Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC1806	XL147	1	72	flat	flat	HCC1806 pilaralisib 0 1 72	8	2.732	Inf	1.02	0.00101	0.0	1.02	0.01	-4.53e-06	1.0	1.0	Inf	1.03	0.999	0.0	1.03	0.01	-0.000107	1.0	1.0
BT-549	XL147	1	72	flat	flat	BT549 pilaralisib 0 1 72	8	1.855	Inf	0.941	0.0385	0.0	0.941	0.01	-0.0931	1.0	0.954	Inf	0.946	0.965	0.0	0.946	0.01	-0.0808	1.0	0.958
HCC1806	XL147	3	72	flat	flat	HCC1806 pilaralisib 0 3 72	8	3.185	Inf	1.02	0.000871	0.0	1.02	0.01	-2.12e-06	1.0	1.0	Inf	1.03	0.999	0.0	1.03	0.01	-0.000107	1.0	1.0
HCC38	XL147	3	72	sigmoid	sigmoid	HCC38 pilaralisib 0 3 72	8	1.420	Inf	0.909	0.0219	0.114	0.921	5.0	0.815	0.00631	NA	Inf	0.936	0.985	0.114	0.945	5.0	0.813	0.00654	NA
HCC70	XL147	3	72	flat	flat	HCC70 pilaralisib 0 3 72	8	2.478	Inf	1.03	-0.0199	0.0	1.03	0.01	-0.318	1.0	1.02	Inf	1.03	1.03	0.0	1.03	0.01	-0.331	1.0	1.02
Hs 578T	XL147	3		flat	flat	Hs578T pilaralisib 3	8	2.879	Inf	0.971	-0.00618	0.0	0.971	0.01	0.331	0.299	1.0	Inf	0.959	1.01	0.0	0.959	0.01	0.319	0.315	1.0
BT-549	XL147	3	72	flat	flat	BT549 pilaralisib 0 3 72	8	1.772	Inf	0.933	0.0351	0.0	0.933	0.01	-0.0699	1.0	0.962	Inf	0.941	0.969	0.0	0.941	0.01	-0.0712	1.0	0.967
Hs 578T	XL147	1		flat	flat	Hs578T pilaralisib 1	8	2.013	Inf	0.967	0.00411	0.0	0.967	0.01	0.193	0.525	0.991	Inf	0.967	0.996	0.0	0.967	0.01	0.196	0.519	0.991
BT-549	XL147	2	72	flat	flat	BT549 pilaralisib 0 2 72	8	1.952	Inf	0.967	-0.00824	0.0	0.967	0.01	-0.000427	1.0	1.0	Inf	0.968	1.01	0.0	0.968	0.01	-0.000878	1.0	1.0
HCC70	XL147	2	72	flat	flat	HCC70 pilaralisib 0 2 72	8	1.789	Inf	0.966	0.0311	0.0	0.966	0.01	-0.12	1.0	0.965	Inf	0.97	0.973	0.0	0.97	0.01	-0.121	1.0	0.969
Hs 578T	XL147	2		flat	flat	Hs578T pilaralisib 2	8	2.509	Inf	0.976	0.000255	0.0	0.976	0.01	0.435	0.181	0.997	Inf	0.97	1.0	0.0	0.97	0.01	0.432	0.183	0.996
BT-549	WYE-125132	1	72	sigmoid	sigmoid	BT549 WYE-132 0 1 72	8	1.787	0.0317	0.11	0.542	0.026	0.0962	1.09	0.996	5.11e-08	NA	0.062	0.349	0.589	0.0213	0.338	1.05	0.997	3.82e-08	NA
BT-20	WYE-125132	1	72	sigmoid	sigmoid	BT20 WYE-132 0 1 72	8	2.067	0.0893	0.289	0.402	0.0435	0.256	1.0	0.987	2.28e-06	NA	0.154	0.403	0.647	0.0353	0.375	0.941	0.985	3.56e-06	NA
