Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-20 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | BT20 AZD6482 0 3 72 | 8 | 2.601 | 1.68 | 0.3 | 0.173 | 8.38 | -1.0 | 0.685 | 0.959 | 6.72e-05 | NA | 1.5 | 0.326 | 0.805 | 1.5 | 0.0 | 0.733 | 0.925 | 0.000414 | NA |
BT-549 | Pictilisib | 3 | 72 | sigmoid | sigmoid | BT549 pictilisib 0 3 72 | 8 | 1.767 | 1.42 | 0.276 | 0.169 | 4.62 | -0.67 | 0.722 | 0.998 | 9.61e-09 | NA | 2.47 | 0.452 | 0.863 | 2.47 | 0.0 | 0.742 | 0.997 | 2.13e-08 | NA |
BT-20 | TGX221 | 3 | 72 | flat | flat | BT20 TGX-221 0 3 72 | 8 | 2.469 | Inf | 1.01 | 0.0147 | 0.0 | 1.01 | 0.01 | -0.0563 | 1.0 | 0.982 | Inf | 1.01 | 0.983 | 0.0 | 1.01 | 0.01 | -0.0552 | 1.0 | 0.979 |
BT-20 | Everolimus | 3 | 72 | flat | flat | BT20 everolimus 0 3 72 | 8 | 2.422 | Inf | 0.475 | 0.456 | 0.0 | 0.475 | 0.01 | 0.602 | 0.0632 | 0.543 | Inf | 0.478 | 0.534 | 0.0 | 0.478 | 0.01 | 0.561 | 0.0844 | 0.534 |
BT-20 | AS605240 | 3 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 3 72 | 8 | 2.607 | Inf | 0.845 | 0.0823 | 4.13 | 0.662 | 0.292 | 0.729 | 0.0199 | NA | Inf | 0.81 | 0.897 | 3.97 | 0.589 | 0.284 | 0.712 | 0.0239 | NA |
BT-20 | Torin1 | 3 | 72 | sigmoid | sigmoid | BT20 Torin1 0 3 72 | 8 | 2.569 | 0.0237 | 0.0343 | 0.572 | 0.0199 | 0.0736 | 0.899 | 0.993 | 2.77e-07 | NA | 0.0208 | 0.184 | 0.46 | 0.0119 | 0.204 | 0.944 | 0.997 | 2.51e-08 | NA |
HCC38 | TGX221 | 3 | 72 | sigmoid | sigmoid | HCC38 TGX-221 0 3 72 | 8 | 1.484 | 3688.0 | 0.815 | 0.0743 | 320.0 | 0.243 | 0.273 | 0.867 | 0.00233 | NA | 3261706.0 | 0.866 | 0.945 | 320.0 | 0.458 | 0.269 | 0.867 | 0.00238 | NA |
HCC38 | Torin1 | 3 | 72 | sigmoid | sigmoid | HCC38 Torin1 0 3 72 | 8 | 1.441 | 0.0231 | -0.202 | 0.666 | 0.0412 | -0.248 | 0.698 | 0.999 | 5.79e-10 | NA | 0.0787 | 0.266 | 0.572 | 0.0306 | 0.245 | 0.714 | 0.999 | 5.55e-10 | NA |
BT-20 | Torin2 | 3 | 72 | sigmoid | sigmoid | BT20 Torin2 0 3 72 | 8 | 2.458 | 0.019 | -0.64 | 0.751 | 0.234 | -1.0 | 0.438 | 0.959 | 6.92e-05 | NA | 0.0147 | 0.0148 | 0.379 | 0.0123 | 0.0598 | 0.727 | 0.977 | 1.28e-05 | NA |
BT-20 | Pictilisib | 3 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 3 72 | 8 | 2.566 | 0.839 | 0.172 | 0.22 | 0.914 | -0.0483 | 1.09 | 0.954 | 9.59e-05 | NA | 0.843 | 0.254 | 0.768 | 0.809 | 0.0179 | 0.898 | 0.918 | 0.000551 | NA |
BT-20 | Buparlisib | 3 | 72 | sigmoid | sigmoid | BT20 buparlisib 0 3 72 | 8 | 2.529 | 0.629 | -0.303 | 0.26 | 1.06 | -0.565 | 1.46 | 0.994 | 2.13e-07 | NA | 0.603 | 0.0696 | 0.764 | 0.603 | 0.0 | 1.52 | 0.984 | 4.36e-06 | NA |
BT-20 | Trametinib | 3 | 72 | sigmoid | sigmoid | BT20 trametinib 0 3 72 | 8 | 2.539 | Inf | 0.64 | 0.208 | 0.104 | 0.541 | 0.392 | 0.967 | 3.69e-05 | NA | Inf | 0.604 | 0.761 | 0.0656 | 0.513 | 0.391 | 0.964 | 4.56e-05 | NA |
