Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC38	Omipalisib	3	72	sigmoid	sigmoid	HCC38 omipalisib 0 3 72	8	1.446	0.0145	-0.503	0.802	0.0539	-0.597	0.6	0.993	3.08e-07	NA	0.0449	0.134	0.499	0.0308	0.107	0.644	0.993	2.98e-07	NA
BT-20	AZD8055	3	72	sigmoid	sigmoid	BT20 AZD8055 0 3 72	8	2.694	0.0351	0.345	0.472	0.0116	0.313	0.89	0.934	0.000286	NA	0.0291	0.343	0.506	0.00813	0.306	0.743	0.922	0.000471	NA
HCC70	Torin2	2	72	sigmoid	sigmoid	HCC70 Torin2 0 2 72	8	1.826	0.0342	-0.522	0.671	0.401	-1.0	0.446	0.979	9.23e-06	NA	0.0639	0.0733	0.507	0.0639	0.0	0.462	0.969	2.98e-05	NA
HCC70	Torin2	3	72	sigmoid	sigmoid	HCC70 Torin2 0 3 72	8	2.425	0.076	-0.384	0.567	0.532	-0.933	0.541	0.988	1.88e-06	NA	0.0694	0.0576	0.51	0.0694	0.0	0.61	0.973	2.02e-05	NA
HCC38	Torin1	2	72	sigmoid	sigmoid	HCC38 Torin1 0 2 72	8	2.136	0.0241	0.0393	0.573	0.0203	0.0651	0.82	0.995	1.24e-07	NA	0.0309	0.247	0.512	0.013	0.267	0.88	0.996	4.87e-08	NA
HCC38	Omipalisib	1	72	sigmoid	sigmoid	HCC38 omipalisib 0 1 72	8	1.760	0.0231	-0.316	0.672	0.152	-0.638	0.438	0.97	2.61e-05	NA	0.0585	0.151	0.512	0.0499	0.0356	0.465	0.956	8.65e-05	NA
BT-549	Torin1	3	72	sigmoid	sigmoid	BT549 Torin1 0 3 72	8	1.757	0.0123	0.026	0.659	0.0112	0.0466	1.02	0.997	3.77e-08	NA	0.0235	0.309	0.513	0.00878	0.322	1.05	0.997	1.65e-08	NA
BT-20	Sirolimus	2	72	flat	flat	BT20 rapamycin 0 2 72	8	1.952	Inf	0.421	0.579	0.0	0.421	0.01	NA	NA	0.421	Inf	0.513	0.513	0.0	0.513	0.01	NA	NA	0.513
Hs 578T	WYE-125132	2		sigmoid	sigmoid	Hs578T WYE-132 2	8	2.544	0.0374	0.152	0.505	0.0268	0.147	1.04	0.999	8.81e-10	NA	0.0344	0.246	0.516	0.0183	0.239	1.03	0.999	2.53e-09	NA
BT-549	Torin1	2	72	sigmoid	sigmoid	BT549 Torin1 0 2 72	8	1.881	0.0165	0.0298	0.618	0.0147	0.0572	1.03	0.993	4.2e-07	NA	0.0262	0.287	0.52	0.0111	0.306	1.1	0.99	9.68e-07	NA
Hs 578T	AZD8055	3		sigmoid	sigmoid	Hs578T AZD8055 3	8	2.886	0.0538	0.232	0.451	0.0311	0.22	1.06	0.995	1.13e-07	NA	0.039	0.247	0.521	0.0208	0.231	0.989	0.995	1.55e-07	NA
Hs 578T	WYE-125132	3		sigmoid	sigmoid	Hs578T WYE-132 3	8	2.876	0.0568	0.189	0.452	0.0346	0.192	0.975	0.996	7.69e-08	NA	0.0403	0.224	0.522	0.0221	0.221	0.97	0.993	4.12e-07	NA
Hs 578T	Torin1	1		sigmoid	sigmoid	Hs578T Torin1 1	8	1.956	0.0217	0.0183	0.598	0.0203	0.0286	0.911	0.994	1.81e-07	NA	0.0321	0.267	0.524	0.0141	0.28	0.995	0.996	8.78e-08	NA
BT-20	WYE-125132	3	72	sigmoid	sigmoid	BT20 WYE-132 0 3 72	8	2.654	0.0504	0.282	0.465	0.0254	0.236	0.929	0.922	0.000468	NA	0.048	0.307	0.526	0.0182	0.246	0.698	0.918	0.000553	NA
BT-549	Torin1	1	72	sigmoid	sigmoid	BT549 Torin1 0 1 72	8	1.794	0.017	0.0603	0.621	0.0151	0.056	0.976	0.998	7.25e-09	NA	0.0333	0.32	0.532	0.0118	0.316	0.966	0.998	9.27e-09	NA
BT-20	Everolimus	3	72	flat	flat	BT20 everolimus 0 3 72	8	2.422	Inf	0.475	0.456	0.0	0.475	0.01	0.602	0.0632	0.543	Inf	0.478	0.534	0.0	0.478	0.01	0.561	0.0844	0.534
BT-20	Torin1	1	72	sigmoid	sigmoid	BT20 Torin1 0 1 72	8	2.022	0.0383	-0.105	0.566	0.0658	-0.179	0.565	0.991	7.45e-07	NA	0.0591	0.197	0.536	0.0286	0.182	0.624	0.994	2.54e-07	NA
HCC70	Torin2	1	72	sigmoid	sigmoid	HCC70 Torin2 0 1 72	8	1.364	0.0288	-0.732	0.772	0.183	-1.0	0.594	0.991	6.58e-07	NA	0.088	0.0644	0.539	0.088	0.0	0.622	0.988	1.95e-06	NA
HCC1806	Omipalisib	2	72	sigmoid	sigmoid	HCC1806 omipalisib 0 2 72	8	2.849	0.112	-0.311	0.479	0.543	-0.739	0.573	0.98	8.07e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
HCC1806	Omipalisib	3	72	sigmoid	sigmoid	HCC1806 omipalisib 0 3 72	8	3.217	0.147	-0.221	0.437	0.71	-0.707	0.559	0.981	7.41e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
HCC1806	Omipalisib	1	72	sigmoid	sigmoid	HCC1806 omipalisib 0 1 72	8	2.764	0.104	-0.333	0.49	0.508	-0.746	0.577	0.98	8.23e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
BT-20	Everolimus	2	72	flat	flat	BT20 everolimus 0 2 72	8	1.785	Inf	0.426	0.574	0.0	0.426	0.01	NA	NA	0.426	Inf	0.547	0.547	0.0	0.547	0.01	NA	NA	0.547
Hs 578T	WYE-125132	1		sigmoid	sigmoid	Hs578T WYE-132 1	8	2.015	0.0322	0.0601	0.551	0.0286	0.0544	0.962	0.998	4.17e-09	NA	0.0469	0.278	0.55	0.0207	0.275	0.978	0.999	2.33e-09	NA
BT-549	AZD8055	3	72	sigmoid	sigmoid	BT549 AZD8055 0 3 72	8	1.757	0.0178	0.159	0.59	0.0122	0.145	0.913	0.942	0.000193	NA	0.0479	0.383	0.555	0.00973	0.372	0.854	0.954	9.74e-05	NA
Hs 578T	AZD8055	2		sigmoid	sigmoid	Hs578T AZD8055 2	8	2.480	0.0521	0.149	0.469	0.0387	0.142	1.13	0.999	3.49e-10	NA	0.0495	0.253	0.557	0.0273	0.249	1.16	0.999	4.45e-10	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)