Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 WYE-125132 2 72
sigmoid
sigmoid
HCC1806 WYE-132 0 2 72
 8 2.874
0.872
0.479
0.284
0.045
0.464
0.883
0.997
3.66e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
HCC38 PI103 2 72
sigmoid
sigmoid
HCC38 PI-103 0 2 72
 8 2.094
0.856
0.226
0.167
0.672
0.135
1.3
0.986
2.7e-06
NA
1.04
0.359
0.851
0.488
0.33
1.43
0.981
6.52e-06
NA
BT-20 Pictilisib 3 72
sigmoid
sigmoid
BT20 pictilisib 0 3 72
 8 2.566
0.839
0.172
0.22
0.914
-0.0483
1.09
0.954
9.59e-05
NA
0.843
0.254
0.768
0.809
0.0179
0.898
0.918
0.000551
NA
BT-20 MK2206 2 72
sigmoid
sigmoid
BT20 MK-2206 0 2 72
 8 1.739
0.823
0.0896
0.246
4.34
-1.0
0.661
0.965
4.36e-05
NA
1.47
0.348
0.806
1.47
0.0
0.715
0.947
0.000145
NA
HCC70 Pictilisib 2 72
sigmoid
sigmoid
HCC70 pictilisib 0 2 72
 8 1.783
0.811
0.124
0.189
0.858
-0.0372
1.27
0.973
2.08e-05
NA
1.25
0.358
0.852
0.678
0.278
1.32
0.963
5.09e-05
NA
HCC1806 Buparlisib 3 72
sigmoid
sigmoid
HCC1806 buparlisib 0 3 72
 8 3.195
0.808
-0.257
0.203
0.96
-0.303
2.74
1.0
2.03e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
BT-20 PIK-93 2 72
sigmoid
sigmoid
BT20 PIK-93 0 2 72
 8 1.798
0.792
0.155
0.286
14.1
-1.0
0.382
0.81
0.00687
NA
2.8
0.373
0.764
2.8
0.0
0.344
0.77
0.0121
NA
BT-20 ZSTK474 1 72
sigmoid
sigmoid
BT20 ZSTK474 0 1 72
 8 1.940
0.788
0.0217
0.122
0.819
-0.0395
1.99
0.957
7.76e-05
NA
0.942
0.272
0.913
0.677
0.249
2.09
0.934
0.000293
NA
Hs 578T Buparlisib 3
sigmoid
sigmoid
Hs578T buparlisib 3
 8 2.890
0.778
-0.425
0.233
1.71
-1.0
1.4
0.998
1.34e-08
NA
0.622
0.0272
0.779
0.622
0.0
1.57
0.991
8.01e-07
NA
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA
BT-20 Trametinib 2 72
sigmoid
sigmoid
BT20 trametinib 0 2 72
 8 1.723
0.761
0.303
0.289
11.1
-0.768
0.347
0.965
4.13e-05
NA
2.56
0.478
0.77
2.56
0.0
0.362
0.957
8.16e-05
NA
HCC1806 Buparlisib 2 72
sigmoid
sigmoid
HCC1806 buparlisib 0 2 72
 8 2.827
0.759
-0.346
0.221
0.937
-0.392
2.75
1.0
2.72e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
Hs 578T AS605240 1
sigmoid
sigmoid
Hs578T AS-605240 1
 8 2.015
0.758
0.341
0.212
0.333
0.265
0.921
0.991
7.83e-07
NA
1.42
0.447
0.811
0.246
0.408
0.964
0.989
1.51e-06
NA
HCC38 PI103 1 72
sigmoid
sigmoid
HCC38 PI-103 0 1 72
 8 1.782
0.755
0.222
0.201
0.601
0.12
1.2
0.996
4.45e-08
NA
1.39
0.416
0.839
0.494
0.359
1.23
0.995
1.01e-07
NA
HCC1806 Buparlisib 1 72
sigmoid
sigmoid
HCC1806 buparlisib 0 1 72
 8 2.742
0.748
-0.369
0.226
0.931
-0.415
2.75
1.0
2.95e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC70 Dactolisib 3 72
sigmoid
sigmoid
HCC70 dactolisib 0 3 72
 8 2.430
0.738
0.321
0.312
18.6
-0.818
0.3
0.975
1.64e-05
NA
0.688
0.365
0.675
0.635
0.0134
0.338
0.97
2.7e-05
NA
BT-549 Buparlisib 1 72
sigmoid
sigmoid
BT549 buparlisib 0 1 72
 8 1.837
0.729
-0.325
0.253
1.83
-1.0
1.19
0.994
2.4e-07
NA
0.926
0.136
0.807
0.926
0.0
1.37
0.987
2.46e-06
NA
Hs 578T ZSTK474 2
sigmoid
sigmoid
Hs578T ZSTK474 2
 8 2.554
0.715
0.187
0.263
5.92
-0.896
0.485
0.995
1.27e-07
NA
0.583
0.264
0.722
0.583
0.0
0.56
0.993
3.28e-07
NA
BT-549 Buparlisib 2 72
sigmoid
sigmoid
BT549 buparlisib 0 2 72
 8 1.913
0.681
-0.306
0.217
1.08
-0.538
1.59
0.998
1.31e-08
NA
0.821
0.132
0.838
0.769
0.0514
1.66
0.996
8.95e-08
NA
HCC38 Buparlisib 3 72
sigmoid
sigmoid
HCC38 buparlisib 0 3 72
 8 1.431
0.674
-0.377
0.272
1.67
-1.0
1.21
0.991
6.94e-07
NA
1.11
0.188
0.824
1.11
0.0
1.32
0.987
2.46e-06
NA
Hs 578T Buparlisib 2
sigmoid
sigmoid
Hs578T buparlisib 2
 8 2.513
0.665
-0.42
0.251
1.61
-1.0
1.24
0.998
1.14e-08
NA
0.595
0.0445
0.779
0.595
0.0
1.36
0.994
2.48e-07
NA
BT-20 PI103 1 72
sigmoid
sigmoid
BT20 PI-103 0 1 72
 8 1.924
0.646
-0.0114
0.16
0.659
-0.0268
2.6
0.978
1.1e-05
NA
0.753
0.258
0.883
0.579
0.252
2.68
0.964
4.79e-05
NA
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
 8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
BT-549 ZSTK474 2 72
sigmoid
sigmoid
BT549 ZSTK474 0 2 72
 8 1.962
0.628
0.144
0.245
0.841
-0.139
0.84
0.995
1.29e-07
NA
0.958
0.334
0.791
0.595
0.163
0.828
0.992
4.28e-07
NA