Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC38 Buparlisib 3 72
sigmoid
sigmoid
HCC38 buparlisib 0 3 72
 8 1.431
0.674
-0.377
0.272
1.67
-1.0
1.21
0.991
6.94e-07
NA
1.11
0.188
0.824
1.11
0.0
1.32
0.987
2.46e-06
NA
HCC70 PIK-93 1 72
sigmoid
sigmoid
HCC70 PIK-93 0 1 72
 8 1.442
3.47
0.482
0.137
18.6
-1.0
0.656
0.774
0.0116
NA
10.7
0.649
0.904
10.7
0.0
0.632
0.746
0.0163
NA
HCC1806 Sirolimus 1 72
sigmoid
sigmoid
HCC1806 rapamycin 0 1 72
 8 2.796
1.35
0.775
0.187
0.00019
0.706
0.1
0.661
0.039
NA
1.05
0.717
0.76
1e-05
0.657
0.1
0.68
0.0328
NA
HCC1806 Sirolimus 3 72
sigmoid
sigmoid
HCC1806 rapamycin 0 3 72
 8 3.249
0.223
0.805
0.162
0.000183
0.746
0.1
0.663
0.0382
NA
1.05
0.717
0.76
1e-05
0.657
0.1
0.68
0.0328
NA
BT-549 PIK-93 2 72
sigmoid
sigmoid
BT549 PIK-93 0 2 72
 8 1.983
7.03
0.687
0.0641
29.9
-1.0
0.759
0.956
8.81e-05
NA
10.4
0.713
0.939
10.4
0.0
0.788
0.949
0.000136
NA
HCC38 PI103 2 72
sigmoid
sigmoid
HCC38 PI-103 0 2 72
 8 2.094
0.856
0.226
0.167
0.672
0.135
1.3
0.986
2.7e-06
NA
1.04
0.359
0.851
0.488
0.33
1.43
0.981
6.52e-06
NA
HCC70 MK2206 2 72
sigmoid
sigmoid
HCC70 MK-2206 0 2 72
 8 1.690
0.446
0.244
0.2
0.301
0.226
1.53
0.973
1.92e-05
NA
1.03
0.448
0.851
0.266
0.44
1.56
0.965
4.11e-05
NA
Hs 578T BX-912 2
sigmoid
sigmoid
Hs578T BX-912 2
 8 2.540
1.07
-0.019
0.174
1.79
-0.489
1.33
0.998
6.37e-09
NA
1.01
0.164
0.828
1.01
0.0
1.4
0.996
7.64e-08
NA
BT-549 ZSTK474 3 72
sigmoid
sigmoid
BT549 ZSTK474 0 3 72
 8 1.776
0.504
0.139
0.267
0.616
-0.0912
0.836
0.996
7.06e-08
NA
0.994
0.368
0.789
0.489
0.218
0.808
0.995
9.19e-08
NA
HCC70 Buparlisib 1 72
sigmoid
sigmoid
HCC70 buparlisib 0 1 72
 8 1.374
0.608
-0.494
0.231
1.27
-0.9
1.4
0.98
7.6e-06
NA
0.988
0.151
0.861
0.98
0.00578
1.46
0.973
1.91e-05
NA
Hs 578T Pictilisib 1
sigmoid
sigmoid
Hs578T pictilisib 1
 8 2.048
0.482
0.341
0.267
0.162
0.295
0.819
0.998
8.97e-09
NA
0.981
0.441
0.759
0.12
0.416
0.847
0.998
6.97e-09
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
HCC38 GDC-0980 3 72
sigmoid
sigmoid
HCC38 apitolisib 0 3 72
 8 1.437
0.371
-0.0189
0.29
0.513
-0.179
0.946
0.993
3.35e-07
NA
0.96
0.359
0.808
0.393
0.295
0.998
0.993
3.51e-07
NA
HCC38 Buparlisib 2 72
sigmoid
sigmoid
HCC38 buparlisib 0 2 72
 8 2.142
0.876
-0.185
0.172
1.24
-0.413
1.74
0.996
5.03e-08
NA
0.959
0.146
0.861
0.893
0.0606
1.8
0.992
4.3e-07
NA
BT-549 ZSTK474 2 72
sigmoid
sigmoid
BT549 ZSTK474 0 2 72
 8 1.962
0.628
0.144
0.245
0.841
-0.139
0.84
0.995
1.29e-07
NA
0.958
0.334
0.791
0.595
0.163
0.828
0.992
4.28e-07
NA
HCC1806 GDC-0980 1 72
sigmoid
sigmoid
HCC1806 apitolisib 0 1 72
 8 2.696
1.24
0.339
0.152
0.739
0.223
1.15
0.995
1.52e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC1806 GDC-0980 3 72
sigmoid
sigmoid
HCC1806 apitolisib 0 3 72
 8 3.149
1.8
0.418
0.132
0.77
0.31
1.14
0.995
1.41e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC1806 GDC-0980 2 72
sigmoid
sigmoid
HCC1806 apitolisib 0 2 72
 8 2.781
1.32
0.355
0.148
0.746
0.241
1.15
0.995
1.49e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC70 Buparlisib 3 72
sigmoid
sigmoid
HCC70 buparlisib 0 3 72
 8 2.439
0.968
-0.156
0.167
1.7
-0.624
1.43
0.995
1.16e-07
NA
0.944
0.122
0.852
0.944
0.0
1.57
0.988
1.57e-06
NA
BT-20 ZSTK474 1 72
sigmoid
sigmoid
BT20 ZSTK474 0 1 72
 8 1.940
0.788
0.0217
0.122
0.819
-0.0395
1.99
0.957
7.76e-05
NA
0.942
0.272
0.913
0.677
0.249
2.09
0.934
0.000293
NA
Hs 578T BX-912 3
sigmoid
sigmoid
Hs578T BX-912 3
 8 2.805
1.04
0.0121
0.125
1.09
-0.0661
2.36
0.992
4.22e-07
NA
0.936
0.148
0.883
0.841
0.116
2.45
0.982
5.7e-06
NA
HCC70 Torin1 1 72
sigmoid
sigmoid
HCC70 Torin1 0 1 72
 8 1.345
0.0472
0.15
0.487
0.0311
0.149
0.849
0.973
1.89e-05
NA
0.93
0.475
0.693
0.0276
0.475
0.854
0.973
2.05e-05
NA
BT-549 Buparlisib 1 72
sigmoid
sigmoid
BT549 buparlisib 0 1 72
 8 1.837
0.729
-0.325
0.253
1.83
-1.0
1.19
0.994
2.4e-07
NA
0.926
0.136
0.807
0.926
0.0
1.37
0.987
2.46e-06
NA
HCC70 MK2206 1 72
sigmoid
sigmoid
HCC70 MK-2206 0 1 72
 8 1.444
0.314
-0.0266
0.337
0.618
-0.336
0.758
0.991
6.35e-07
NA
0.925
0.353
0.775
0.521
0.172
0.737
0.99
1.08e-06
NA
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA