Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC70 | CAL-101 | 2 | 72 | sigmoid | sigmoid | HCC70 idelalisib 0 2 72 | 8 | 1.738 | Inf | 0.62 | 0.0432 | 0.959 | 0.611 | 3.13 | 0.965 | 4.31e-05 | NA | Inf | 0.693 | 0.965 | 0.935 | 0.686 | 3.13 | 0.96 | 6.52e-05 | NA |
BT-20 | Trametinib | 2 | 72 | sigmoid | sigmoid | BT20 trametinib 0 2 72 | 8 | 1.723 | 0.761 | 0.303 | 0.289 | 11.1 | -0.768 | 0.347 | 0.965 | 4.13e-05 | NA | 2.56 | 0.478 | 0.77 | 2.56 | 0.0 | 0.362 | 0.957 | 8.16e-05 | NA |
BT-20 | MK2206 | 2 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 2 72 | 8 | 1.739 | 0.823 | 0.0896 | 0.246 | 4.34 | -1.0 | 0.661 | 0.965 | 4.36e-05 | NA | 1.47 | 0.348 | 0.806 | 1.47 | 0.0 | 0.715 | 0.947 | 0.000145 | NA |
HCC70 | CAL-101 | 3 | 72 | sigmoid | sigmoid | HCC70 idelalisib 0 3 72 | 8 | 2.510 | Inf | 0.724 | 0.0241 | 1.39 | 0.69 | 2.52 | 0.964 | 4.57e-05 | NA | Inf | 0.689 | 0.973 | 1.33 | 0.655 | 2.52 | 0.956 | 8.64e-05 | NA |
Hs 578T | TGX221 | 2 | sigmoid | sigmoid | Hs578T TGX-221 2 | 8 | 2.462 | Inf | 0.816 | 0.0307 | 0.904 | 0.781 | 1.29 | 0.964 | 4.56e-05 | NA | Inf | 0.789 | 0.964 | 0.834 | 0.754 | 1.3 | 0.96 | 6.63e-05 | NA | |
HCC70 | AS605240 | 1 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 1 72 | 8 | 1.387 | 10.4 | 0.487 | 0.159 | 0.247 | 0.497 | 1.34 | 0.963 | 5.14e-05 | NA | Inf | 0.663 | 0.894 | 0.23 | 0.672 | 1.39 | 0.961 | 6.01e-05 | NA |
HCC70 | Dactolisib | 1 | 72 | sigmoid | sigmoid | HCC70 dactolisib 0 1 72 | 8 | 1.400 | 0.0808 | -0.0667 | 0.501 | 3.34 | -1.0 | 0.295 | 0.963 | 5.02e-05 | NA | 0.753 | 0.344 | 0.673 | 0.753 | 0.0 | 0.308 | 0.962 | 5.37e-05 | NA |
Hs 578T | Alpelisib | 3 | sigmoid | sigmoid | Hs578T alpelisib 3 | 8 | 2.856 | Inf | 0.712 | 0.0759 | 0.872 | 0.616 | 0.828 | 0.963 | 5.21e-05 | NA | Inf | 0.641 | 0.901 | 0.65 | 0.553 | 0.853 | 0.955 | 8.85e-05 | NA | |
Hs 578T | MK2206 | 3 | sigmoid | sigmoid | Hs578T MK-2206 3 | 8 | 2.883 | Inf | 0.737 | 0.0965 | 0.144 | 0.768 | 1.94 | 0.962 | 5.58e-05 | NA | Inf | 0.666 | 0.873 | 0.135 | 0.7 | 1.85 | 0.967 | 3.69e-05 | NA | |
Hs 578T | Dactolisib | 3 | sigmoid | sigmoid | Hs578T dactolisib 3 | 8 | 2.837 | 0.0118 | 0.0569 | 0.624 | 0.00848 | 0.115 | 0.799 | 0.96 | 6.53e-05 | NA | 0.00728 | 0.164 | 0.377 | 0.0043 | 0.212 | 1.05 | 0.968 | 3.34e-05 | NA | |
BT-20 | Torin2 | 3 | 72 | sigmoid | sigmoid | BT20 Torin2 0 3 72 | 8 | 2.458 | 0.019 | -0.64 | 0.751 | 0.234 | -1.0 | 0.438 | 0.959 | 6.92e-05 | NA | 0.0147 | 0.0148 | 0.379 | 0.0123 | 0.0598 | 0.727 | 0.977 | 1.28e-05 | NA |
BT-549 | Trametinib | 1 | 72 | sigmoid | sigmoid | BT549 trametinib 0 1 72 | 8 | 1.812 | Inf | 0.596 | 0.202 | 0.131 | 0.523 | 0.61 | 0.959 | 6.65e-05 | NA | 28.3 | 0.664 | 0.828 | 3.47 | 0.254 | 0.337 | 0.933 | 0.000305 | NA |
