Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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Hs 578T | KIN001-244 | 2 | sigmoid | sigmoid | Hs578T KIN001-244 2 | 8 | 2.505 | Inf | 0.819 | 0.0357 | 4.8 | 0.531 | 1.14 | 0.891 | 0.0013 | NA | 44.3 | 0.788 | 0.957 | 4.79 | 0.457 | 1.1 | 0.878 | 0.0018 | NA | |
Hs 578T | MK2206 | 2 | sigmoid | sigmoid | Hs578T MK-2206 2 | 8 | 2.530 | Inf | 0.664 | 0.131 | 0.0699 | 0.752 | 1.34 | 0.75 | 0.0156 | NA | Inf | 0.628 | 0.848 | 0.0616 | 0.717 | 1.21 | 0.767 | 0.0126 | NA | |
Hs 578T | MK2206 | 3 | sigmoid | sigmoid | Hs578T MK-2206 3 | 8 | 2.883 | Inf | 0.737 | 0.0965 | 0.144 | 0.768 | 1.94 | 0.962 | 5.58e-05 | NA | Inf | 0.666 | 0.873 | 0.135 | 0.7 | 1.85 | 0.967 | 3.69e-05 | NA | |
Hs 578T | PI103 | 2 | sigmoid | sigmoid | Hs578T PI-103 2 | 8 | 2.503 | 0.223 | -0.0213 | 0.356 | 0.303 | -0.15 | 0.858 | 0.999 | 7.33e-10 | NA | 0.206 | 0.167 | 0.661 | 0.152 | 0.121 | 0.921 | 0.999 | 1.9e-09 | NA | |
Hs 578T | PI103 | 3 | sigmoid | sigmoid | Hs578T PI-103 3 | 8 | 2.807 | 0.321 | 0.175 | 0.26 | 0.231 | 0.163 | 1.21 | 0.991 | 8.05e-07 | NA | 0.232 | 0.225 | 0.729 | 0.145 | 0.239 | 1.39 | 0.986 | 2.82e-06 | NA | |
Hs 578T | AS605240 | 1 | sigmoid | sigmoid | Hs578T AS-605240 1 | 8 | 2.015 | 0.758 | 0.341 | 0.212 | 0.333 | 0.265 | 0.921 | 0.991 | 7.83e-07 | NA | 1.42 | 0.447 | 0.811 | 0.246 | 0.408 | 0.964 | 0.989 | 1.51e-06 | NA | |
Hs 578T | AS605240 | 2 | sigmoid | sigmoid | Hs578T AS-605240 2 | 8 | 2.547 | 1.89 | 0.43 | 0.194 | 1.81 | 0.011 | 0.541 | 0.988 | 1.81e-06 | NA | 1.6 | 0.426 | 0.784 | 0.971 | 0.117 | 0.532 | 0.983 | 4.67e-06 | NA | |
Hs 578T | AZD-6482 | 1 | sigmoid | sigmoid | Hs578T AZD6482 1 | 8 | 2.041 | 2.04 | 0.401 | 0.177 | 18.5 | -1.0 | 0.498 | 0.986 | 2.92e-06 | NA | 3.16 | 0.484 | 0.835 | 3.16 | 0.0 | 0.532 | 0.98 | 7.93e-06 | NA | |
Hs 578T | AZD-6482 | 2 | sigmoid | sigmoid | Hs578T AZD6482 2 | 8 | 2.508 | 6.35 | 0.602 | 0.121 | 74.8 | -1.0 | 0.445 | 0.998 | 1.12e-08 | NA | 6.4 | 0.573 | 0.86 | 6.4 | 0.0 | 0.475 | 0.996 | 6.36e-08 | NA | |
Hs 578T | AZD8055 | 2 | sigmoid | sigmoid | Hs578T AZD8055 2 | 8 | 2.480 | 0.0521 | 0.149 | 0.469 | 0.0387 | 0.142 | 1.13 | 0.999 | 3.49e-10 | NA | 0.0495 | 0.253 | 0.557 | 0.0273 | 0.249 | 1.16 | 0.999 | 4.45e-10 | NA | |
Hs 578T | AZD8055 | 3 | sigmoid | sigmoid | Hs578T AZD8055 3 | 8 | 2.886 | 0.0538 | 0.232 | 0.451 | 0.0311 | 0.22 | 1.06 | 0.995 | 1.13e-07 | NA | 0.039 | 0.247 | 0.521 | 0.0208 | 0.231 | 0.989 | 0.995 | 1.55e-07 | NA | |
Hs 578T | Dactolisib | 2 | sigmoid | sigmoid | Hs578T dactolisib 2 | 8 | 2.509 | 0.0128 | -0.0617 | 0.655 | 0.0126 | 0.00741 | 0.79 | 0.974 | 1.78e-05 | NA | 0.0105 | 0.15 | 0.405 | 0.00638 | 0.203 | 1.04 | 0.985 | 3.67e-06 | NA | |
