Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
HCC70 Buparlisib 1 72
sigmoid
sigmoid
HCC70 buparlisib 0 1 72
 8 1.374
0.608
-0.494
0.231
1.27
-0.9
1.4
0.98
7.6e-06
NA
0.988
0.151
0.861
0.98
0.00578
1.46
0.973
1.91e-05
NA
HCC1806 WYE-125132 1 72
sigmoid
sigmoid
HCC1806 WYE-132 0 1 72
 8 2.790
0.603
0.466
0.292
0.0448
0.45
0.883
0.997
3.72e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
BT-549 Buparlisib 3 72
sigmoid
sigmoid
BT549 buparlisib 0 3 72
 8 1.795
0.602
-0.351
0.295
1.64
-1.0
1.09
0.983
4.52e-06
NA
0.804
0.132
0.777
0.804
0.0
1.26
0.968
3.41e-05
NA
BT-20 Buparlisib 1 72
sigmoid
sigmoid
BT20 buparlisib 0 1 72
 8 2.131
0.598
-0.394
0.285
1.19
-0.763
1.35
0.992
4.68e-07
NA
0.663
0.0784
0.766
0.663
0.0
1.49
0.981
7.06e-06
NA
HCC38 BX-912 2 72
sigmoid
sigmoid
HCC38 BX-912 0 2 72
 8 2.186
0.583
-0.229
0.251
0.648
-0.233
3.62
0.999
9.58e-10
NA
0.602
0.124
0.807
0.559
0.123
3.78
0.998
1.03e-08
NA
BT-20 AZD-6482 2 72
sigmoid
sigmoid
BT20 AZD6482 0 2 72
 8 1.645
0.581
0.0253
0.303
3.86
-1.0
0.58
0.904
0.000884
NA
1.34
0.333
0.772
1.34
0.0
0.582
0.864
0.0025
NA
BT-549 ZSTK474 1 72
sigmoid
sigmoid
BT549 ZSTK474 0 1 72
 8 1.861
0.58
0.213
0.256
0.583
-0.00205
0.771
0.992
5.43e-07
NA
1.12
0.394
0.788
0.428
0.261
0.767
0.989
1.49e-06
NA
Hs 578T Buparlisib 1
sigmoid
sigmoid
Hs578T buparlisib 1
 8 2.064
0.55
-0.579
0.308
1.29
-1.0
1.29
0.992
4.22e-07
NA
0.587
0.0401
0.759
0.587
0.0
1.31
0.988
1.94e-06
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
HCC1806 Torin1 3 72
sigmoid
sigmoid
HCC1806 Torin1 0 3 72
 8 3.208
0.537
0.332
0.278
0.165
0.271
0.662
0.988
1.91e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
HCC38 BX-912 1 72
sigmoid
sigmoid
HCC38 BX-912 0 1 72
 8 1.760
0.529
-0.322
0.274
0.591
-0.322
4.49
0.999
1.36e-10
NA
0.584
0.149
0.818
0.541
0.149
4.63
0.999
8.39e-10
NA
HCC70 Trametinib 2 72
sigmoid
sigmoid
HCC70 trametinib 0 2 72
 8 1.721
0.506
0.504
0.395
0.00469
0.467
0.581
0.944
0.000179
NA
Inf
0.612
0.687
0.00389
0.585
0.57
0.948
0.000138
NA
BT-549 ZSTK474 3 72
sigmoid
sigmoid
BT549 ZSTK474 0 3 72
 8 1.776
0.504
0.139
0.267
0.616
-0.0912
0.836
0.996
7.06e-08
NA
0.994
0.368
0.789
0.489
0.218
0.808
0.995
9.19e-08
NA
Hs 578T Pictilisib 1
sigmoid
sigmoid
Hs578T pictilisib 1
 8 2.048
0.482
0.341
0.267
0.162
0.295
0.819
0.998
8.97e-09
NA
0.981
0.441
0.759
0.12
0.416
0.847
0.998
6.97e-09
NA
BT-20 ZSTK474 3 72
sigmoid
sigmoid
BT20 ZSTK474 0 3 72
 8 2.609
0.457
-0.00222
0.296
0.783
-0.31
0.895
0.982
5.76e-06
NA
0.422
0.163
0.702
0.422
0.0
0.82
0.971
2.52e-05
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
HCC70 MK2206 2 72
sigmoid
sigmoid
HCC70 MK-2206 0 2 72
 8 1.690
0.446
0.244
0.2
0.301
0.226
1.53
0.973
1.92e-05
NA
1.03
0.448
0.851
0.266
0.44
1.56
0.965
4.11e-05
NA
HCC38 BX-912 3 72
sigmoid
sigmoid
HCC38 BX-912 0 3 72
 8 1.454
0.422
-0.428
0.365
0.478
-0.433
5.0
0.993
4.02e-07
NA
0.496
0.162
0.778
0.46
0.159
5.0
0.989
1.24e-06
NA
HCC70 Pictilisib 1 72
sigmoid
sigmoid
HCC70 pictilisib 0 1 72
 8 1.409
0.408
-0.099
0.284
0.578
-0.245
1.14
0.996
7.62e-08
NA
0.888
0.325
0.816
0.477
0.261
1.19
0.995
1.2e-07
NA
BT-20 PI103 3 72
sigmoid
sigmoid
BT20 PI-103 0 3 72
 8 2.496
0.373
0.0139
0.282
0.387
-0.0286
1.52
0.994
1.99e-07
NA
0.359
0.183
0.735
0.279
0.162
1.56
0.988
1.71e-06
NA
HCC38 GDC-0980 3 72
sigmoid
sigmoid
HCC38 apitolisib 0 3 72
 8 1.437
0.371
-0.0189
0.29
0.513
-0.179
0.946
0.993
3.35e-07
NA
0.96
0.359
0.808
0.393
0.295
0.998
0.993
3.51e-07
NA
HCC1806 Torin1 2 72
sigmoid
sigmoid
HCC1806 Torin1 0 2 72
 8 2.840
0.336
0.264
0.309
0.154
0.203
0.668
0.988
1.77e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
BT-20 Buparlisib 2 72
sigmoid
sigmoid
BT20 buparlisib 0 2 72
 8 1.743
0.334
-0.45
0.391
0.844
-0.82
1.05
0.972
2.21e-05
NA
0.487
0.105
0.718
0.487
0.0
1.12
0.948
0.000142
NA
HCC38 GDC-0980 2 72
sigmoid
sigmoid
HCC38 apitolisib 0 2 72
 8 2.159
0.33
0.153
0.279
0.253
0.117
1.0
0.992
4.91e-07
NA
0.385
0.304
0.749
0.165
0.308
1.13
0.994
2.09e-07
NA