Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 Pictilisib 1 72
sigmoid
sigmoid
HCC70 pictilisib 0 1 72
 8 1.409
0.408
-0.099
0.284
0.578
-0.245
1.14
0.996
7.62e-08
NA
0.888
0.325
0.816
0.477
0.261
1.19
0.995
1.2e-07
NA
HCC70 Pictilisib 2 72
sigmoid
sigmoid
HCC70 pictilisib 0 2 72
 8 1.783
0.811
0.124
0.189
0.858
-0.0372
1.27
0.973
2.08e-05
NA
1.25
0.358
0.852
0.678
0.278
1.32
0.963
5.09e-05
NA
HCC70 Pictilisib 3 72
sigmoid
sigmoid
HCC70 pictilisib 0 3 72
 8 2.450
1.32
0.305
0.102
0.938
0.225
1.76
0.983
4.73e-06
NA
1.28
0.351
0.901
0.766
0.303
1.81
0.973
2.06e-05
NA
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
HCC70 Omipalisib 1 72
sigmoid
sigmoid
HCC70 omipalisib 0 1 72
 8 1.358
0.00496
-0.785
1.14
0.0157
-0.775
0.812
0.989
1.34e-06
NA
0.0123
0.0486
0.349
0.011
0.0462
0.833
0.984
3.73e-06
NA
HCC70 Omipalisib 2 72
sigmoid
sigmoid
HCC70 omipalisib 0 2 72
 8 1.682
0.00746
-0.705
1.01
0.0241
-0.703
0.749
0.991
6.69e-07
NA
0.0135
0.0399
0.359
0.0121
0.0458
0.852
0.989
1.45e-06
NA
HCC70 Omipalisib 3 72
sigmoid
sigmoid
HCC70 omipalisib 0 3 72
 8 2.458
0.0158
-0.404
0.771
0.0319
-0.379
0.8
0.99
8.95e-07
NA
0.0148
0.051
0.376
0.0127
0.0733
1.02
0.996
4.59e-08
NA
HCC70 MK2206 1 72
sigmoid
sigmoid
HCC70 MK-2206 0 1 72
 8 1.444
0.314
-0.0266
0.337
0.618
-0.336
0.758
0.991
6.35e-07
NA
0.925
0.353
0.775
0.521
0.172
0.737
0.99
1.08e-06
NA
HCC70 MK2206 2 72
sigmoid
sigmoid
HCC70 MK-2206 0 2 72
 8 1.690
0.446
0.244
0.2
0.301
0.226
1.53
0.973
1.92e-05
NA
1.03
0.448
0.851
0.266
0.44
1.56
0.965
4.11e-05
NA
HCC70 MK2206 3 72
sigmoid
sigmoid
HCC70 MK-2206 0 3 72
 8 2.378
1.43
0.423
0.139
0.451
0.39
1.31
0.983
5.28e-06
NA
1.47
0.445
0.859
0.349
0.437
1.44
0.977
1.2e-05
NA
HCC70 PI103 1 72
sigmoid
sigmoid
HCC70 PI-103 0 1 72
 8 1.305
1.04
-0.0102
0.104
1.14
-0.107
2.26
0.957
7.9e-05
NA
1.83
0.399
0.938
1.08
0.349
2.28
0.949
0.000133
NA
HCC70 PI103 2 72
sigmoid
sigmoid
HCC70 PI-103 0 2 72
 8 1.739
1.19
0.0238
0.151
2.67
-0.766
1.15
0.997
2.59e-08
NA
1.68
0.312
0.885
1.68
0.0
1.21
0.996
6.86e-08
NA
HCC70 PI103 3 72
sigmoid
sigmoid
HCC70 PI-103 0 3 72
 8 2.446
1.51
0.227
0.0983
1.57
-0.0288
1.54
0.986
2.66e-06
NA
1.48
0.303
0.906
1.15
0.168
1.59
0.976
1.42e-05
NA
HCC70 PIK-93 1 72
sigmoid
sigmoid
HCC70 PIK-93 0 1 72
 8 1.442
3.47
0.482
0.137
18.6
-1.0
0.656
0.774
0.0116
NA
10.7
0.649
0.904
10.7
0.0
0.632
0.746
0.0163
NA
HCC70 PIK-93 2 72
sigmoid
sigmoid
HCC70 PIK-93 0 2 72
 8 1.705
4.34
0.647
0.0132
9.3
-1.0
1.44
0.888
0.0014
NA
6.01
0.718
0.991
6.01
0.0
1.49
0.872
0.00208
NA
HCC70 PIK-93 3 72
sigmoid
sigmoid
HCC70 PIK-93 0 3 72
 8 2.519
21.2
0.756
0.0663
181.0
-1.0
0.513
0.851
0.00333
NA
34.1
0.721
0.92
34.1
0.0
0.473
0.831
0.00487
NA
HCC70 Sirolimus 1 72
sigmoid
sigmoid
HCC70 rapamycin 0 1 72
 8 1.416
37.6
0.533
0.397
0.00426
0.298
0.1
0.742
0.0172
NA
125000000.0
0.687
0.732
0.00186
0.541
0.1
0.74
0.0175
NA
HCC70 Sirolimus 3 72
sigmoid
sigmoid
HCC70 rapamycin 0 3 72
 8 2.548
310.0
0.732
0.227
0.000433
0.63
0.1
0.676
0.034
NA
22876.0
0.693
0.736
0.000237
0.58
0.1
0.659
0.0397
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
HCC70 TGX221 2 72
sigmoid
sigmoid
HCC70 TGX-221 0 2 72
 8 1.786
1.77
0.467
0.233
0.531
0.227
0.503
0.948
0.000139
NA
5.85
0.575
0.806
3.44
0.0897
0.372
0.937
0.000249
NA
HCC70 TGX221 3 72
sigmoid
sigmoid
HCC70 TGX-221 0 3 72
 8 2.459
Inf
0.7
0.0886
0.338
0.675
1.11
0.971
2.48e-05
NA
Inf
0.671
0.9
0.295
0.648
1.13
0.966
3.94e-05
NA
HCC70 Torin1 1 72
sigmoid
sigmoid
HCC70 Torin1 0 1 72
 8 1.345
0.0472
0.15
0.487
0.0311
0.149
0.849
0.973
1.89e-05
NA
0.93
0.475
0.693
0.0276
0.475
0.854
0.973
2.05e-05
NA
HCC70 Torin1 2 72
sigmoid
sigmoid
HCC70 Torin1 0 2 72
 8 1.726
0.107
0.323
0.391
0.0276
0.322
0.762
0.997
2.34e-08
NA
3.98
0.49
0.694
0.0225
0.491
0.775
0.997
1.93e-08
NA