Hs 578T | Dactolisib | 3 | sigmoid | sigmoid | Hs578T dactolisib 3 | 8 | 2.837 | 0.0118 | 0.0569 | 0.624 | 0.00848 | 0.115 | 0.799 | 0.96 | 6.53e-05 | NA | 0.00728 | 0.164 | 0.377 | 0.0043 | 0.212 | 1.05 | 0.968 | 3.34e-05 | NA | |
Hs 578T | BX-912 | 1 | sigmoid | sigmoid | Hs578T BX-912 1 | 8 | 2.001 | 0.771 | -0.202 | 0.191 | 1.16 | -0.444 | 1.57 | 0.997 | 2.97e-08 | NA | 0.901 | 0.159 | 0.851 | 0.822 | 0.0702 | 1.64 | 0.994 | 1.9e-07 | NA | |
Hs 578T | BX-912 | 2 | sigmoid | sigmoid | Hs578T BX-912 2 | 8 | 2.540 | 1.07 | -0.019 | 0.174 | 1.79 | -0.489 | 1.33 | 0.998 | 6.37e-09 | NA | 1.01 | 0.164 | 0.828 | 1.01 | 0.0 | 1.4 | 0.996 | 7.64e-08 | NA | |
Hs 578T | Alpelisib | 1 | sigmoid | sigmoid | Hs578T alpelisib 1 | 8 | 2.097 | 2.3 | 0.449 | 0.205 | 42.0 | -1.0 | 0.378 | 0.954 | 9.56e-05 | NA | 3.9 | 0.508 | 0.803 | 3.9 | 0.0 | 0.401 | 0.94 | 0.000216 | NA | |
Hs 578T | Alpelisib | 2 | flat | flat | Hs578T alpelisib 2 | 8 | 2.513 | Inf | 0.668 | 0.131 | 0.0 | 0.668 | 0.01 | 0.599 | 0.0647 | 0.856 | Inf | 0.634 | 0.847 | 0.0 | 0.634 | 0.01 | 0.541 | 0.0969 | 0.833 | |
Hs 578T | CAL-101 | 2 | sigmoid | sigmoid | Hs578T idelalisib 2 | 8 | 2.534 | 57.5 | 0.801 | 0.0636 | 320.0 | -0.507 | 0.408 | 0.979 | 9.58e-06 | NA | Inf | 0.766 | 0.923 | 4.27 | 0.505 | 0.495 | 0.975 | 1.65e-05 | NA | |
Hs 578T | CAL-101 | 3 | sigmoid | sigmoid | Hs578T idelalisib 3 | 8 | 2.874 | Inf | 0.854 | 0.0202 | 1.12 | 0.835 | 1.91 | 0.991 | 6.68e-07 | NA | Inf | 0.805 | 0.972 | 1.07 | 0.781 | 1.92 | 0.99 | 9.77e-07 | NA | |
Hs 578T | Everolimus | 2 | sigmoid | sigmoid | Hs578T everolimus 2 | 8 | 2.550 | 3210000000.0 | 0.626 | 0.335 | 0.000205 | 0.476 | 0.1 | 0.791 | 0.00913 | NA | 18938.0 | 0.59 | 0.627 | 0.000153 | 0.422 | 0.1 | 0.745 | 0.0166 | NA | |
Hs 578T | Everolimus | 3 | flat | flat | Hs578T everolimus 3 | 8 | 2.848 | Inf | 0.664 | 0.299 | 0.0 | 0.664 | 0.01 | 0.475 | 0.144 | 0.702 | Inf | 0.592 | 0.631 | 0.0 | 0.592 | 0.01 | 0.486 | 0.136 | 0.632 | |
Hs 578T | GDC-0980 | 2 | sigmoid | sigmoid | Hs578T apitolisib 2 | 8 | 2.520 | 0.176 | -0.0558 | 0.391 | 0.275 | -0.201 | 0.758 | 0.997 | 3.91e-08 | NA | 0.159 | 0.151 | 0.627 | 0.121 | 0.1 | 0.818 | 0.998 | 1.45e-08 | NA | |
Hs 578T | GDC-0980 | 3 | sigmoid | sigmoid | Hs578T apitolisib 3 | 8 | 2.831 | 0.243 | 0.145 | 0.315 | 0.19 | 0.112 | 1.02 | 0.998 | 4.02e-09 | NA | 0.179 | 0.206 | 0.665 | 0.114 | 0.196 | 1.09 | 0.999 | 9.76e-10 | NA | |
Hs 578T | Sirolimus | 2 | flat | flat | Hs578T rapamycin 2 | 8 | 2.536 | Inf | 0.623 | 0.341 | 0.0 | 0.623 | 0.01 | 0.16 | 0.593 | 0.66 | Inf | 0.589 | 0.623 | 0.0 | 0.589 | 0.01 | -0.232 | 1.0 | 0.624 | |
Hs 578T | Sirolimus | 1 | sigmoid | sigmoid | Hs578T rapamycin 1 | 8 | 2.013 | 110643.0 | 0.587 | 0.358 | 0.000237 | 0.432 | 0.1 | 0.879 | 0.00178 | NA | 9.61e+11 | 0.628 | 0.672 | 0.000175 | 0.487 | 0.1 | 0.851 | 0.00332 | NA |