Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 Omipalisib 1 72
sigmoid
sigmoid
HCC1806 omipalisib 0 1 72
 8 2.764
0.104
-0.333
0.49
0.508
-0.746
0.577
0.98
8.23e-06
NA
0.0642
0.0481
0.54
0.0538
0.0749
0.919
0.979
9.93e-06
NA
Hs 578T Omipalisib 1
sigmoid
sigmoid
Hs578T omipalisib 1
 8 2.079
0.00552
-0.546
0.842
0.17
-1.0
0.321
0.98
8.1e-06
NA
0.0079
0.0459
0.351
0.0079
0.0
0.369
0.984
4.12e-06
NA
HCC38 Torin2 3 72
sigmoid
sigmoid
HCC38 Torin2 0 3 72
 8 1.385
0.013
-0.624
0.855
0.0547
-0.706
0.615
0.996
8.13e-08
NA
0.0407
0.0986
0.484
0.0311
0.0829
0.669
0.997
3.31e-08
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
HCC1806 Omipalisib 2 72
sigmoid
sigmoid
HCC1806 omipalisib 0 2 72
 8 2.849
0.112
-0.311
0.479
0.543
-0.739
0.573
0.98
8.07e-06
NA
0.0642
0.0481
0.54
0.0538
0.0749
0.919
0.979
9.93e-06
NA
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA
HCC70 PI103 1 72
sigmoid
sigmoid
HCC70 PI-103 0 1 72
 8 1.305
1.04
-0.0102
0.104
1.14
-0.107
2.26
0.957
7.9e-05
NA
1.83
0.399
0.938
1.08
0.349
2.28
0.949
0.000133
NA
Hs 578T AS605240 1
sigmoid
sigmoid
Hs578T AS-605240 1
 8 2.015
0.758
0.341
0.212
0.333
0.265
0.921
0.991
7.83e-07
NA
1.42
0.447
0.811
0.246
0.408
0.964
0.989
1.51e-06
NA
BT-20 ZSTK474 1 72
sigmoid
sigmoid
BT20 ZSTK474 0 1 72
 8 1.940
0.788
0.0217
0.122
0.819
-0.0395
1.99
0.957
7.76e-05
NA
0.942
0.272
0.913
0.677
0.249
2.09
0.934
0.000293
NA
HCC70 Buparlisib 1 72
sigmoid
sigmoid
HCC70 buparlisib 0 1 72
 8 1.374
0.608
-0.494
0.231
1.27
-0.9
1.4
0.98
7.6e-06
NA
0.988
0.151
0.861
0.98
0.00578
1.46
0.973
1.91e-05
NA
Hs 578T WYE-125132 3
sigmoid
sigmoid
Hs578T WYE-132 3
 8 2.876
0.0568
0.189
0.452
0.0346
0.192
0.975
0.996
7.69e-08
NA
0.0403
0.224
0.522
0.0221
0.221
0.97
0.993
4.12e-07
NA
Hs 578T TGX221 3
sigmoid
sigmoid
Hs578T TGX-221 3
 8 2.818
24.2
0.885
0.0148
88.9
-1.0
0.843
0.958
7.66e-05
NA
23.4
0.846
0.98
23.4
0.0
0.862
0.953
0.000103
NA
HCC70 Pictilisib 1 72
sigmoid
sigmoid
HCC70 pictilisib 0 1 72
 8 1.409
0.408
-0.099
0.284
0.578
-0.245
1.14
0.996
7.62e-08
NA
0.888
0.325
0.816
0.477
0.261
1.19
0.995
1.2e-07
NA
HCC38 Dactolisib 2 72
sigmoid
sigmoid
HCC38 dactolisib 0 2 72
 8 2.120
0.0118
-0.0557
0.668
0.0118
-0.00134
0.785
0.98
7.61e-06
NA
0.0145
0.204
0.447
0.00701
0.245
0.927
0.988
1.88e-06
NA
BT-20 Torin1 1 72
sigmoid
sigmoid
BT20 Torin1 0 1 72
 8 2.022
0.0383
-0.105
0.566
0.0658
-0.179
0.565
0.991
7.45e-07
NA
0.0591
0.197
0.536
0.0286
0.182
0.624
0.994
2.54e-07
NA
HCC1806 Omipalisib 3 72
sigmoid
sigmoid
HCC1806 omipalisib 0 3 72
 8 3.217
0.147
-0.221
0.437
0.71
-0.707
0.559
0.981
7.41e-06
NA
0.0642
0.0481
0.54
0.0538
0.0749
0.919
0.979
9.93e-06
NA
HCC70 AZD8055 2 72
sigmoid
sigmoid
HCC70 AZD8055 0 2 72
 8 1.724
0.17
0.404
0.346
0.0331
0.385
0.897
0.996
7.36e-08
NA
Inf
0.543
0.728
0.0284
0.531
0.905
0.996
6.22e-08
NA
Hs 578T PI103 2
sigmoid
sigmoid
Hs578T PI-103 2
 8 2.503
0.223
-0.0213
0.356
0.303
-0.15
0.858
0.999
7.33e-10
NA
0.206
0.167
0.661
0.152
0.121
0.921
0.999
1.9e-09
NA
BT-20 Omipalisib 3 72
sigmoid
sigmoid
BT20 omipalisib 0 3 72
 8 2.586
0.00689
-0.587
0.893
0.044
-0.714
0.478
0.958
7.32e-05
NA
0.00572
0.017
0.281
0.00491
0.0669
0.945
0.983
4.7e-06
NA
BT-549 Torin1 1 72
sigmoid
sigmoid
BT549 Torin1 0 1 72
 8 1.794
0.017
0.0603
0.621
0.0151
0.056
0.976
0.998
7.25e-09
NA
0.0333
0.32
0.532
0.0118
0.316
0.966
0.998
9.27e-09
NA
HCC70 AS605240 2 72
sigmoid
sigmoid
HCC70 AS-605240 0 2 72
 8 1.771
6.13
0.558
0.126
1.21
0.339
0.698
0.981
7.24e-06
NA
785.0
0.643
0.894
0.946
0.496
0.708
0.978
1.04e-05
NA
HCC38 ZSTK474 1 72
sigmoid
sigmoid
HCC38 ZSTK474 0 1 72
 8 1.742
2.47
0.456
0.132
1.34
0.202
0.843
0.991
7.12e-07
NA
9.02
0.575
0.893
1.0
0.426
0.869
0.99
1.01e-06
NA
BT-549 ZSTK474 3 72
sigmoid
sigmoid
BT549 ZSTK474 0 3 72
 8 1.776
0.504
0.139
0.267
0.616
-0.0912
0.836
0.996
7.06e-08
NA
0.994
0.368
0.789
0.489
0.218
0.808
0.995
9.19e-08
NA
HCC1806 MK2206 1 72
sigmoid
sigmoid
HCC1806 MK-2206 0 1 72
 8 2.746
47.7
0.818
0.0504
320.0
-0.715
0.466
0.981
7.02e-06
NA
Inf
0.769
0.934
4.46
0.507
0.566
0.976
1.46e-05
NA