Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
Hs 578T	Omipalisib	2		sigmoid	sigmoid	Hs578T omipalisib 2	8	2.507	0.0155	-0.52	0.766	0.239	-1.0	0.402	0.993	3.45e-07	NA	0.0114	0.028	0.355	0.0114	0.0	0.468	0.981	6.9e-06	NA
BT-20	AS605240	2	72	sigmoid	sigmoid	BT20 AS-605240 0 2 72	8	1.846	4509270.0	0.729	0.203	320.0	0.31	0.101	0.845	0.00373	NA	4.4e+12	0.764	0.821	56.5	0.46	0.101	0.843	0.00388	NA
BT-20	CAL-101	2	72	flat	flat	BT20 idelalisib 0 2 72	8	1.768	Inf	0.818	0.0943	0.0	0.818	0.01	0.226	0.463	0.898	Inf	0.845	0.918	0.0	0.845	0.01	0.222	0.471	0.912
Hs 578T	KIN001-244	2		sigmoid	sigmoid	Hs578T KIN001-244 2	8	2.505	Inf	0.819	0.0357	4.8	0.531	1.14	0.891	0.0013	NA	44.3	0.788	0.957	4.79	0.457	1.1	0.878	0.0018	NA
HCC38	Torin1	2	72	sigmoid	sigmoid	HCC38 Torin1 0 2 72	8	2.136	0.0241	0.0393	0.573	0.0203	0.0651	0.82	0.995	1.24e-07	NA	0.0309	0.247	0.512	0.013	0.267	0.88	0.996	4.87e-08	NA
BT-549	Trametinib	2	72	sigmoid	sigmoid	BT549 trametinib 0 2 72	8	1.914	Inf	0.602	0.2	0.0685	0.581	0.837	0.995	1.05e-07	NA	Inf	0.654	0.822	0.0601	0.638	0.839	0.995	1.04e-07	NA
Hs 578T	MK2206	2		sigmoid	sigmoid	Hs578T MK-2206 2	8	2.530	Inf	0.664	0.131	0.0699	0.752	1.34	0.75	0.0156	NA	Inf	0.628	0.848	0.0616	0.717	1.21	0.767	0.0126	NA
HCC70	Pictilisib	2	72	sigmoid	sigmoid	HCC70 pictilisib 0 2 72	8	1.783	0.811	0.124	0.189	0.858	-0.0372	1.27	0.973	2.08e-05	NA	1.25	0.358	0.852	0.678	0.278	1.32	0.963	5.09e-05	NA
BT-20	XL147	2	72	flat	flat	BT20 pilaralisib 0 2 72	8	1.784	Inf	0.759	0.073	0.0	0.759	0.01	-0.0058	1.0	0.907	Inf	0.796	0.937	0.0	0.796	0.01	-0.00637	1.0	0.92
Hs 578T	PI103	2		sigmoid	sigmoid	Hs578T PI-103 2	8	2.503	0.223	-0.0213	0.356	0.303	-0.15	0.858	0.999	7.33e-10	NA	0.206	0.167	0.661	0.152	0.121	0.921	0.999	1.9e-09	NA
HCC38	Torin2	2	72	sigmoid	sigmoid	HCC38 Torin2 0 2 72	8	2.140	0.0146	-0.48	0.793	0.0654	-0.634	0.545	0.993	3.78e-07	NA	0.0176	0.056	0.391	0.015	0.0502	0.68	0.989	1.33e-06	NA
HCC70	XL147	2	72	flat	flat	HCC70 pilaralisib 0 2 72	8	1.789	Inf	0.966	0.0311	0.0	0.966	0.01	-0.12	1.0	0.965	Inf	0.97	0.973	0.0	0.97	0.01	-0.121	1.0	0.969
Hs 578T	PIK-93	2		sigmoid	sigmoid	Hs578T PIK-93 2	8	2.467	2.43	0.415	0.0931	3.62	-0.243	0.991	0.991	8.05e-07	NA	2.34	0.426	0.901	1.93	0.0909	1.04	0.987	2.24e-06	NA
