Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
Download: Excel (XLSX), Comma-separated (CSV)
Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BT-20 | TGX221 | 1 | 72 | flat | flat | BT20 TGX-221 0 1 72 | 8 | 1.988 | Inf | 1.02 | -0.00357 | 0.0 | 1.02 | 0.01 | -0.00762 | 1.0 | 1.0 | Inf | 1.02 | 1.0 | 0.0 | 1.02 | 0.01 | -0.00881 | 1.0 | 1.0 |
BT-20 | TGX221 | 2 | 72 | flat | flat | BT20 TGX-221 0 2 72 | 8 | 1.656 | Inf | 1.0 | 0.0477 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.946 | Inf | 1.0 | 0.961 | 0.0 | 1.0 | 0.01 | -0.101 | 1.0 | 0.956 |
BT-20 | TGX221 | 3 | 72 | flat | flat | BT20 TGX-221 0 3 72 | 8 | 2.469 | Inf | 1.01 | 0.0147 | 0.0 | 1.01 | 0.01 | -0.0563 | 1.0 | 0.982 | Inf | 1.01 | 0.983 | 0.0 | 1.01 | 0.01 | -0.0552 | 1.0 | 0.979 |
BT-20 | Everolimus | 3 | 72 | flat | flat | BT20 everolimus 0 3 72 | 8 | 2.422 | Inf | 0.475 | 0.456 | 0.0 | 0.475 | 0.01 | 0.602 | 0.0632 | 0.543 | Inf | 0.478 | 0.534 | 0.0 | 0.478 | 0.01 | 0.561 | 0.0844 | 0.534 |
HCC38 | AZD-6482 | 1 | 72 | sigmoid | sigmoid | HCC38 AZD6482 0 1 72 | 8 | 1.732 | Inf | 0.862 | 0.0239 | 1.4 | 0.804 | 1.03 | 0.909 | 0.000761 | NA | Inf | 0.883 | 0.98 | 1.34 | 0.837 | 1.03 | 0.904 | 0.000873 | NA |
BT-549 | XL147 | 3 | 72 | flat | flat | BT549 pilaralisib 0 3 72 | 8 | 1.772 | Inf | 0.933 | 0.0351 | 0.0 | 0.933 | 0.01 | -0.0699 | 1.0 | 0.962 | Inf | 0.941 | 0.969 | 0.0 | 0.941 | 0.01 | -0.0712 | 1.0 | 0.967 |
BT-549 | Trametinib | 3 | 72 | sigmoid | sigmoid | BT549 trametinib 0 3 72 | 8 | 1.755 | Inf | 0.553 | 0.223 | 0.107 | 0.505 | 0.899 | 0.942 | 0.000194 | NA | Inf | 0.642 | 0.817 | 0.104 | 0.595 | 0.804 | 0.938 | 0.000236 | NA |
BT-20 | KIN001-244 | 2 | 72 | sigmoid | sigmoid | BT20 KIN001-244 0 2 72 | 8 | 1.742 | Inf | 0.85 | 0.0644 | 4.47 | 0.713 | 0.316 | 0.721 | 0.0218 | NA | Inf | 0.873 | 0.945 | 4.51 | 0.757 | 0.309 | 0.715 | 0.0231 | NA |
BT-549 | KIN001-244 | 3 | 72 | sigmoid | sigmoid | BT549 KIN001-244 0 3 72 | 8 | 1.740 | Inf | 0.861 | 0.0287 | 4.69 | 0.681 | 0.74 | 0.922 | 0.00047 | NA | Inf | 0.882 | 0.975 | 4.7 | 0.729 | 0.732 | 0.919 | 0.000531 | NA |
BT-549 | TGX221 | 1 | 72 | sigmoid | sigmoid | BT549 TGX-221 0 1 72 | 8 | 1.826 | Inf | 0.821 | 0.0771 | 0.297 | 0.777 | 0.632 | 0.868 | 0.00232 | NA | Inf | 0.842 | 0.931 | 0.313 | 0.799 | 0.603 | 0.863 | 0.00255 | NA |
BT-549 | CAL-101 | 2 | 72 | sigmoid | sigmoid | BT549 idelalisib 0 2 72 | 8 | 1.975 | Inf | 0.792 | 0.0561 | 4.65 | 0.526 | 0.693 | 0.933 | 0.000307 | NA | 43.0 | 0.805 | 0.946 | 43.0 | 0.0 | 0.548 | 0.932 | 0.000314 | NA |
BT-20 | Trametinib | 3 | 72 | sigmoid | sigmoid | BT20 trametinib 0 3 72 | 8 | 2.539 | Inf | 0.64 | 0.208 | 0.104 | 0.541 | 0.392 | 0.967 | 3.69e-05 | NA | Inf | 0.604 | 0.761 | 0.0656 | 0.513 | 0.391 | 0.964 | 4.56e-05 | NA |
