Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC38	PIK-93	3	72	sigmoid	sigmoid	HCC38 PIK-93 0 3 72	8	1.382	5.05	0.598	0.061	2.34	0.358	1.63	0.919	0.000533	NA	Inf	0.734	0.959	2.23	0.586	1.64	0.914	0.000645	NA
Hs 578T	BX-912	1		sigmoid	sigmoid	Hs578T BX-912 1	8	2.001	0.771	-0.202	0.191	1.16	-0.444	1.57	0.997	2.97e-08	NA	0.901	0.159	0.851	0.822	0.0702	1.64	0.994	1.9e-07	NA
HCC70	PI103	3	72	sigmoid	sigmoid	HCC70 PI-103 0 3 72	8	2.446	1.51	0.227	0.0983	1.57	-0.0288	1.54	0.986	2.66e-06	NA	1.48	0.303	0.906	1.15	0.168	1.59	0.976	1.42e-05	NA
Hs 578T	Buparlisib	3		sigmoid	sigmoid	Hs578T buparlisib 3	8	2.890	0.778	-0.425	0.233	1.71	-1.0	1.4	0.998	1.34e-08	NA	0.622	0.0272	0.779	0.622	0.0	1.57	0.991	8.01e-07	NA
HCC70	Buparlisib	3	72	sigmoid	sigmoid	HCC70 buparlisib 0 3 72	8	2.439	0.968	-0.156	0.167	1.7	-0.624	1.43	0.995	1.16e-07	NA	0.944	0.122	0.852	0.944	0.0	1.57	0.988	1.57e-06	NA
HCC70	MK2206	2	72	sigmoid	sigmoid	HCC70 MK-2206 0 2 72	8	1.690	0.446	0.244	0.2	0.301	0.226	1.53	0.973	1.92e-05	NA	1.03	0.448	0.851	0.266	0.44	1.56	0.965	4.11e-05	NA
BT-20	PI103	3	72	sigmoid	sigmoid	BT20 PI-103 0 3 72	8	2.496	0.373	0.0139	0.282	0.387	-0.0286	1.52	0.994	1.99e-07	NA	0.359	0.183	0.735	0.279	0.162	1.56	0.988	1.71e-06	NA
HCC70	ZSTK474	3	72	sigmoid	sigmoid	HCC70 ZSTK474 0 3 72	8	2.502	0.455	0.176	0.223	0.345	0.155	1.35	0.991	8.07e-07	NA	0.401	0.265	0.782	0.24	0.274	1.55	0.987	1.99e-06	NA
BT-20	ZSTK474	2	72	sigmoid	sigmoid	BT20 ZSTK474 0 2 72	8	1.787	0.286	-0.19	0.347	0.373	-0.234	1.46	0.992	4.53e-07	NA	0.391	0.199	0.743	0.29	0.184	1.55	0.988	1.84e-06	NA
BT-20	Buparlisib	3	72	sigmoid	sigmoid	BT20 buparlisib 0 3 72	8	2.529	0.629	-0.303	0.26	1.06	-0.565	1.46	0.994	2.13e-07	NA	0.603	0.0696	0.764	0.603	0.0	1.52	0.984	4.36e-06	NA
BT-20	Buparlisib	1	72	sigmoid	sigmoid	BT20 buparlisib 0 1 72	8	2.131	0.598	-0.394	0.285	1.19	-0.763	1.35	0.992	4.68e-07	NA	0.663	0.0784	0.766	0.663	0.0	1.49	0.981	7.06e-06	NA
HCC70	PIK-93	2	72	sigmoid	sigmoid	HCC70 PIK-93 0 2 72	8	1.705	4.34	0.647	0.0132	9.3	-1.0	1.44	0.888	0.0014	NA	6.01	0.718	0.991	6.01	0.0	1.49	0.872	0.00208	NA
