Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC38	WYE-125132	1	72	sigmoid	sigmoid	HCC38 WYE-132 0 1 72	8	1.708	0.0604	0.142	0.447	0.0481	0.134	1.36	0.997	3.43e-08	NA	0.115	0.384	0.669	0.0413	0.381	1.4	0.996	6.46e-08	NA
BT-549	AZD8055	3	72	sigmoid	sigmoid	BT549 AZD8055 0 3 72	8	1.757	0.0178	0.159	0.59	0.0122	0.145	0.913	0.942	0.000193	NA	0.0479	0.383	0.555	0.00973	0.372	0.854	0.954	9.74e-05	NA
BT-549	AZD8055	1	72	sigmoid	sigmoid	BT549 AZD8055 0 1 72	8	1.781	0.0305	0.165	0.526	0.0228	0.14	1.13	0.992	4.7e-07	NA	0.0615	0.382	0.599	0.0189	0.367	1.12	0.994	1.9e-07	NA
HCC38	Trametinib	2	72	sigmoid	sigmoid	HCC38 trametinib 0 2 72	8	2.133	0.219	0.267	0.389	0.222	-0.00324	0.424	0.987	2.39e-06	NA	0.391	0.377	0.644	0.127	0.183	0.404	0.988	1.91e-06	NA
HCC38	AZD8055	1	72	sigmoid	sigmoid	HCC38 AZD8055 0 1 72	8	1.773	0.052	0.151	0.479	0.0381	0.136	1.02	0.992	4.28e-07	NA	0.116	0.375	0.633	0.0313	0.363	0.987	0.993	3.89e-07	NA
Hs 578T	PIK-93	3		sigmoid	sigmoid	Hs578T PIK-93 3	8	2.816	2.36	0.412	0.0884	2.23	0.033	1.2	0.994	1.87e-07	NA	1.89	0.375	0.897	1.42	0.149	1.24	0.991	8.33e-07	NA
BT-20	PIK-93	2	72	sigmoid	sigmoid	BT20 PIK-93 0 2 72	8	1.798	0.792	0.155	0.286	14.1	-1.0	0.382	0.81	0.00687	NA	2.8	0.373	0.764	2.8	0.0	0.344	0.77	0.0121	NA
BT-549	ZSTK474	3	72	sigmoid	sigmoid	BT549 ZSTK474 0 3 72	8	1.776	0.504	0.139	0.267	0.616	-0.0912	0.836	0.996	7.06e-08	NA	0.994	0.368	0.789	0.489	0.218	0.808	0.995	9.19e-08	NA
HCC70	Dactolisib	3	72	sigmoid	sigmoid	HCC70 dactolisib 0 3 72	8	2.430	0.738	0.321	0.312	18.6	-0.818	0.3	0.975	1.64e-05	NA	0.688	0.365	0.675	0.635	0.0134	0.338	0.97	2.7e-05	NA
BT-20	AZD8055	1	72	sigmoid	sigmoid	BT20 AZD8055 0 1 72	8	2.117	0.0548	0.243	0.465	0.0266	0.213	0.768	0.984	4.08e-06	NA	0.0937	0.365	0.589	0.0198	0.335	0.713	0.982	5.4e-06	NA
HCC38	GDC-0980	3	72	sigmoid	sigmoid	HCC38 apitolisib 0 3 72	8	1.437	0.371	-0.0189	0.29	0.513	-0.179	0.946	0.993	3.35e-07	NA	0.96	0.359	0.808	0.393	0.295	0.998	0.993	3.51e-07	NA
HCC38	PI103	2	72	sigmoid	sigmoid	HCC38 PI-103 0 2 72	8	2.094	0.856	0.226	0.167	0.672	0.135	1.3	0.986	2.7e-06	NA	1.04	0.359	0.851	0.488	0.33	1.43	0.981	6.52e-06	NA
HCC70	Pictilisib	2	72	sigmoid	sigmoid	HCC70 pictilisib 0 2 72	8	1.783	0.811	0.124	0.189	0.858	-0.0372	1.27	0.973	2.08e-05	NA	1.25	0.358	0.852	0.678	0.278	1.32	0.963	5.09e-05	NA
