1	72	sigmoid	sigmoid	HCC1806 AS-605240 0 1 72	8	2.728	Inf	0.911	0.0128	0.569	0.91	2.8	0.936	0.000262	NA	Inf	0.883	0.983	0.559	0.882	2.81	0.931	0.000333	NA
HCC1806	AS605240	2	72	sigmoid	sigmoid	HCC1806 AS-605240 0 2 72	8	2.813	Inf	0.913	0.0124	0.569	0.913	2.8	0.936	0.000261	NA	Inf	0.883	0.983	0.559	0.882	2.81	0.931	0.000333	NA
HCC1806	AS605240	3	72	sigmoid	sigmoid	HCC1806 AS-605240 0 3 72	8	3.181	Inf	0.923	0.011	0.57	0.923	2.81	0.936	0.000257	NA	Inf	0.883	0.983	0.559	0.882	2.81	0.931	0.000333	NA
HCC38	Pictilisib	2	72	sigmoid	sigmoid	HCC38 pictilisib 0 2 72	8	2.112	Inf	0.622	0.0838	0.644	0.58	1.32	0.933	0.000298	NA	Inf	0.642	0.918	0.568	0.612	1.36	0.922	0.000475	NA
BT-20	PI103	1	72	sigmoid	sigmoid	BT20 PI-103 0 1 72	8	1.924	0.646	-0.0114	0.16	0.659	-0.0268	2.6	0.978	1.1e-05	NA	0.753	0.258	0.883	0.579	0.252	2.68	0.964	4.79e-05	NA
Hs 578T	ZSTK474	2		sigmoid	sigmoid	Hs578T ZSTK474 2	8	2.554	0.715	0.187	0.263	5.92	-0.896	0.485	0.995	1.27e-07	NA	0.583	0.264	0.722	0.583	0.0	0.56	0.993	3.28e-07	NA
Hs 578T	Buparlisib	1		sigmoid	sigmoid	Hs578T buparlisib 1	8	2.064	0.55	-0.579	0.308	1.29	-1.0	1.29	0.992	4.22e-07	NA	0.587	0.0401	0.759	0.587	0.0	1.31	0.988	1.94e-06	NA
BT-549	ZSTK474	2	72	sigmoid	sigmoid	BT549 ZSTK474 0 2 72	8	1.962	0.628	0.144	0.245	0.841	-0.139	0.84	0.995	1.29e-07	NA	0.958	0.334	0.791	0.595	0.163	0.828	0.992	4.28e-07	NA
Hs 578T	Buparlisib	2		sigmoid	sigmoid	Hs578T buparlisib 2	8	2.513	0.665	-0.42	0.251	1.61	-1.0	1.24	0.998	1.14e-08	NA	0.595	0.0445	0.779	0.595	0.0	1.36	0.994	2.48e-07	NA
BT-20	Buparlisib	3	72	sigmoid	sigmoid	BT20 buparlisib 0 3 72	8	2.529	0.629	-0.303	0.26	1.06	-0.565	1.46	0.994	2.13e-07	NA	0.603	0.0696	0.764	0.603	0.0	1.52	0.984	4.36e-06	NA
BT-20	Alpelisib	2	72	sigmoid	sigmoid	BT20 alpelisib 0 2 72	8	1.692	0.253	-0.0994	0.405	2.25	-1.0	0.503	0.835	0.00451	NA	0.612	0.259	0.698	0.612	0.0	0.507	0.764	0.0131	NA
Hs 578T	Buparlisib	3		sigmoid	sigmoid	Hs578T buparlisib 3	8	2.890	0.778	-0.425	0.233	1.71	-1.0	1.4	0.998	1.34e-08	NA	0.622	0.0272	0.779	0.622	0.0	1.57	0.991	8.01e-07	NA
BT-20	Pictilisib	2	72	sigmoid	sigmoid	BT20 pictilisib 0 2 72	8	1.746	0.308	-0.0521	0.379	2.35	-1.0	0.54	0.791	0.00908	NA	0.634	0.272	0.712	0.634	0.0	0.6	0.716	0.0229	NA
HCC70	Dactolisib	3	72	sigmoid	sigmoid	HCC70 dactolisib 0 3 72	8	2.430	0.738	0.321	0.312	18.6	-0.818	0.3	0.975	1.64e-05	NA	0.688	0.365	0.675	0.635	0.0134	0.338	0.97	2.7e-05	NA
Hs 578T	Alpelisib	3		sigmoid	sigmoid	Hs578T alpelisib 3	8	2.856	Inf	0.712	0.0759	0.872	0.616	0.828	0.963	5.21e-05	NA	Inf	0.641	0.901	0.65	0.553	0.853	0.955	8.85e-05	NA
BT-20	Buparlisib	1	72	sigmoid	sigmoid	BT20 buparlisib 0 1 72	8	2.131	0.598	-0.394	0.285	1.19	-0.763	1.35	0.992	4.68e-07	NA	0.663	0.0784	0.766	0.663	0.0	1.49	0.981	7.06e-06	NA
HCC1806	Buparlisib	1	72	sigmoid	sigmoid	HCC1806 buparlisib 0 1 72	8	2.742	0.748	-0.369	0.226	0.931	-0.415	2.75	1.0	2.95e-11	NA	0.69	0.0423	0.803	0.674	0.033	2.99	0.999	1.17e-09	NA
HCC1806	Buparlisib	2	72	sigmoid	sigmoid	HCC1806 buparlisib 0 2 72	8	2.827	0.759	-0.346	0.221	0.937	-0.392	2.75	1.0	2.72e-11	NA	0.69	0.0423	0.803	0.674	0.033	2.99	0.999	1.17e-09	NA
HCC1806	Buparlisib	3	72	sigmoid	sigmoid	HCC1806 buparlisib 0 3 72	8	3.195	0.808	-0.257	0.203	0.96	-0.303	2.74	1.0	2.03e-11	NA	0.69	0.0423	0.803	0.674	0.033	2.99	0.999	1.17e-09	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)