BT-20	GDC-0980	1	72	sigmoid	sigmoid	BT20 apitolisib 0 1 72	8	2.001	0.0935	-0.289	0.498	0.128	-0.251	1.29	0.994	2.71e-07	NA	0.113	0.126	0.62	0.0885	0.151	1.48	0.996	7.34e-08	NA
HCC38	CAL-101	1	72	sigmoid	sigmoid	HCC38 idelalisib 0 1 72	8	1.723	Inf	0.92	0.00328	1.18	0.903	1.47	0.768	0.0125	NA	Inf	0.932	0.997	1.16	0.918	1.48	0.763	0.0133	NA
BT-549	PIK-93	1	72	sigmoid	sigmoid	BT549 PIK-93 0 1 72	8	1.777	Inf	0.691	0.0438	1.77	0.561	1.47	0.989	1.31e-06	NA	Inf	0.742	0.963	1.64	0.646	1.47	0.988	1.83e-06	NA
HCC70	Buparlisib	1	72	sigmoid	sigmoid	HCC70 buparlisib 0 1 72	8	1.374	0.608	-0.494	0.231	1.27	-0.9	1.4	0.98	7.6e-06	NA	0.988	0.151	0.861	0.98	0.00578	1.46	0.973	1.91e-05	NA
BT-549	Dactolisib	2	72	sigmoid	sigmoid	BT549 dactolisib 0 2 72	8	1.889	0.00968	-0.00862	0.677	0.00884	0.0542	1.27	0.985	3.3e-06	NA	0.0134	0.266	0.48	0.00701	0.305	1.45	0.988	1.53e-06	NA
HCC1806	PI103	3	72	sigmoid	sigmoid	HCC1806 PI-103 0 3 72	8	3.126	Inf	0.91	0.00588	1.72	0.873	1.43	0.782	0.0103	NA	Inf	0.866	0.992	1.61	0.817	1.44	0.762	0.0134	NA
HCC70	MK2206	3	72	sigmoid	sigmoid	HCC70 MK-2206 0 3 72	8	2.378	1.43	0.423	0.139	0.451	0.39	1.31	0.983	5.28e-06	NA	1.47	0.445	0.859	0.349	0.437	1.44	0.977	1.2e-05	NA
HCC1806	PI103	2	72	sigmoid	sigmoid	HCC1806 PI-103 0 2 72	8	2.758	Inf	0.898	0.00662	1.71	0.857	1.43	0.781	0.0105	NA	Inf	0.866	0.992	1.61	0.817	1.44	0.762	0.0134	NA
HCC1806	PI103	1	72	sigmoid	sigmoid	HCC1806 PI-103 0 1 72	8	2.673	Inf	0.895	0.00682	1.71	0.853	1.43	0.781	0.0106	NA	Inf	0.866	0.992	1.61	0.817	1.44	0.762	0.0134	NA
HCC38	PI103	2	72	sigmoid	sigmoid	HCC38 PI-103 0 2 72	8	2.094	0.856	0.226	0.167	0.672	0.135	1.3	0.986	2.7e-06	NA	1.04	0.359	0.851	0.488	0.33	1.43	0.981	6.52e-06	NA
HCC70	ZSTK474	2	72	sigmoid	sigmoid	HCC70 ZSTK474 0 2 72	8	1.737	0.248	-0.0397	0.324	0.27	-0.0591	1.33	0.992	5.33e-07	NA	0.379	0.28	0.76	0.214	0.28	1.43	0.989	1.22e-06	NA
Hs 578T	BX-912	2		sigmoid	sigmoid	Hs578T BX-912 2	8	2.540	1.07	-0.019	0.174	1.79	-0.489	1.33	0.998	6.37e-09	NA	1.01	0.164	0.828	1.01	0.0	1.4	0.996	7.64e-08	NA
HCC38	WYE-125132	1	72	sigmoid	sigmoid	HCC38 WYE-132 0 1 72	8	1.708	0.0604	0.142	0.447	0.0481	0.134	1.36	0.997	3.43e-08	NA	0.115	0.384	0.669	0.0413	0.381	1.4	0.996	6.46e-08	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)