Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC38 ZSTK474 2 72
sigmoid
sigmoid
HCC38 ZSTK474 0 2 72
 8 2.253
1.63
0.396
0.196
2.18
-0.0865
0.554
0.984
4.3e-06
NA
2.0
0.445
0.803
1.14
0.135
0.556
0.982
5.91e-06
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
HCC70 AS605240 1 72
sigmoid
sigmoid
HCC70 AS-605240 0 1 72
 8 1.387
10.4
0.487
0.159
0.247
0.497
1.34
0.963
5.14e-05
NA
Inf
0.663
0.894
0.23
0.672
1.39
0.961
6.01e-05
NA
HCC70 AS605240 2 72
sigmoid
sigmoid
HCC70 AS-605240 0 2 72
 8 1.771
6.13
0.558
0.126
1.21
0.339
0.698
0.981
7.24e-06
NA
785.0
0.643
0.894
0.946
0.496
0.708
0.978
1.04e-05
NA
HCC70 AS605240 3 72
sigmoid
sigmoid
HCC70 AS-605240 0 3 72
 8 2.447
Inf
0.58
0.112
0.427
0.549
1.18
0.985
3.24e-06
NA
Inf
0.562
0.877
0.345
0.544
1.24
0.982
6.14e-06
NA
HCC70 AZD-6482 1 72
sigmoid
sigmoid
HCC70 AZD6482 0 1 72
 8 1.368
0.0982
0.0128
0.462
0.205
-0.212
0.481
0.975
1.49e-05
NA
0.767
0.394
0.704
0.121
0.305
0.509
0.973
1.9e-05
NA
HCC70 AZD-6482 2 72
sigmoid
sigmoid
HCC70 AZD6482 0 2 72
 8 1.772
0.267
0.256
0.366
0.237
0.0255
0.43
0.987
2.27e-06
NA
1.16
0.438
0.706
0.133
0.306
0.437
0.986
3.03e-06
NA
HCC70 AZD-6482 3 72
sigmoid
sigmoid
HCC70 AZD6482 0 3 72
 8 2.532
1.43
0.435
0.247
0.421
0.226
0.492
0.983
4.63e-06
NA
1.13
0.431
0.729
0.208
0.286
0.5
0.982
6.2e-06
NA
HCC70 AZD8055 1 72
sigmoid
sigmoid
HCC70 AZD8055 0 1 72
 8 1.339
0.0485
0.242
0.442
0.0243
0.26
1.06
0.976
1.32e-05
NA
Inf
0.529
0.721
0.0222
0.54
1.08
0.974
1.81e-05
NA
HCC70 AZD8055 2 72
sigmoid
sigmoid
HCC70 AZD8055 0 2 72
 8 1.724
0.17
0.404
0.346
0.0331
0.385
0.897
0.996
7.36e-08
NA
Inf
0.543
0.728
0.0284
0.531
0.905
0.996
6.22e-08
NA
HCC70 AZD8055 3 72
sigmoid
sigmoid
HCC70 AZD8055 0 3 72
 8 2.442
Inf
0.571
0.287
0.0133
0.574
1.17
0.98
8.55e-06
NA
Inf
0.554
0.694
0.0116
0.556
1.17
0.974
1.69e-05
NA
HCC70 Dactolisib 1 72
sigmoid
sigmoid
HCC70 dactolisib 0 1 72
 8 1.400
0.0808
-0.0667
0.501
3.34
-1.0
0.295
0.963
5.02e-05
NA
0.753
0.344
0.673
0.753
0.0
0.308
0.962
5.37e-05
NA
HCC70 Dactolisib 2 72
sigmoid
sigmoid
HCC70 dactolisib 0 2 72
 8 1.677
0.312
0.238
0.341
0.195
0.103
0.493
0.954
9.66e-05
NA
2.24
0.447
0.738
0.0858
0.419
0.56
0.954
9.8e-05
NA
HCC70 Dactolisib 3 72
sigmoid
sigmoid
HCC70 dactolisib 0 3 72
 8 2.430
0.738
0.321
0.312
18.6
-0.818
0.3
0.975
1.64e-05
NA
0.688
0.365
0.675
0.635
0.0134
0.338
0.97
2.7e-05
NA
HCC70 Buparlisib 1 72
sigmoid
sigmoid
HCC70 buparlisib 0 1 72
 8 1.374
0.608
-0.494
0.231
1.27
-0.9
1.4
0.98
7.6e-06
NA
0.988
0.151
0.861
0.98
0.00578
1.46
0.973
1.91e-05
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
HCC70 Buparlisib 3 72
sigmoid
sigmoid
HCC70 buparlisib 0 3 72
 8 2.439
0.968
-0.156
0.167
1.7
-0.624
1.43
0.995
1.16e-07
NA
0.944
0.122
0.852
0.944
0.0
1.57
0.988
1.57e-06
NA
HCC70 BX-912 1 72
sigmoid
sigmoid
HCC70 BX-912 0 1 72
 8 1.436
1.08
-0.227
0.134
1.2
-0.255
3.86
0.99
1.07e-06
NA
1.35
0.256
0.916
1.14
0.242
3.87
0.986
2.78e-06
NA
HCC70 BX-912 2 72
sigmoid
sigmoid
HCC70 BX-912 0 2 72
 8 1.693
1.25
0.00257
0.0619
1.25
-0.00649
5.0
0.971
2.55e-05
NA
1.44
0.311
0.961
1.2
0.306
5.0
0.956
8.35e-05
NA
HCC70 BX-912 3 72
sigmoid
sigmoid
HCC70 BX-912 0 3 72
 8 2.465
1.26
0.174
0.0739
1.16
0.168
5.0
0.988
1.75e-06
NA
1.26
0.269
0.935
1.08
0.265
5.0
0.977
1.15e-05
NA
HCC70 Alpelisib 1 72
sigmoid
sigmoid
HCC70 alpelisib 0 1 72
 8 1.383
4.4
0.574
0.105
20.4
-1.0
0.717
0.78
0.0106
NA
11.9
0.718
0.929
11.9
0.0
0.732
0.768
0.0124
NA
HCC70 CAL-101 1 72
sigmoid
sigmoid
HCC70 idelalisib 0 1 72
 8 1.384
2.78
0.485
0.0894
0.883
0.424
1.65
0.972
2.11e-05
NA
Inf
0.662
0.941
0.846
0.626
1.66
0.97
2.79e-05
NA
HCC70 CAL-101 2 72
sigmoid
sigmoid
HCC70 idelalisib 0 2 72
 8 1.738
Inf
0.62
0.0432
0.959
0.611
3.13
0.965
4.31e-05
NA
Inf
0.693
0.965
0.935
0.686
3.13
0.96
6.52e-05
NA
HCC70 CAL-101 3 72
sigmoid
sigmoid
HCC70 idelalisib 0 3 72
 8 2.510
Inf
0.724
0.0241
1.39
0.69
2.52
0.964
4.57e-05
NA
Inf
0.689
0.973
1.33
0.655
2.52
0.956
8.64e-05
NA
HCC70 Everolimus 3 72
sigmoid
sigmoid
HCC70 everolimus 0 3 72
 8 2.401
530906.0
0.749
0.195
0.072
0.603
0.1
0.706
0.0255
NA
381983.0
0.725
0.782
0.0137
0.59
0.1
0.706
0.0255
NA