Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC38 Trametinib 2 72
sigmoid
sigmoid
HCC38 trametinib 0 2 72
 8 2.133
0.219
0.267
0.389
0.222
-0.00324
0.424
0.987
2.39e-06
NA
0.391
0.377
0.644
0.127
0.183
0.404
0.988
1.91e-06
NA
BT-549 GDC-0980 3 72
sigmoid
sigmoid
BT549 apitolisib 0 3 72
 8 1.802
0.162
0.0283
0.377
0.158
0.0179
1.2
0.994
2.53e-07
NA
0.268
0.302
0.709
0.128
0.294
1.2
0.992
4.85e-07
NA
BT-549 GDC-0980 1 72
sigmoid
sigmoid
BT549 apitolisib 0 1 72
 8 1.781
0.19
0.113
0.333
0.16
0.1
1.27
0.999
4.05e-10
NA
0.328
0.352
0.744
0.132
0.347
1.31
0.999
7.05e-10
NA
HCC70 AZD-6482 2 72
sigmoid
sigmoid
HCC70 AZD6482 0 2 72
 8 1.772
0.267
0.256
0.366
0.237
0.0255
0.43
0.987
2.27e-06
NA
1.16
0.438
0.706
0.133
0.306
0.437
0.986
3.03e-06
NA
BT-549 PI103 3 72
sigmoid
sigmoid
BT549 PI-103 0 3 72
 8 1.758
0.16
0.00249
0.391
0.166
-0.0225
1.12
0.989
1.19e-06
NA
0.279
0.297
0.704
0.134
0.28
1.12
0.985
3.23e-06
NA
Hs 578T MK2206 3
sigmoid
sigmoid
Hs578T MK-2206 3
 8 2.883
Inf
0.737
0.0965
0.144
0.768
1.94
0.962
5.58e-05
NA
Inf
0.666
0.873
0.135
0.7
1.85
0.967
3.69e-05
NA
BT-549 GDC-0980 2 72
sigmoid
sigmoid
BT549 apitolisib 0 2 72
 8 1.939
0.189
0.0264
0.357
0.193
-0.011
1.04
0.997
2.98e-08
NA
0.278
0.274
0.71
0.142
0.257
1.07
0.997
3.64e-08
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
Hs 578T PI103 2
sigmoid
sigmoid
Hs578T PI-103 2
 8 2.503
0.223
-0.0213
0.356
0.303
-0.15
0.858
0.999
7.33e-10
NA
0.206
0.167
0.661
0.152
0.121
0.921
0.999
1.9e-09
NA
BT-549 PI103 1 72
sigmoid
sigmoid
BT549 PI-103 0 1 72
 8 1.795
0.206
0.0898
0.34
0.185
0.0628
1.25
0.997
2.96e-08
NA
0.348
0.336
0.737
0.155
0.318
1.25
0.996
8.76e-08
NA
HCC38 Trametinib 1 72
sigmoid
sigmoid
HCC38 trametinib 0 1 72
 8 1.733
0.162
0.196
0.407
0.173
-0.0184
0.559
0.948
0.000139
NA
0.568
0.41
0.686
0.161
0.234
0.501
0.947
0.000151
NA
HCC38 GDC-0980 2 72
sigmoid
sigmoid
HCC38 apitolisib 0 2 72
 8 2.159
0.33
0.153
0.279
0.253
0.117
1.0
0.992
4.91e-07
NA
0.385
0.304
0.749
0.165
0.308
1.13
0.994
2.09e-07
NA
BT-549 PI103 2 72
sigmoid
sigmoid
BT549 PI-103 0 2 72
 8 1.893
0.218
0.0201
0.344
0.229
-0.0262
1.08
0.997
2.55e-08
NA
0.326
0.28
0.725
0.169
0.261
1.13
0.996
6.2e-08
NA
HCC38 Trametinib 3 72
sigmoid
sigmoid
HCC38 trametinib 0 3 72
 8 1.486
0.229
0.132
0.342
0.19
0.108
1.3
0.969
2.85e-05
NA
0.689
0.429
0.766
0.176
0.409
1.25
0.962
5.31e-05
NA
HCC70 ZSTK474 1 72
sigmoid
sigmoid
HCC70 ZSTK474 0 1 72
 8 1.332
0.167
-0.265
0.366
0.201
-0.206
1.85
0.975
1.56e-05
NA
0.289
0.264
0.782
0.182
0.299
1.96
0.971
2.35e-05
NA
HCC70 AZD-6482 3 72
sigmoid
sigmoid
HCC70 AZD6482 0 3 72
 8 2.532
1.43
0.435
0.247
0.421
0.226
0.492
0.983
4.63e-06
NA
1.13
0.431
0.729
0.208
0.286
0.5
0.982
6.2e-06
NA
HCC70 ZSTK474 2 72
sigmoid
sigmoid
HCC70 ZSTK474 0 2 72
 8 1.737
0.248
-0.0397
0.324
0.27
-0.0591
1.33
0.992
5.33e-07
NA
0.379
0.28
0.76
0.214
0.28
1.43
0.989
1.22e-06
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
HCC70 AS605240 1 72
sigmoid
sigmoid
HCC70 AS-605240 0 1 72
 8 1.387
10.4
0.487
0.159
0.247
0.497
1.34
0.963
5.14e-05
NA
Inf
0.663
0.894
0.23
0.672
1.39
0.961
6.01e-05
NA
Hs 578T Pictilisib 2
sigmoid
sigmoid
Hs578T pictilisib 2
 8 2.512
1.93
0.45
0.194
0.4
0.333
0.696
0.98
8e-06
NA
1.58
0.446
0.787
0.231
0.381
0.746
0.974
1.74e-05
NA
BT-20 PI103 2 72
sigmoid
sigmoid
BT20 PI-103 0 2 72
 8 1.725
0.235
-0.21
0.388
0.289
-0.212
1.7
0.975
1.64e-05
NA
0.319
0.202
0.721
0.239
0.205
1.81
0.961
5.88e-05
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA