Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
Hs 578T	TGX221	2		sigmoid	sigmoid	Hs578T TGX-221 2	8	2.462	Inf	0.816	0.0307	0.904	0.781	1.29	0.964	4.56e-05	NA	Inf	0.789	0.964	0.834	0.754	1.3	0.96	6.63e-05	NA
HCC38	Omipalisib	2	72	sigmoid	sigmoid	HCC38 omipalisib 0 2 72	8	2.124	0.0404	-0.47	0.634	0.45	-1.0	0.456	0.979	9.71e-06	NA	0.0507	0.0595	0.494	0.0507	0.0	0.556	0.96	6.44e-05	NA
HCC70	CAL-101	2	72	sigmoid	sigmoid	HCC70 idelalisib 0 2 72	8	1.738	Inf	0.62	0.0432	0.959	0.611	3.13	0.965	4.31e-05	NA	Inf	0.693	0.965	0.935	0.686	3.13	0.96	6.52e-05	NA
HCC70	Trametinib	3	72	sigmoid	sigmoid	HCC70 trametinib 0 3 72	8	2.463	Inf	0.56	0.361	0.00419	0.548	0.954	0.95	0.000123	NA	Inf	0.542	0.618	0.00342	0.533	0.965	0.958	7.33e-05	NA
BT-20	Trametinib	2	72	sigmoid	sigmoid	BT20 trametinib 0 2 72	8	1.723	0.761	0.303	0.289	11.1	-0.768	0.347	0.965	4.13e-05	NA	2.56	0.478	0.77	2.56	0.0	0.362	0.957	8.16e-05	NA
HCC70	CAL-101	3	72	sigmoid	sigmoid	HCC70 idelalisib 0 3 72	8	2.510	Inf	0.724	0.0241	1.39	0.69	2.52	0.964	4.57e-05	NA	Inf	0.689	0.973	1.33	0.655	2.52	0.956	8.64e-05	NA
HCC70	BX-912	2	72	sigmoid	sigmoid	HCC70 BX-912 0 2 72	8	1.693	1.25	0.00257	0.0619	1.25	-0.00649	5.0	0.971	2.55e-05	NA	1.44	0.311	0.961	1.2	0.306	5.0	0.956	8.35e-05	NA
HCC38	Omipalisib	1	72	sigmoid	sigmoid	HCC38 omipalisib 0 1 72	8	1.760	0.0231	-0.316	0.672	0.152	-0.638	0.438	0.97	2.61e-05	NA	0.0585	0.151	0.512	0.0499	0.0356	0.465	0.956	8.65e-05	NA
Hs 578T	Alpelisib	3		sigmoid	sigmoid	Hs578T alpelisib 3	8	2.856	Inf	0.712	0.0759	0.872	0.616	0.828	0.963	5.21e-05	NA	Inf	0.641	0.901	0.65	0.553	0.853	0.955	8.85e-05	NA
HCC70	Dactolisib	2	72	sigmoid	sigmoid	HCC70 dactolisib 0 2 72	8	1.677	0.312	0.238	0.341	0.195	0.103	0.493	0.954	9.66e-05	NA	2.24	0.447	0.738	0.0858	0.419	0.56	0.954	9.8e-05	NA
BT-549	AZD8055	3	72	sigmoid	sigmoid	BT549 AZD8055 0 3 72	8	1.757	0.0178	0.159	0.59	0.0122	0.145	0.913	0.942	0.000193	NA	0.0479	0.383	0.555	0.00973	0.372	0.854	0.954	9.74e-05	NA
Hs 578T	TGX221	3		sigmoid	sigmoid	Hs578T TGX-221 3	8	2.818	24.2	0.885	0.0148	88.9	-1.0	0.843	0.958	7.66e-05	NA	23.4	0.846	0.98	23.4	0.0	0.862	0.953	0.000103	NA