BT-549 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | BT549 AZD6482 0 3 72 | 8 | 1.744 | 8.87 | 0.616 | 0.0979 | 2.2 | 0.324 | 0.749 | 0.993 | 2.93e-07 | NA | 115.0 | 0.69 | 0.918 | 1.91 | 0.476 | 0.744 | 0.993 | 4.19e-07 | NA |
BT-549 | AZD8055 | 3 | 72 | sigmoid | sigmoid | BT549 AZD8055 0 3 72 | 8 | 1.757 | 0.0178 | 0.159 | 0.59 | 0.0122 | 0.145 | 0.913 | 0.942 | 0.000193 | NA | 0.0479 | 0.383 | 0.555 | 0.00973 | 0.372 | 0.854 | 0.954 | 9.74e-05 | NA |
BT-20 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | BT20 WYE-132 0 3 72 | 8 | 2.654 | 0.0504 | 0.282 | 0.465 | 0.0254 | 0.236 | 0.929 | 0.922 | 0.000468 | NA | 0.048 | 0.307 | 0.526 | 0.0182 | 0.246 | 0.698 | 0.918 | 0.000553 | NA |
BT-20 | GDC-0980 | 3 | 72 | sigmoid | sigmoid | BT20 apitolisib 0 3 72 | 8 | 2.502 | 0.0976 | -0.115 | 0.437 | 0.107 | -0.0716 | 1.53 | 0.994 | 2.41e-07 | NA | 0.0894 | 0.13 | 0.62 | 0.0732 | 0.163 | 1.96 | 0.996 | 6.83e-08 | NA |
BT-549 | MK2206 | 3 | 72 | sigmoid | sigmoid | BT549 MK-2206 0 3 72 | 8 | 1.685 | Inf | 0.714 | 0.131 | 0.123 | 0.711 | 3.44 | 0.953 | 0.000102 | NA | Inf | 0.771 | 0.895 | 0.123 | 0.768 | 3.25 | 0.949 | 0.000136 | NA |
BT-20 | XL147 | 3 | 72 | flat | flat | BT20 pilaralisib 0 3 72 | 8 | 2.647 | Inf | 0.755 | 0.102 | 0.0 | 0.755 | 0.01 | 0.0679 | 0.81 | 0.885 | Inf | 0.708 | 0.871 | 0.0 | 0.708 | 0.01 | 0.0505 | 0.856 | 0.857 |
BT-549 | PIK-93 | 3 | 72 | sigmoid | sigmoid | BT549 PIK-93 0 3 72 | 8 | 1.807 | 20.1 | 0.719 | 0.0848 | 231.0 | -1.0 | 0.45 | 0.716 | 0.0229 | NA | 67.9 | 0.761 | 0.925 | 67.9 | 0.0 | 0.431 | 0.686 | 0.0309 | NA |
BT-549 | Sirolimus | 3 | 72 | flat | flat | BT549 rapamycin 0 3 72 | 8 | 1.703 | Inf | 0.455 | 0.482 | 0.0 | 0.455 | 0.01 | 0.376 | 0.243 | 0.518 | Inf | 0.582 | 0.626 | 0.0 | 0.582 | 0.01 | 0.436 | 0.179 | 0.625 |
BT-20 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | BT20 ZSTK474 0 3 72 | 8 | 2.609 | 0.457 | -0.00222 | 0.296 | 0.783 | -0.31 | 0.895 | 0.982 | 5.76e-06 | NA | 0.422 | 0.163 | 0.702 | 0.422 | 0.0 | 0.82 | 0.971 | 2.52e-05 | NA |
BT-20 | Omipalisib | 3 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 3 72 | 8 | 2.586 | 0.00689 | -0.587 | 0.893 | 0.044 | -0.714 | 0.478 | 0.958 | 7.32e-05 | NA | 0.00572 | 0.017 | 0.281 | 0.00491 | 0.0669 | 0.945 | 0.983 | 4.7e-06 | NA |
BT-20 | BX-912 | 3 | 72 | flat | flat | BT20 BX-912 0 3 72 | 8 | 2.619 | Inf | 0.904 | 0.0795 | 0.0 | 0.904 | 0.01 | 0.000173 | 0.999 | 0.918 | Inf | 0.879 | 0.9 | 0.0 | 0.879 | 0.01 | 0.00619 | 0.982 | 0.896 |
HCC70 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 3 72 | 8 | 2.442 | Inf | 0.571 | 0.287 | 0.0133 | 0.574 | 1.17 | 0.98 | 8.55e-06 | NA | Inf | 0.554 | 0.694 | 0.0116 | 0.556 | 1.17 | 0.974 | 1.69e-05 | NA |
HCC70 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | HCC70 AZD6482 0 3 72 | 8 | 2.532 | 1.43 | 0.435 | 0.247 | 0.421 | 0.226 | 0.492 | 0.983 | 4.63e-06 | NA | 1.13 | 0.431 | 0.729 | 0.208 | 0.286 | 0.5 | 0.982 | 6.2e-06 | NA |