BT-20 | BX-912 | 1 | 72 | flat | flat | BT20 BX-912 0 1 72 | 8 | 2.193 | Inf | 0.858 | 0.0928 | 0.0 | 0.858 | 0.01 | 0.25 | 0.422 | 0.903 | Inf | 0.851 | 0.901 | 0.0 | 0.851 | 0.01 | 0.243 | 0.433 | 0.897 |
BT-549 | Alpelisib | 3 | 72 | flat | flat | BT549 alpelisib 0 3 72 | 8 | 1.743 | Inf | 0.817 | 0.068 | 0.0 | 0.817 | 0.01 | -0.0192 | 1.0 | 0.915 | Inf | 0.846 | 0.942 | 0.0 | 0.846 | 0.01 | -0.0162 | 1.0 | 0.928 |
BT-20 | AS605240 | 1 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 1 72 | 8 | 2.142 | Inf | 0.817 | 0.0993 | 3.91 | 0.634 | 0.244 | 0.861 | 0.00271 | NA | Inf | 0.814 | 0.897 | 3.87 | 0.629 | 0.237 | 0.854 | 0.00311 | NA |
BT-20 | XL147 | 1 | 72 | flat | flat | BT20 pilaralisib 0 1 72 | 8 | 2.128 | Inf | 0.815 | 0.048 | 0.0 | 0.815 | 0.01 | 0.411 | 0.205 | 0.939 | Inf | 0.813 | 0.95 | 0.0 | 0.813 | 0.01 | 0.383 | 0.234 | 0.937 |
BT-20 | XL147 | 2 | 72 | flat | flat | BT20 pilaralisib 0 2 72 | 8 | 1.784 | Inf | 0.759 | 0.073 | 0.0 | 0.759 | 0.01 | -0.0058 | 1.0 | 0.907 | Inf | 0.796 | 0.937 | 0.0 | 0.796 | 0.01 | -0.00637 | 1.0 | 0.92 |
BT-20 | XL147 | 3 | 72 | flat | flat | BT20 pilaralisib 0 3 72 | 8 | 2.647 | Inf | 0.755 | 0.102 | 0.0 | 0.755 | 0.01 | 0.0679 | 0.81 | 0.885 | Inf | 0.708 | 0.871 | 0.0 | 0.708 | 0.01 | 0.0505 | 0.856 | 0.857 |
BT-549 | CAL-101 | 1 | 72 | sigmoid | sigmoid | BT549 idelalisib 0 1 72 | 8 | 1.791 | Inf | 0.836 | 0.041 | 4.8 | 0.605 | 0.778 | 0.924 | 0.00044 | NA | Inf | 0.858 | 0.964 | 4.79 | 0.659 | 0.767 | 0.92 | 0.000518 | NA |
BT-549 | Everolimus | 2 | 72 | flat | flat | BT549 everolimus 0 2 72 | 8 | 1.909 | Inf | 0.566 | 0.407 | 0.0 | 0.566 | 0.01 | -0.646 | 1.0 | 0.594 | Inf | 0.627 | 0.648 | 0.0 | 0.627 | 0.01 | -1.01 | 1.0 | 0.649 |
BT-20 | BX-912 | 3 | 72 | flat | flat | BT20 BX-912 0 3 72 | 8 | 2.619 | Inf | 0.904 | 0.0795 | 0.0 | 0.904 | 0.01 | 0.000173 | 0.999 | 0.918 | Inf | 0.879 | 0.9 | 0.0 | 0.879 | 0.01 | 0.00619 | 0.982 | 0.896 |
BT-549 | AS605240 | 1 | 72 | sigmoid | sigmoid | BT549 AS-605240 0 1 72 | 8 | 1.804 | Inf | 0.893 | 0.0436 | 4.49 | 0.778 | 0.375 | 0.862 | 0.00261 | NA | Inf | 0.905 | 0.961 | 4.52 | 0.804 | 0.371 | 0.861 | 0.00267 | NA |
BT-549 | AS605240 | 2 | 72 | flat | flat | BT549 AS-605240 0 2 72 | 8 | 1.961 | Inf | 0.91 | 0.0479 | 0.0 | 0.91 | 0.01 | 0.414 | 0.201 | 0.949 | Inf | 0.914 | 0.954 | 0.0 | 0.914 | 0.01 | 0.418 | 0.197 | 0.951 |
HCC70 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 3 72 | 8 | 2.442 | Inf | 0.571 | 0.287 | 0.0133 | 0.574 | 1.17 | 0.98 | 8.55e-06 | NA | Inf | 0.554 | 0.694 | 0.0116 | 0.556 | 1.17 | 0.974 | 1.69e-05 | NA |
HCC70 | AS605240 | 3 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 3 72 | 8 | 2.447 | Inf | 0.58 | 0.112 | 0.427 | 0.549 | 1.18 | 0.985 | 3.24e-06 | NA | Inf | 0.562 | 0.877 | 0.345 | 0.544 | 1.24 | 0.982 | 6.14e-06 | NA |