BT-549	Omipalisib	2	72	sigmoid	sigmoid	BT549 omipalisib 0 2 72	8	1.990	0.0104	-0.291	0.751	0.026	-0.32	0.542	0.966	4.09e-05	NA	0.0175	0.127	0.422	0.011	0.118	0.58	0.953	0.000102	NA
HCC38	MK2206	1	72	sigmoid	sigmoid	HCC38 MK-2206 0 1 72	8	1.789	19.4	0.698	0.0995	320.0	-0.949	0.38	0.956	8.33e-05	NA	61.8	0.746	0.914	61.8	0.0	0.386	0.951	0.000115	NA
HCC70	PI103	1	72	sigmoid	sigmoid	HCC70 PI-103 0 1 72	8	1.305	1.04	-0.0102	0.104	1.14	-0.107	2.26	0.957	7.9e-05	NA	1.83	0.399	0.938	1.08	0.349	2.28	0.949	0.000133	NA
BT-549	MK2206	3	72	sigmoid	sigmoid	BT549 MK-2206 0 3 72	8	1.685	Inf	0.714	0.131	0.123	0.711	3.44	0.953	0.000102	NA	Inf	0.771	0.895	0.123	0.768	3.25	0.949	0.000136	NA
BT-549	PIK-93	2	72	sigmoid	sigmoid	BT549 PIK-93 0 2 72	8	1.983	7.03	0.687	0.0641	29.9	-1.0	0.759	0.956	8.81e-05	NA	10.4	0.713	0.939	10.4	0.0	0.788	0.949	0.000136	NA
BT-20	Buparlisib	2	72	sigmoid	sigmoid	BT20 buparlisib 0 2 72	8	1.743	0.334	-0.45	0.391	0.844	-0.82	1.05	0.972	2.21e-05	NA	0.487	0.105	0.718	0.487	0.0	1.12	0.948	0.000142	NA
HCC70	Trametinib	2	72	sigmoid	sigmoid	HCC70 trametinib 0 2 72	8	1.721	0.506	0.504	0.395	0.00469	0.467	0.581	0.944	0.000179	NA	Inf	0.612	0.687	0.00389	0.585	0.57	0.948	0.000138	NA
BT-20	MK2206	2	72	sigmoid	sigmoid	BT20 MK-2206 0 2 72	8	1.739	0.823	0.0896	0.246	4.34	-1.0	0.661	0.965	4.36e-05	NA	1.47	0.348	0.806	1.47	0.0	0.715	0.947	0.000145	NA
HCC38	Trametinib	1	72	sigmoid	sigmoid	HCC38 trametinib 0 1 72	8	1.733	0.162	0.196	0.407	0.173	-0.0184	0.559	0.948	0.000139	NA	0.568	0.41	0.686	0.161	0.234	0.501	0.947	0.000151	NA
BT-549	AZD-6482	2	72	sigmoid	sigmoid	BT549 AZD6482 0 2 72	8	1.973	9.15	0.635	0.112	120.0	-1.0	0.426	0.951	0.000115	NA	19.4	0.672	0.895	19.4	0.0	0.437	0.946	0.000154	NA
BT-20	Alpelisib	1	72	sigmoid	sigmoid	BT20 alpelisib 0 1 72	8	2.077	1.14	0.046	0.196	3.52	-1.0	0.977	0.966	4.1e-05	NA	1.32	0.26	0.825	1.32	0.0	1.13	0.942	0.000194	NA
Hs 578T	CAL-101	1		sigmoid	sigmoid	Hs578T idelalisib 1	8	2.050	27.9	0.72	0.0764	4.56	0.356	0.688	0.945	0.000168	NA	18.7	0.734	0.925	18.7	0.0	0.568	0.941	0.000203	NA
Hs 578T	Alpelisib	1		sigmoid	sigmoid	Hs578T alpelisib 1	8	2.097	2.3	0.449	0.205	42.0	-1.0	0.378	0.954	9.56e-05	NA	3.9	0.508	0.803	3.9	0.0	0.401	0.94	0.000216	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)