Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T KIN001-244 2
sigmoid
sigmoid
Hs578T KIN001-244 2
 8 2.505
Inf
0.819
0.0357
4.8
0.531
1.14
0.891
0.0013
NA
44.3
0.788
0.957
4.79
0.457
1.1
0.878
0.0018
NA
Hs 578T KIN001-244 3
sigmoid
sigmoid
Hs578T KIN001-244 3
 8 2.888
Inf
0.866
0.00909
5.05
0.617
1.35
0.858
0.00289
NA
50.0
0.818
0.988
5.2
0.474
1.31
0.842
0.00391
NA
BT-20 GDC-0980 3 72
sigmoid
sigmoid
BT20 apitolisib 0 3 72
 8 2.502
0.0976
-0.115
0.437
0.107
-0.0716
1.53
0.994
2.41e-07
NA
0.0894
0.13
0.62
0.0732
0.163
1.96
0.996
6.83e-08
NA
Hs 578T GDC-0980 3
sigmoid
sigmoid
Hs578T apitolisib 3
 8 2.831
0.243
0.145
0.315
0.19
0.112
1.02
0.998
4.02e-09
NA
0.179
0.206
0.665
0.114
0.196
1.09
0.999
9.76e-10
NA
Hs 578T GDC-0980 2
sigmoid
sigmoid
Hs578T apitolisib 2
 8 2.520
0.176
-0.0558
0.391
0.275
-0.201
0.758
0.997
3.91e-08
NA
0.159
0.151
0.627
0.121
0.1
0.818
0.998
1.45e-08
NA
Hs 578T GDC-0980 1
sigmoid
sigmoid
Hs578T apitolisib 1
 8 1.984
0.119
-0.0587
0.419
0.141
-0.0865
0.957
0.997
3.35e-08
NA
0.161
0.224
0.662
0.0914
0.223
1.04
0.997
2.87e-08
NA
HCC1806 GDC-0980 1 72
sigmoid
sigmoid
HCC1806 apitolisib 0 1 72
 8 2.696
1.24
0.339
0.152
0.739
0.223
1.15
0.995
1.52e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
HCC38 GDC-0980 3 72
sigmoid
sigmoid
HCC38 apitolisib 0 3 72
 8 1.437
0.371
-0.0189
0.29
0.513
-0.179
0.946
0.993
3.35e-07
NA
0.96
0.359
0.808
0.393
0.295
0.998
0.993
3.51e-07
NA
HCC38 GDC-0980 2 72
sigmoid
sigmoid
HCC38 apitolisib 0 2 72
 8 2.159
0.33
0.153
0.279
0.253
0.117
1.0
0.992
4.91e-07
NA
0.385
0.304
0.749
0.165
0.308
1.13
0.994
2.09e-07
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
HCC1806 GDC-0980 2 72
sigmoid
sigmoid
HCC1806 apitolisib 0 2 72
 8 2.781
1.32
0.355
0.148
0.746
0.241
1.15
0.995
1.49e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
BT-549 GDC-0980 3 72
sigmoid
sigmoid
BT549 apitolisib 0 3 72
 8 1.802
0.162
0.0283
0.377
0.158
0.0179
1.2
0.994
2.53e-07
NA
0.268
0.302
0.709
0.128
0.294
1.2
0.992
4.85e-07
NA
BT-549 GDC-0980 2 72
sigmoid
sigmoid
BT549 apitolisib 0 2 72
 8 1.939
0.189
0.0264
0.357
0.193
-0.011
1.04
0.997
2.98e-08
NA
0.278
0.274
0.71
0.142
0.257
1.07
0.997
3.64e-08
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
BT-549 GDC-0980 1 72
sigmoid
sigmoid
BT549 apitolisib 0 1 72
 8 1.781
0.19
0.113
0.333
0.16
0.1
1.27
0.999
4.05e-10
NA
0.328
0.352
0.744
0.132
0.347
1.31
0.999
7.05e-10
NA
HCC1806 GDC-0980 3 72
sigmoid
sigmoid
HCC1806 apitolisib 0 3 72
 8 3.149
1.8
0.418
0.132
0.77
0.31
1.14
0.995
1.41e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
BT-20 GDC-0980 1 72
sigmoid
sigmoid
BT20 apitolisib 0 1 72
 8 2.001
0.0935
-0.289
0.498
0.128
-0.251
1.29
0.994
2.71e-07
NA
0.113
0.126
0.62
0.0885
0.151
1.48
0.996
7.34e-08
NA
BT-20 GDC-0980 2 72
sigmoid
sigmoid
BT20 apitolisib 0 2 72
 8 1.659
0.0456
-0.414
0.639
0.0629
-0.33
1.58
0.993
4.18e-07
NA
0.0641
0.131
0.575
0.0506
0.168
1.74
0.995
1.2e-07
NA
BT-549 Everolimus 2 72
flat
flat
BT549 everolimus 0 2 72
 8 1.909
Inf
0.566
0.407
0.0
0.566
0.01
-0.646
1.0
0.594
Inf
0.627
0.648
0.0
0.627
0.01
-1.01
1.0
0.649
HCC1806 Everolimus 3 72
sigmoid
sigmoid
HCC1806 everolimus 0 3 72
 8 3.239
Inf
0.813
0.159
0.000271
0.812
0.356
0.879
0.00175
NA
Inf
0.727
0.765
0.00022
0.729
0.377
0.879
0.00177
NA
HCC1806 Everolimus 2 72
sigmoid
sigmoid
HCC1806 everolimus 0 2 72
 8 2.871
Inf
0.79
0.178
0.000277
0.79
0.365
0.879
0.00176
NA
Inf
0.727
0.765
0.000222
0.728
0.374
0.879
0.00178
NA
HCC70 Everolimus 1 72
flat
flat
HCC70 everolimus 0 1 72
 8 1.366
Inf
0.569
0.354
0.0
0.569
0.01
0.623
0.0534
0.643
Inf
0.718
0.766
0.0
0.718
0.01
0.62
0.0547
0.765
HCC70 Everolimus 2 72
flat
flat
HCC70 everolimus 0 2 72
 8 1.730
Inf
0.674
0.227
0.0
0.674
0.01
0.271
0.388
0.766
Inf
0.735
0.812
0.0
0.735
0.01
0.264
0.399
0.807