Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC38 | KIN001-244 | 1 | 72 | sigmoid | sigmoid | HCC38 KIN001-244 0 1 72 | 8 | 1.751 | Inf | 0.894 | 0.0375 | 4.46 | 0.77 | 0.479 | 0.71 | 0.0244 | NA | Inf | 0.909 | 0.968 | 4.5 | 0.802 | 0.474 | 0.705 | 0.0256 | NA |
HCC1806 | Pictilisib | 1 | 72 | sigmoid | sigmoid | HCC1806 pictilisib 0 1 72 | 8 | 2.782 | 11.7 | 0.79 | 0.049 | 43.7 | -1.0 | 0.831 | 0.811 | 0.00677 | NA | 11.3 | 0.734 | 0.935 | 11.3 | 0.0 | 0.849 | 0.773 | 0.0116 | NA |
BT-20 | MK2206 | 2 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 2 72 | 8 | 1.739 | 0.823 | 0.0896 | 0.246 | 4.34 | -1.0 | 0.661 | 0.965 | 4.36e-05 | NA | 1.47 | 0.348 | 0.806 | 1.47 | 0.0 | 0.715 | 0.947 | 0.000145 | NA |
BT-549 | AS605240 | 3 | 72 | sigmoid | sigmoid | BT549 AS-605240 0 3 72 | 8 | 1.796 | Inf | 0.863 | 0.066 | 4.3 | 0.721 | 0.307 | 0.896 | 0.00112 | NA | Inf | 0.881 | 0.942 | 4.35 | 0.756 | 0.302 | 0.894 | 0.00118 | NA |
BT-549 | Alpelisib | 2 | 72 | sigmoid | sigmoid | BT549 alpelisib 0 2 72 | 8 | 1.927 | Inf | 0.832 | 0.0409 | 4.24 | 0.663 | 0.548 | 0.706 | 0.0254 | NA | Inf | 0.844 | 0.962 | 4.26 | 0.686 | 0.542 | 0.696 | 0.0282 | NA |
Hs 578T | Alpelisib | 1 | sigmoid | sigmoid | Hs578T alpelisib 1 | 8 | 2.097 | 2.3 | 0.449 | 0.205 | 42.0 | -1.0 | 0.378 | 0.954 | 9.56e-05 | NA | 3.9 | 0.508 | 0.803 | 3.9 | 0.0 | 0.401 | 0.94 | 0.000216 | NA | |
BT-20 | MK2206 | 1 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 1 72 | 8 | 2.089 | Inf | 0.732 | 0.102 | 4.16 | 0.529 | 0.345 | 0.671 | 0.0357 | NA | Inf | 0.741 | 0.898 | 4.14 | 0.538 | 0.337 | 0.676 | 0.034 | NA |
BT-20 | AS605240 | 3 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 3 72 | 8 | 2.607 | Inf | 0.845 | 0.0823 | 4.13 | 0.662 | 0.292 | 0.729 | 0.0199 | NA | Inf | 0.81 | 0.897 | 3.97 | 0.589 | 0.284 | 0.712 | 0.0239 | NA |
BT-549 | AZD-6482 | 1 | 72 | sigmoid | sigmoid | BT549 AZD6482 0 1 72 | 8 | 1.798 | 27.5 | 0.671 | 0.115 | 4.1 | 0.299 | 0.478 | 0.992 | 4.23e-07 | NA | 164.0 | 0.723 | 0.901 | 4.18 | 0.408 | 0.461 | 0.992 | 5.34e-07 | NA |
HCC38 | CAL-101 | 3 | 72 | sigmoid | sigmoid | HCC38 idelalisib 0 3 72 | 8 | 1.443 | Inf | 0.851 | 0.0804 | 4.08 | 0.726 | 0.225 | 0.706 | 0.0254 | NA | Inf | 0.894 | 0.943 | 4.27 | 0.804 | 0.222 | 0.707 | 0.0252 | NA |
HCC38 | AS605240 | 2 | 72 | sigmoid | sigmoid | HCC38 AS-605240 0 2 72 | 8 | 2.200 | 17.4 | 0.642 | 0.114 | 4.07 | 0.256 | 0.493 | 0.936 | 0.000265 | NA | 46.2 | 0.648 | 0.882 | 1.68 | 0.411 | 0.522 | 0.929 | 0.000356 | NA |
Hs 578T | KIN001-244 | 1 | sigmoid | sigmoid | Hs578T KIN001-244 1 | 8 | 2.041 | 24.7 | 0.739 | 0.0391 | 4.05 | 0.414 | 0.972 | 0.968 | 3.4e-05 | NA | Inf | 0.752 | 0.962 | 3.15 | 0.51 | 0.99 | 0.964 | 4.65e-05 | NA | |
