Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
Hs 578T	Buparlisib	3		sigmoid	sigmoid	Hs578T buparlisib 3	8	2.890	0.778	-0.425	0.233	1.71	-1.0	1.4	0.998	1.34e-08	NA	0.622	0.0272	0.779	0.622	0.0	1.57	0.991	8.01e-07	NA
Hs 578T	KIN001-244	3		sigmoid	sigmoid	Hs578T KIN001-244 3	8	2.888	Inf	0.866	0.00909	5.05	0.617	1.35	0.858	0.00289	NA	50.0	0.818	0.988	5.2	0.474	1.31	0.842	0.00391	NA
Hs 578T	AZD8055	3		sigmoid	sigmoid	Hs578T AZD8055 3	8	2.886	0.0538	0.232	0.451	0.0311	0.22	1.06	0.995	1.13e-07	NA	0.039	0.247	0.521	0.0208	0.231	0.989	0.995	1.55e-07	NA
Hs 578T	MK2206	3		sigmoid	sigmoid	Hs578T MK-2206 3	8	2.883	Inf	0.737	0.0965	0.144	0.768	1.94	0.962	5.58e-05	NA	Inf	0.666	0.873	0.135	0.7	1.85	0.967	3.69e-05	NA
HCC1806	Sirolimus	2	72	sigmoid	sigmoid	HCC1806 rapamycin 0 2 72	8	2.881	0.901	0.782	0.182	0.000189	0.714	0.1	0.661	0.0388	NA	149.0	0.717	0.76	0.000153	0.626	0.1	0.634	0.0489	NA
Hs 578T	XL147	3		flat	flat	Hs578T pilaralisib 3	8	2.879	Inf	0.971	-0.00618	0.0	0.971	0.01	0.331	0.299	1.0	Inf	0.959	1.01	0.0	0.959	0.01	0.319	0.315	1.0
Hs 578T	WYE-125132	3		sigmoid	sigmoid	Hs578T WYE-132 3	8	2.876	0.0568	0.189	0.452	0.0346	0.192	0.975	0.996	7.69e-08	NA	0.0403	0.224	0.522	0.0221	0.221	0.97	0.993	4.12e-07	NA
Hs 578T	CAL-101	3		sigmoid	sigmoid	Hs578T idelalisib 3	8	2.874	Inf	0.854	0.0202	1.12	0.835	1.91	0.991	6.68e-07	NA	Inf	0.805	0.972	1.07	0.781	1.92	0.99	9.77e-07	NA
HCC1806	WYE-125132	2	72	sigmoid	sigmoid	HCC1806 WYE-132 0 2 72	8	2.874	0.872	0.479	0.284	0.045	0.464	0.883	0.997	3.66e-08	NA	0.226	0.42	0.663	0.0335	0.402	0.855	0.996	8.79e-08	NA
HCC1806	Everolimus	2	72	sigmoid	sigmoid	HCC1806 everolimus 0 2 72	8	2.871	Inf	0.79	0.178	0.000277	0.79	0.365	0.879	0.00176	NA	Inf	0.727	0.765	0.000222	0.728	0.374	0.879	0.00178	NA
Hs 578T	Omipalisib	3		sigmoid	sigmoid	Hs578T omipalisib 3	8	2.869	0.0255	-0.107	0.615	0.0533	-0.22	0.494	0.99	8.79e-07	NA	0.0145	0.0989	0.392	0.0102	0.0968	0.62	0.993	3.4e-07	NA
HCC1806	Pictilisib	2	72	sigmoid	sigmoid	HCC1806 pictilisib 0 2 72	8	2.866	12.1	0.796	0.0476	45.4	-1.0	0.831	0.811	0.00671	NA	11.3	0.734	0.935	11.3	0.0	0.849	0.773	0.0116	NA
