Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-549	Alpelisib	1	72	flat	flat	BT549 alpelisib 0 1 72	8	1.822	Inf	0.747	0.0781	0.0	0.747	0.01	0.439	0.176	0.914	Inf	0.782	0.931	0.0	0.782	0.01	0.415	0.2	0.925
HCC38	Dactolisib	1	72	sigmoid	sigmoid	HCC38 dactolisib 0 1 72	8	1.821	0.0109	-0.0403	0.672	0.0104	0.0212	0.892	0.985	3.44e-06	NA	0.0194	0.263	0.492	0.00757	0.301	0.975	0.988	1.65e-06	NA
BT-549	Sirolimus	1	72	sigmoid	sigmoid	BT549 rapamycin 0 1 72	8	1.817	3.62	0.51	0.438	0.000148	0.318	0.1	0.87	0.00218	NA	506850.0	0.6	0.638	8.82e-05	0.447	0.1	0.8	0.00802	NA
BT-549	Trametinib	1	72	sigmoid	sigmoid	BT549 trametinib 0 1 72	8	1.812	Inf	0.596	0.202	0.131	0.523	0.61	0.959	6.65e-05	NA	28.3	0.664	0.828	3.47	0.254	0.337	0.933	0.000305	NA
BT-549	MK2206	1	72	sigmoid	sigmoid	BT549 MK-2206 0 1 72	8	1.811	Inf	0.632	0.189	0.103	0.58	0.8	0.911	0.000695	NA	Inf	0.692	0.839	0.101	0.642	0.73	0.911	0.000717	NA
BT-549	PIK-93	3	72	sigmoid	sigmoid	BT549 PIK-93 0 3 72	8	1.807	20.1	0.719	0.0848	231.0	-1.0	0.45	0.716	0.0229	NA	67.9	0.761	0.925	67.9	0.0	0.431	0.686	0.0309	NA
BT-549	AS605240	1	72	sigmoid	sigmoid	BT549 AS-605240 0 1 72	8	1.804	Inf	0.893	0.0436	4.49	0.778	0.375	0.862	0.00261	NA	Inf	0.905	0.961	4.52	0.804	0.371	0.861	0.00267	NA
BT-549	GDC-0980	3	72	sigmoid	sigmoid	BT549 apitolisib 0 3 72	8	1.802	0.162	0.0283	0.377	0.158	0.0179	1.2	0.994	2.53e-07	NA	0.268	0.302	0.709	0.128	0.294	1.2	0.992	4.85e-07	NA
BT-549	KIN001-244	1	72	sigmoid	sigmoid	BT549 KIN001-244 0 1 72	8	1.802	Inf	0.872	0.0273	4.85	0.695	0.794	0.852	0.00324	NA	Inf	0.888	0.976	4.84	0.733	0.786	0.846	0.00362	NA
BT-549	Dactolisib	3	72	sigmoid	sigmoid	BT549 dactolisib 0 3 72	8	1.801	0.0058	-0.00929	0.751	0.00579	0.000747	0.866	0.994	2.41e-07	NA	0.011	0.282	0.442	0.00425	0.29	0.909	0.995	1.54e-07	NA
HCC70	Alpelisib	2	72	flat	flat	HCC70 alpelisib 0 2 72	8	1.799	Inf	0.748	0.0777	0.0	0.748	0.01	0.00864	0.974	0.907	Inf	0.785	0.932	0.0	0.785	0.01	0.00534	0.984	0.919
BT-549	AZD-6482	1	72	sigmoid	sigmoid	BT549 AZD6482 0 1 72	8	1.798	27.5	0.671	0.115	4.1	0.299	0.478	0.992	4.23e-07	NA	164.0	0.723	0.901	4.18	0.408	0.461	0.992	5.34e-07	NA