BT-20 | AZD-6482 | 3 | 72 | sigmoid | sigmoid | BT20 AZD6482 0 3 72 | 8 | 2.601 | 1.68 | 0.3 | 0.173 | 8.38 | -1.0 | 0.685 | 0.959 | 6.72e-05 | NA | 1.5 | 0.326 | 0.805 | 1.5 | 0.0 | 0.733 | 0.925 | 0.000414 | NA |
Hs 578T | TGX221 | 3 | sigmoid | sigmoid | Hs578T TGX-221 3 | 8 | 2.818 | 24.2 | 0.885 | 0.0148 | 88.9 | -1.0 | 0.843 | 0.958 | 7.66e-05 | NA | 23.4 | 0.846 | 0.98 | 23.4 | 0.0 | 0.862 | 0.953 | 0.000103 | NA | |
BT-20 | Omipalisib | 3 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 3 72 | 8 | 2.586 | 0.00689 | -0.587 | 0.893 | 0.044 | -0.714 | 0.478 | 0.958 | 7.32e-05 | NA | 0.00572 | 0.017 | 0.281 | 0.00491 | 0.0669 | 0.945 | 0.983 | 4.7e-06 | NA |
HCC70 | PI103 | 1 | 72 | sigmoid | sigmoid | HCC70 PI-103 0 1 72 | 8 | 1.305 | 1.04 | -0.0102 | 0.104 | 1.14 | -0.107 | 2.26 | 0.957 | 7.9e-05 | NA | 1.83 | 0.399 | 0.938 | 1.08 | 0.349 | 2.28 | 0.949 | 0.000133 | NA |
BT-20 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | BT20 ZSTK474 0 1 72 | 8 | 1.940 | 0.788 | 0.0217 | 0.122 | 0.819 | -0.0395 | 1.99 | 0.957 | 7.76e-05 | NA | 0.942 | 0.272 | 0.913 | 0.677 | 0.249 | 2.09 | 0.934 | 0.000293 | NA |
BT-549 | PIK-93 | 2 | 72 | sigmoid | sigmoid | BT549 PIK-93 0 2 72 | 8 | 1.983 | 7.03 | 0.687 | 0.0641 | 29.9 | -1.0 | 0.759 | 0.956 | 8.81e-05 | NA | 10.4 | 0.713 | 0.939 | 10.4 | 0.0 | 0.788 | 0.949 | 0.000136 | NA |
HCC38 | MK2206 | 1 | 72 | sigmoid | sigmoid | HCC38 MK-2206 0 1 72 | 8 | 1.789 | 19.4 | 0.698 | 0.0995 | 320.0 | -0.949 | 0.38 | 0.956 | 8.33e-05 | NA | 61.8 | 0.746 | 0.914 | 61.8 | 0.0 | 0.386 | 0.951 | 0.000115 | NA |
BT-20 | Pictilisib | 3 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 3 72 | 8 | 2.566 | 0.839 | 0.172 | 0.22 | 0.914 | -0.0483 | 1.09 | 0.954 | 9.59e-05 | NA | 0.843 | 0.254 | 0.768 | 0.809 | 0.0179 | 0.898 | 0.918 | 0.000551 | NA |
HCC70 | Dactolisib | 2 | 72 | sigmoid | sigmoid | HCC70 dactolisib 0 2 72 | 8 | 1.677 | 0.312 | 0.238 | 0.341 | 0.195 | 0.103 | 0.493 | 0.954 | 9.66e-05 | NA | 2.24 | 0.447 | 0.738 | 0.0858 | 0.419 | 0.56 | 0.954 | 9.8e-05 | NA |
Hs 578T | Alpelisib | 1 | sigmoid | sigmoid | Hs578T alpelisib 1 | 8 | 2.097 | 2.3 | 0.449 | 0.205 | 42.0 | -1.0 | 0.378 | 0.954 | 9.56e-05 | NA | 3.9 | 0.508 | 0.803 | 3.9 | 0.0 | 0.401 | 0.94 | 0.000216 | NA | |
BT-549 | MK2206 | 3 | 72 | sigmoid | sigmoid | BT549 MK-2206 0 3 72 | 8 | 1.685 | Inf | 0.714 | 0.131 | 0.123 | 0.711 | 3.44 | 0.953 | 0.000102 | NA | Inf | 0.771 | 0.895 | 0.123 | 0.768 | 3.25 | 0.949 | 0.000136 | NA |
BT-549 | AZD-6482 | 2 | 72 | sigmoid | sigmoid | BT549 AZD6482 0 2 72 | 8 | 1.973 | 9.15 | 0.635 | 0.112 | 120.0 | -1.0 | 0.426 | 0.951 | 0.000115 | NA | 19.4 | 0.672 | 0.895 | 19.4 | 0.0 | 0.437 | 0.946 | 0.000154 | NA |
HCC70 | Trametinib | 3 | 72 | sigmoid | sigmoid | HCC70 trametinib 0 3 72 | 8 | 2.463 | Inf | 0.56 | 0.361 | 0.00419 | 0.548 | 0.954 | 0.95 | 0.000123 | NA | Inf | 0.542 | 0.618 | 0.00342 | 0.533 | 0.965 | 0.958 | 7.33e-05 | NA |