HCC38	WYE-125132	3	72	sigmoid	sigmoid	HCC38 WYE-132 0 3 72	8	1.449	0.0494	-0.0216	0.518	0.0504	-0.0117	1.18	0.998	9.69e-09	NA	0.128	0.355	0.662	0.0441	0.361	1.2	0.998	9.53e-09	NA
BT-549	AZD8055	2	72	sigmoid	sigmoid	BT549 AZD8055 0 2 72	8	1.848	0.0373	0.14	0.506	0.0287	0.138	1.23	0.994	2.1e-07	NA	0.0653	0.354	0.605	0.0239	0.35	1.2	0.995	1.39e-07	NA
HCC38	GDC-0980	1	72	sigmoid	sigmoid	HCC38 apitolisib 0 1 72	8	1.777	0.317	0.114	0.305	0.295	0.0315	0.91	0.99	9.47e-07	NA	0.623	0.354	0.761	0.219	0.315	0.951	0.989	1.26e-06	NA
HCC70	MK2206	1	72	sigmoid	sigmoid	HCC70 MK-2206 0 1 72	8	1.444	0.314	-0.0266	0.337	0.618	-0.336	0.758	0.991	6.35e-07	NA	0.925	0.353	0.775	0.521	0.172	0.737	0.99	1.08e-06	NA
BT-549	GDC-0980	1	72	sigmoid	sigmoid	BT549 apitolisib 0 1 72	8	1.781	0.19	0.113	0.333	0.16	0.1	1.27	0.999	4.05e-10	NA	0.328	0.352	0.744	0.132	0.347	1.31	0.999	7.05e-10	NA
HCC70	Pictilisib	3	72	sigmoid	sigmoid	HCC70 pictilisib 0 3 72	8	2.450	1.32	0.305	0.102	0.938	0.225	1.76	0.983	4.73e-06	NA	1.28	0.351	0.901	0.766	0.303	1.81	0.973	2.06e-05	NA
BT-549	WYE-125132	1	72	sigmoid	sigmoid	BT549 WYE-132 0 1 72	8	1.787	0.0317	0.11	0.542	0.026	0.0962	1.09	0.996	5.11e-08	NA	0.062	0.349	0.589	0.0213	0.338	1.05	0.997	3.82e-08	NA
BT-20	MK2206	2	72	sigmoid	sigmoid	BT20 MK-2206 0 2 72	8	1.739	0.823	0.0896	0.246	4.34	-1.0	0.661	0.965	4.36e-05	NA	1.47	0.348	0.806	1.47	0.0	0.715	0.947	0.000145	NA
HCC70	Dactolisib	1	72	sigmoid	sigmoid	HCC70 dactolisib 0 1 72	8	1.400	0.0808	-0.0667	0.501	3.34	-1.0	0.295	0.963	5.02e-05	NA	0.753	0.344	0.673	0.753	0.0	0.308	0.962	5.37e-05	NA
BT-20	AZD8055	3	72	sigmoid	sigmoid	BT20 AZD8055 0 3 72	8	2.694	0.0351	0.345	0.472	0.0116	0.313	0.89	0.934	0.000286	NA	0.0291	0.343	0.506	0.00813	0.306	0.743	0.922	0.000471	NA
BT-20	AZD8055	2	72	sigmoid	sigmoid	BT20 AZD8055 0 2 72	8	1.951	0.00909	0.155	0.651	0.00651	0.115	0.785	0.936	0.000258	NA	0.0185	0.343	0.477	0.00469	0.311	0.706	0.934	0.000289	NA
BT-20	AZD-6482	1	72	sigmoid	sigmoid	BT20 AZD6482 0 1 72	8	2.043	1.34	0.182	0.173	3.83	-0.782	0.893	0.982	5.6e-06	NA	1.65	0.342	0.845	1.65	0.0	0.977	0.972	2.09e-05	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)