Hs 578T	ZSTK474	3		sigmoid	sigmoid	Hs578T ZSTK474 3	8	2.863	0.913	0.31	0.201	0.613	0.143	0.846	0.999	6.21e-10	NA	0.607	0.298	0.767	0.329	0.211	0.895	0.999	1.43e-09	NA
Hs 578T	Torin1	3		sigmoid	sigmoid	Hs578T Torin1 3	8	2.860	0.0307	0.174	0.514	0.0196	0.176	0.964	0.999	2.01e-09	NA	0.0212	0.218	0.469	0.0119	0.222	1.02	0.998	1.17e-08	NA
HCC1806	Alpelisib	2	72	flat	flat	HCC1806 alpelisib 0 2 72	8	2.856	Inf	0.921	0.0566	0.0	0.921	0.01	-0.336	1.0	0.941	Inf	0.891	0.921	0.0	0.891	0.01	-0.351	1.0	0.919
Hs 578T	Alpelisib	3		sigmoid	sigmoid	Hs578T alpelisib 3	8	2.856	Inf	0.712	0.0759	0.872	0.616	0.828	0.963	5.21e-05	NA	Inf	0.641	0.901	0.65	0.553	0.853	0.955	8.85e-05	NA
Hs 578T	AS605240	3		sigmoid	sigmoid	Hs578T AS-605240 3	8	2.856	63.8	0.588	0.0965	0.826	0.494	1.03	0.983	4.89e-06	NA	5.75	0.518	0.879	0.552	0.465	1.14	0.981	6.87e-06	NA
HCC1806	Omipalisib	2	72	sigmoid	sigmoid	HCC1806 omipalisib 0 2 72	8	2.849	0.112	-0.311	0.479	0.543	-0.739	0.573	0.98	8.07e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
Hs 578T	Everolimus	3		flat	flat	Hs578T everolimus 3	8	2.848	Inf	0.664	0.299	0.0	0.664	0.01	0.475	0.144	0.702	Inf	0.592	0.631	0.0	0.592	0.01	0.486	0.136	0.632
Hs 578T	Torin2	3		sigmoid	sigmoid	Hs578T Torin2 3	8	2.844	0.0272	-0.327	0.667	0.144	-0.614	0.48	0.994	2.62e-07	NA	0.0164	0.0451	0.381	0.0148	0.0308	0.638	0.995	1.07e-07	NA
HCC1806	Torin2	2	72	sigmoid	sigmoid	HCC1806 Torin2 0 2 72	8	2.843	0.0589	-0.181	0.57	0.0771	-0.211	1.3	0.996	6.72e-08	NA	0.0486	0.079	0.492	0.0442	0.0528	1.17	0.995	1.08e-07	NA
HCC1806	Torin1	2	72	sigmoid	sigmoid	HCC1806 Torin1 0 2 72	8	2.840	0.336	0.264	0.309	0.154	0.203	0.668	0.988	1.77e-06	NA	0.186	0.272	0.651	0.0697	0.26	0.75	0.992	4.55e-07	NA
HCC1806	PIK-93	2	72	sigmoid	sigmoid	HCC1806 PIK-93 0 2 72	8	2.838	41.1	0.857	0.038	265.0	-1.0	0.59	0.858	0.00286	NA	46.6	0.811	0.948	46.6	0.0	0.57	0.84	0.00406	NA
Hs 578T	Dactolisib	3		sigmoid	sigmoid	Hs578T dactolisib 3	8	2.837	0.0118	0.0569	0.624	0.00848	0.115	0.799	0.96	6.53e-05	NA	0.00728	0.164	0.377	0.0043	0.212	1.05	0.968	3.34e-05	NA
Hs 578T	Sirolimus	3		flat	flat	Hs578T rapamycin 3	8	2.836	Inf	0.675	0.309	0.0	0.675	0.01	-1.79	1.0	0.691	Inf	0.604	0.621	0.0	0.604	0.01	-3.02	1.0	0.621

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)