BT-20	PIK-93	2	72	sigmoid	sigmoid	BT20 PIK-93 0 2 72	8	1.798	0.792	0.155	0.286	14.1	-1.0	0.382	0.81	0.00687	NA	2.8	0.373	0.764	2.8	0.0	0.344	0.77	0.0121	NA
BT-549	AS605240	3	72	sigmoid	sigmoid	BT549 AS-605240 0 3 72	8	1.796	Inf	0.863	0.066	4.3	0.721	0.307	0.896	0.00112	NA	Inf	0.881	0.942	4.35	0.756	0.302	0.894	0.00118	NA
BT-549	PI103	1	72	sigmoid	sigmoid	BT549 PI-103 0 1 72	8	1.795	0.206	0.0898	0.34	0.185	0.0628	1.25	0.997	2.96e-08	NA	0.348	0.336	0.737	0.155	0.318	1.25	0.996	8.76e-08	NA
BT-549	Buparlisib	3	72	sigmoid	sigmoid	BT549 buparlisib 0 3 72	8	1.795	0.602	-0.351	0.295	1.64	-1.0	1.09	0.983	4.52e-06	NA	0.804	0.132	0.777	0.804	0.0	1.26	0.968	3.41e-05	NA
BT-549	Torin1	1	72	sigmoid	sigmoid	BT549 Torin1 0 1 72	8	1.794	0.017	0.0603	0.621	0.0151	0.056	0.976	0.998	7.25e-09	NA	0.0333	0.32	0.532	0.0118	0.316	0.966	0.998	9.27e-09	NA
BT-20	Torin1	2	72	sigmoid	sigmoid	BT20 Torin1 0 2 72	8	1.793	0.00766	-0.152	0.806	0.00992	-0.146	0.986	0.986	2.59e-06	NA	0.0131	0.215	0.421	0.00727	0.212	0.936	0.988	1.92e-06	NA
BT-549	CAL-101	1	72	sigmoid	sigmoid	BT549 idelalisib 0 1 72	8	1.791	Inf	0.836	0.041	4.8	0.605	0.778	0.924	0.00044	NA	Inf	0.858	0.964	4.79	0.659	0.767	0.92	0.000518	NA
BT-549	Omipalisib	1	72	sigmoid	sigmoid	BT549 omipalisib 0 1 72	8	1.789	0.0164	-0.2	0.693	0.0219	-0.149	0.887	0.986	2.66e-06	NA	0.0272	0.194	0.495	0.0148	0.228	0.993	0.991	8.42e-07	NA
HCC38	MK2206	1	72	sigmoid	sigmoid	HCC38 MK-2206 0 1 72	8	1.789	19.4	0.698	0.0995	320.0	-0.949	0.38	0.956	8.33e-05	NA	61.8	0.746	0.914	61.8	0.0	0.386	0.951	0.000115	NA
HCC70	XL147	2	72	flat	flat	HCC70 pilaralisib 0 2 72	8	1.789	Inf	0.966	0.0311	0.0	0.966	0.01	-0.12	1.0	0.965	Inf	0.97	0.973	0.0	0.97	0.01	-0.121	1.0	0.969
BT-549	WYE-125132	1	72	sigmoid	sigmoid	BT549 WYE-132 0 1 72	8	1.787	0.0317	0.11	0.542	0.026	0.0962	1.09	0.996	5.11e-08	NA	0.062	0.349	0.589	0.0213	0.338	1.05	0.997	3.82e-08	NA
BT-20	ZSTK474	2	72	sigmoid	sigmoid	BT20 ZSTK474 0 2 72	8	1.787	0.286	-0.19	0.347	0.373	-0.234	1.46	0.992	4.53e-07	NA	0.391	0.199	0.743	0.29	0.184	1.55	0.988	1.84e-06	NA
HCC70	TGX221	2	72	sigmoid	sigmoid	HCC70 TGX-221 0 2 72	8	1.786	1.77	0.467	0.233	0.531	0.227	0.503	0.948	0.000139	NA	5.85	0.575	0.806	3.44	0.0897	0.372	0.937	0.000249	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)