BT-549	Dactolisib	2	72	sigmoid	sigmoid	BT549 dactolisib 0 2 72	8	1.889	0.00968	-0.00862	0.677	0.00884	0.0542	1.27	0.985	3.3e-06	NA	0.0134	0.266	0.48	0.00701	0.305	1.45	0.988	1.53e-06	NA
BT-549	WYE-125132	2	72	sigmoid	sigmoid	BT549 WYE-132 0 2 72	8	1.780	0.0329	0.0784	0.528	0.0287	0.0811	1.29	0.988	1.59e-06	NA	0.0545	0.333	0.604	0.0236	0.337	1.34	0.986	2.87e-06	NA
Hs 578T	Sirolimus	2		flat	flat	Hs578T rapamycin 2	8	2.536	Inf	0.623	0.341	0.0	0.623	0.01	0.16	0.593	0.66	Inf	0.589	0.623	0.0	0.589	0.01	-0.232	1.0	0.624
HCC38	Trametinib	2	72	sigmoid	sigmoid	HCC38 trametinib 0 2 72	8	2.133	0.219	0.267	0.389	0.222	-0.00324	0.424	0.987	2.39e-06	NA	0.391	0.377	0.644	0.127	0.183	0.404	0.988	1.91e-06	NA
HCC70	GDC-0980	2	72	sigmoid	sigmoid	HCC70 apitolisib 0 2 72	8	1.676	0.318	-0.0849	0.284	0.451	-0.205	0.983	0.976	1.34e-05	NA	0.536	0.27	0.795	0.285	0.252	1.11	0.972	2.28e-05	NA
Hs 578T	TGX221	2		sigmoid	sigmoid	Hs578T TGX-221 2	8	2.462	Inf	0.816	0.0307	0.904	0.781	1.29	0.964	4.56e-05	NA	Inf	0.789	0.964	0.834	0.754	1.3	0.96	6.63e-05	NA
HCC70	TGX221	2	72	sigmoid	sigmoid	HCC70 TGX-221 0 2 72	8	1.786	1.77	0.467	0.233	0.531	0.227	0.503	0.948	0.000139	NA	5.85	0.575	0.806	3.44	0.0897	0.372	0.937	0.000249	NA
BT-20	PIK-93	2	72	sigmoid	sigmoid	BT20 PIK-93 0 2 72	8	1.798	0.792	0.155	0.286	14.1	-1.0	0.382	0.81	0.00687	NA	2.8	0.373	0.764	2.8	0.0	0.344	0.77	0.0121	NA
Hs 578T	Torin1	2		sigmoid	sigmoid	Hs578T Torin1 2	8	2.548	0.0205	0.144	0.566	0.0148	0.14	1.0	0.999	3.13e-10	NA	0.0182	0.241	0.463	0.00975	0.24	1.04	0.999	6.11e-10	NA
HCC38	WYE-125132	2	72	sigmoid	sigmoid	HCC38 WYE-132 0 2 72	8	2.143	0.0568	0.149	0.473	0.0413	0.124	0.896	0.998	9.66e-09	NA	0.078	0.305	0.587	0.0297	0.285	0.875	0.997	1.58e-08	NA
BT-549	XL147	2	72	flat	flat	BT549 pilaralisib 0 2 72	8	1.952	Inf	0.967	-0.00824	0.0	0.967	0.01	-0.000427	1.0	1.0	Inf	0.968	1.01	0.0	0.968	0.01	-0.000878	1.0	1.0
Hs 578T	Torin2	2		sigmoid	sigmoid	Hs578T Torin2 2	8	2.528	0.0153	-0.467	0.778	0.112	-0.771	0.47	0.986	2.55e-06	NA	0.0122	0.0353	0.352	0.0109	0.036	0.668	0.984	4.09e-06	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)