BT-549	WYE-125132	2	72	sigmoid	sigmoid	BT549 WYE-132 0 2 72	8	1.780	0.0329	0.0784	0.528	0.0287	0.0811	1.29	0.988	1.59e-06	NA	0.0545	0.333	0.604	0.0236	0.337	1.34	0.986	2.87e-06	NA
HCC38	WYE-125132	2	72	sigmoid	sigmoid	HCC38 WYE-132 0 2 72	8	2.143	0.0568	0.149	0.473	0.0413	0.124	0.896	0.998	9.66e-09	NA	0.078	0.305	0.587	0.0297	0.285	0.875	0.997	1.58e-08	NA
Hs 578T	WYE-125132	2		sigmoid	sigmoid	Hs578T WYE-132 2	8	2.544	0.0374	0.152	0.505	0.0268	0.147	1.04	0.999	8.81e-10	NA	0.0344	0.246	0.516	0.0183	0.239	1.03	0.999	2.53e-09	NA
Hs 578T	WYE-125132	1		sigmoid	sigmoid	Hs578T WYE-132 1	8	2.015	0.0322	0.0601	0.551	0.0286	0.0544	0.962	0.998	4.17e-09	NA	0.0469	0.278	0.55	0.0207	0.275	0.978	0.999	2.33e-09	NA
HCC1806	WYE-125132	1	72	sigmoid	sigmoid	HCC1806 WYE-132 0 1 72	8	2.790	0.603	0.466	0.292	0.0448	0.45	0.883	0.997	3.72e-08	NA	0.226	0.42	0.663	0.0335	0.402	0.855	0.996	8.79e-08	NA
Hs 578T	WYE-125132	3		sigmoid	sigmoid	Hs578T WYE-132 3	8	2.876	0.0568	0.189	0.452	0.0346	0.192	0.975	0.996	7.69e-08	NA	0.0403	0.224	0.522	0.0221	0.221	0.97	0.993	4.12e-07	NA
HCC70	WYE-125132	3	72	sigmoid	sigmoid	HCC70 WYE-132 0 3 72	8	2.417	Inf	0.592	0.246	0.0209	0.606	1.64	0.995	1.48e-07	NA	Inf	0.576	0.739	0.019	0.588	1.64	0.996	7.52e-08	NA
HCC1806	WYE-125132	3	72	sigmoid	sigmoid	HCC1806 WYE-132 0 3 72	8	3.242	Inf	0.531	0.255	0.0458	0.517	0.885	0.997	3.48e-08	NA	0.226	0.42	0.663	0.0335	0.402	0.855	0.996	8.79e-08	NA
BT-549	WYE-125132	3	72	sigmoid	sigmoid	BT549 WYE-132 0 3 72	8	1.662	0.0271	0.0265	0.567	0.0245	0.0525	1.1	0.992	5.72e-07	NA	0.0574	0.33	0.592	0.0203	0.345	1.13	0.991	6.54e-07	NA
HCC38	WYE-125132	3	72	sigmoid	sigmoid	HCC38 WYE-132 0 3 72	8	1.449	0.0494	-0.0216	0.518	0.0504	-0.0117	1.18	0.998	9.69e-09	NA	0.128	0.355	0.662	0.0441	0.361	1.2	0.998	9.53e-09	NA
BT-20	WYE-125132	2	72	sigmoid	sigmoid	BT20 WYE-132 0 2 72	8	2.053	0.012	0.142	0.633	0.00936	0.072	0.621	0.909	0.000752	NA	0.0232	0.316	0.475	0.00613	0.255	0.536	0.894	0.00119	NA
HCC70	WYE-125132	1	72	sigmoid	sigmoid	HCC70 WYE-132 0 1 72	8	1.382	0.0518	0.346	0.418	0.0175	0.348	1.1	0.985	3.58e-06	NA	Inf	0.579	0.727	0.0165	0.579	1.09	0.983	4.63e-06	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)