Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 Trametinib 2 72
sigmoid
sigmoid
HCC70 trametinib 0 2 72
 8 1.721
0.506
0.504
0.395
0.00469
0.467
0.581
0.944
0.000179
NA
Inf
0.612
0.687
0.00389
0.585
0.57
0.948
0.000138
NA
BT-549 PIK-93 2 72
sigmoid
sigmoid
BT549 PIK-93 0 2 72
 8 1.983
7.03
0.687
0.0641
29.9
-1.0
0.759
0.956
8.81e-05
NA
10.4
0.713
0.939
10.4
0.0
0.788
0.949
0.000136
NA
BT-549 MK2206 3 72
sigmoid
sigmoid
BT549 MK-2206 0 3 72
 8 1.685
Inf
0.714
0.131
0.123
0.711
3.44
0.953
0.000102
NA
Inf
0.771
0.895
0.123
0.768
3.25
0.949
0.000136
NA
HCC70 PI103 1 72
sigmoid
sigmoid
HCC70 PI-103 0 1 72
 8 1.305
1.04
-0.0102
0.104
1.14
-0.107
2.26
0.957
7.9e-05
NA
1.83
0.399
0.938
1.08
0.349
2.28
0.949
0.000133
NA
HCC38 MK2206 1 72
sigmoid
sigmoid
HCC38 MK-2206 0 1 72
 8 1.789
19.4
0.698
0.0995
320.0
-0.949
0.38
0.956
8.33e-05
NA
61.8
0.746
0.914
61.8
0.0
0.386
0.951
0.000115
NA
Hs 578T TGX221 3
sigmoid
sigmoid
Hs578T TGX-221 3
 8 2.818
24.2
0.885
0.0148
88.9
-1.0
0.843
0.958
7.66e-05
NA
23.4
0.846
0.98
23.4
0.0
0.862
0.953
0.000103
NA
BT-549 Omipalisib 2 72
sigmoid
sigmoid
BT549 omipalisib 0 2 72
 8 1.990
0.0104
-0.291
0.751
0.026
-0.32
0.542
0.966
4.09e-05
NA
0.0175
0.127
0.422
0.011
0.118
0.58
0.953
0.000102
NA