BT-20 | AS605240 | 1 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 1 72 | 8 | 2.142 | Inf | 0.817 | 0.0993 | 3.91 | 0.634 | 0.244 | 0.861 | 0.00271 | NA | Inf | 0.814 | 0.897 | 3.87 | 0.629 | 0.237 | 0.854 | 0.00311 | NA |
BT-20 | AZD-6482 | 2 | 72 | sigmoid | sigmoid | BT20 AZD6482 0 2 72 | 8 | 1.645 | 0.581 | 0.0253 | 0.303 | 3.86 | -1.0 | 0.58 | 0.904 | 0.000884 | NA | 1.34 | 0.333 | 0.772 | 1.34 | 0.0 | 0.582 | 0.864 | 0.0025 | NA |
BT-20 | AZD-6482 | 1 | 72 | sigmoid | sigmoid | BT20 AZD6482 0 1 72 | 8 | 2.043 | 1.34 | 0.182 | 0.173 | 3.83 | -0.782 | 0.893 | 0.982 | 5.6e-06 | NA | 1.65 | 0.342 | 0.845 | 1.65 | 0.0 | 0.977 | 0.972 | 2.09e-05 | NA |
Hs 578T | PIK-93 | 2 | sigmoid | sigmoid | Hs578T PIK-93 2 | 8 | 2.467 | 2.43 | 0.415 | 0.0931 | 3.62 | -0.243 | 0.991 | 0.991 | 8.05e-07 | NA | 2.34 | 0.426 | 0.901 | 1.93 | 0.0909 | 1.04 | 0.987 | 2.24e-06 | NA | |
BT-20 | Alpelisib | 1 | 72 | sigmoid | sigmoid | BT20 alpelisib 0 1 72 | 8 | 2.077 | 1.14 | 0.046 | 0.196 | 3.52 | -1.0 | 0.977 | 0.966 | 4.1e-05 | NA | 1.32 | 0.26 | 0.825 | 1.32 | 0.0 | 1.13 | 0.942 | 0.000194 | NA |
HCC70 | Dactolisib | 1 | 72 | sigmoid | sigmoid | HCC70 dactolisib 0 1 72 | 8 | 1.400 | 0.0808 | -0.0667 | 0.501 | 3.34 | -1.0 | 0.295 | 0.963 | 5.02e-05 | NA | 0.753 | 0.344 | 0.673 | 0.753 | 0.0 | 0.308 | 0.962 | 5.37e-05 | NA |
BT-20 | MK2206 | 3 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 3 72 | 8 | 2.449 | 1.73 | 0.252 | 0.12 | 3.23 | -0.504 | 1.11 | 0.988 | 1.77e-06 | NA | 1.69 | 0.318 | 0.877 | 1.69 | 0.0 | 1.18 | 0.979 | 9.03e-06 | NA |
BT-549 | CAL-101 | 3 | 72 | sigmoid | sigmoid | BT549 idelalisib 0 3 72 | 8 | 1.770 | 43.0 | 0.79 | 0.0687 | 320.0 | -0.664 | 0.421 | 0.862 | 0.00261 | NA | 118.0 | 0.822 | 0.941 | 118.0 | 0.0 | 0.425 | 0.854 | 0.00309 | NA |
HCC1806 | MK2206 | 1 | 72 | sigmoid | sigmoid | HCC1806 MK-2206 0 1 72 | 8 | 2.746 | 47.7 | 0.818 | 0.0504 | 320.0 | -0.715 | 0.466 | 0.981 | 7.02e-06 | NA | Inf | 0.769 | 0.934 | 4.46 | 0.507 | 0.566 | 0.976 | 1.46e-05 | NA |
HCC1806 | PIK-93 | 3 | 72 | sigmoid | sigmoid | HCC1806 PIK-93 0 3 72 | 8 | 3.206 | 56.0 | 0.873 | 0.0337 | 320.0 | -0.872 | 0.579 | 0.859 | 0.00279 | NA | 46.6 | 0.811 | 0.948 | 46.6 | 0.0 | 0.57 | 0.84 | 0.00406 | NA |
HCC38 | MK2206 | 3 | 72 | sigmoid | sigmoid | HCC38 MK-2206 0 3 72 | 8 | 1.445 | 71.7 | 0.728 | 0.123 | 320.0 | -0.26 | 0.28 | 0.854 | 0.0031 | NA | Inf | 0.81 | 0.912 | 4.3 | 0.61 | 0.332 | 0.834 | 0.00461 | NA |
BT-20 | AS605240 | 2 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 2 72 | 8 | 1.846 | 4509270.0 | 0.729 | 0.203 | 320.0 | 0.31 | 0.101 | 0.845 | 0.00373 | NA | 4.4e+12 | 0.764 | 0.821 | 56.5 | 0.46 | 0.101 | 0.843 | 0.00388 | NA |
Hs 578T | CAL-101 | 2 | sigmoid | sigmoid | Hs578T idelalisib 2 | 8 | 2.534 | 57.5 | 0.801 | 0.0636 | 320.0 | -0.507 | 0.408 | 0.979 | 9.58e-06 | NA | Inf | 0.766 | 0.923 | 4.27 | 0.505 | 0.495 | 0.975 | 1.65e-05 | NA |