Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 AS605240 2 72
sigmoid
sigmoid
HCC1806 AS-605240 0 2 72
 8 2.813
Inf
0.913
0.0124
0.569
0.913
2.8
0.936
0.000261
NA
Inf
0.883
0.983
0.559
0.882
2.81
0.931
0.000333
NA
HCC1806 AS605240 3 72
sigmoid
sigmoid
HCC1806 AS-605240 0 3 72
 8 3.181
Inf
0.923
0.011
0.57
0.923
2.81
0.936
0.000257
NA
Inf
0.883
0.983
0.559
0.882
2.81
0.931
0.000333
NA
HCC1806 AS605240 1 72
sigmoid
sigmoid
HCC1806 AS-605240 0 1 72
 8 2.728
Inf
0.911
0.0128
0.569
0.91
2.8
0.936
0.000262
NA
Inf
0.883
0.983
0.559
0.882
2.81
0.931
0.000333
NA
BT-20 PI103 1 72
sigmoid
sigmoid
BT20 PI-103 0 1 72
 8 1.924
0.646
-0.0114
0.16
0.659
-0.0268
2.6
0.978
1.1e-05
NA
0.753
0.258
0.883
0.579
0.252
2.68
0.964
4.79e-05
NA
HCC70 CAL-101 3 72
sigmoid
sigmoid
HCC70 idelalisib 0 3 72
 8 2.510
Inf
0.724
0.0241
1.39
0.69
2.52
0.964
4.57e-05
NA
Inf
0.689
0.973
1.33
0.655
2.52
0.956
8.64e-05
NA
Hs 578T BX-912 3
sigmoid
sigmoid
Hs578T BX-912 3
 8 2.805
1.04
0.0121
0.125
1.09
-0.0661
2.36
0.992
4.22e-07
NA
0.936
0.148
0.883
0.841
0.116
2.45
0.982
5.7e-06
NA
HCC70 PI103 1 72
sigmoid
sigmoid
HCC70 PI-103 0 1 72
 8 1.305
1.04
-0.0102
0.104
1.14
-0.107
2.26
0.957
7.9e-05
NA
1.83
0.399
0.938
1.08
0.349
2.28
0.949
0.000133
NA
BT-20 ZSTK474 1 72
sigmoid
sigmoid
BT20 ZSTK474 0 1 72
 8 1.940
0.788
0.0217
0.122
0.819
-0.0395
1.99
0.957
7.76e-05
NA
0.942
0.272
0.913
0.677
0.249
2.09
0.934
0.000293
NA
HCC38 MK2206 2 72
sigmoid
sigmoid
HCC38 MK-2206 0 2 72
 8 2.159
Inf
0.788
0.0476
0.776
0.775
1.99
0.972
2.1e-05
NA
Inf
0.785
0.951
0.752
0.772
1.98
0.969
2.9e-05
NA
HCC70 ZSTK474 1 72
sigmoid
sigmoid
HCC70 ZSTK474 0 1 72
 8 1.332
0.167
-0.265
0.366
0.201
-0.206
1.85
0.975
1.56e-05
NA
0.289
0.264
0.782
0.182
0.299
1.96
0.971
2.35e-05
NA
BT-20 GDC-0980 3 72
sigmoid
sigmoid
BT20 apitolisib 0 3 72
 8 2.502
0.0976
-0.115
0.437
0.107
-0.0716
1.53
0.994
2.41e-07
NA
0.0894
0.13
0.62
0.0732
0.163
1.96
0.996
6.83e-08
NA
Hs 578T CAL-101 3
sigmoid
sigmoid
Hs578T idelalisib 3
 8 2.874
Inf
0.854
0.0202
1.12
0.835
1.91
0.991
6.68e-07
NA
Inf
0.805
0.972
1.07
0.781
1.92
0.99
9.77e-07
NA
Hs 578T MK2206 1
sigmoid
sigmoid
Hs578T MK-2206 1
 8 2.039
Inf
0.608
0.165
0.087
0.665
2.09
0.9
0.00101
NA
Inf
0.641
0.845
0.0803
0.689
1.9
0.908
0.000775
NA
HCC38 PIK-93 2 72
sigmoid
sigmoid
HCC38 PIK-93 0 2 72
 8 2.107
31.9
0.661
0.0151
2.16
0.497
1.86
0.922
0.000468
NA
Inf
0.676
0.987
1.97
0.545
1.87
0.907
0.000813
NA
Hs 578T MK2206 3
sigmoid
sigmoid
Hs578T MK-2206 3
 8 2.883
Inf
0.737
0.0965
0.144
0.768
1.94
0.962
5.58e-05
NA
Inf
0.666
0.873
0.135
0.7
1.85
0.967
3.69e-05
NA
BT-20 PI103 2 72
sigmoid
sigmoid
BT20 PI-103 0 2 72
 8 1.725
0.235
-0.21
0.388
0.289
-0.212
1.7
0.975
1.64e-05
NA
0.319
0.202
0.721
0.239
0.205
1.81
0.961
5.88e-05
NA
HCC70 Pictilisib 3 72
sigmoid
sigmoid
HCC70 pictilisib 0 3 72
 8 2.450
1.32
0.305
0.102
0.938
0.225
1.76
0.983
4.73e-06
NA
1.28
0.351
0.901
0.766
0.303
1.81
0.973
2.06e-05
NA
HCC38 Buparlisib 2 72
sigmoid
sigmoid
HCC38 buparlisib 0 2 72
 8 2.142
0.876
-0.185
0.172
1.24
-0.413
1.74
0.996
5.03e-08
NA
0.959
0.146
0.861
0.893
0.0606
1.8
0.992
4.3e-07
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
BT-20 GDC-0980 2 72
sigmoid
sigmoid
BT20 apitolisib 0 2 72
 8 1.659
0.0456
-0.414
0.639
0.0629
-0.33
1.58
0.993
4.18e-07
NA
0.0641
0.131
0.575
0.0506
0.168
1.74
0.995
1.2e-07
NA
BT-549 KIN001-244 2 72
sigmoid
sigmoid
BT549 KIN001-244 0 2 72
 8 1.920
Inf
0.882
0.00561
2.72
0.793
1.67
0.73
0.0197
NA
Inf
0.89
0.995
2.6
0.813
1.68
0.718
0.0225
NA
HCC38 Buparlisib 1 72
sigmoid
sigmoid
HCC38 buparlisib 0 1 72
 8 1.738
0.912
-0.226
0.194
1.46
-0.57
1.62
0.999
9.48e-10
NA
1.2
0.192
0.858
1.12
0.0495
1.66
0.998
4.36e-09
NA
BT-549 Buparlisib 2 72
sigmoid
sigmoid
BT549 buparlisib 0 2 72
 8 1.913
0.681
-0.306
0.217
1.08
-0.538
1.59
0.998
1.31e-08
NA
0.821
0.132
0.838
0.769
0.0514
1.66
0.996
8.95e-08
NA
HCC70 CAL-101 1 72
sigmoid
sigmoid
HCC70 idelalisib 0 1 72
 8 1.384
2.78
0.485
0.0894
0.883
0.424
1.65
0.972
2.11e-05
NA
Inf
0.662
0.941
0.846
0.626
1.66
0.97
2.79e-05
NA
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA