Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC70 | Pictilisib | 2 | 72 | sigmoid | sigmoid | HCC70 pictilisib 0 2 72 | 8 | 1.783 | 0.811 | 0.124 | 0.189 | 0.858 | -0.0372 | 1.27 | 0.973 | 2.08e-05 | NA | 1.25 | 0.358 | 0.852 | 0.678 | 0.278 | 1.32 | 0.963 | 5.09e-05 | NA |
HCC38 | Dactolisib | 3 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 3 72 | 8 | 1.468 | 0.0082 | -0.197 | 0.778 | 0.0127 | -0.181 | 0.711 | 0.993 | 3.98e-07 | NA | 0.0268 | 0.262 | 0.497 | 0.00923 | 0.277 | 0.757 | 0.994 | 2.62e-07 | NA |
Hs 578T | WYE-125132 | 1 | sigmoid | sigmoid | Hs578T WYE-132 1 | 8 | 2.015 | 0.0322 | 0.0601 | 0.551 | 0.0286 | 0.0544 | 0.962 | 0.998 | 4.17e-09 | NA | 0.0469 | 0.278 | 0.55 | 0.0207 | 0.275 | 0.978 | 0.999 | 2.33e-09 | NA | |
HCC70 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | HCC70 ZSTK474 0 3 72 | 8 | 2.502 | 0.455 | 0.176 | 0.223 | 0.345 | 0.155 | 1.35 | 0.991 | 8.07e-07 | NA | 0.401 | 0.265 | 0.782 | 0.24 | 0.274 | 1.55 | 0.987 | 1.99e-06 | NA |
Hs 578T | AZD8055 | 1 | sigmoid | sigmoid | Hs578T AZD8055 1 | 8 | 2.009 | 0.0391 | 0.073 | 0.531 | 0.0347 | 0.0546 | 0.975 | 0.995 | 1.39e-07 | NA | 0.0591 | 0.286 | 0.565 | 0.0259 | 0.27 | 0.941 | 0.994 | 1.73e-07 | NA | |
HCC38 | Torin1 | 2 | 72 | sigmoid | sigmoid | HCC38 Torin1 0 2 72 | 8 | 2.136 | 0.0241 | 0.0393 | 0.573 | 0.0203 | 0.0651 | 0.82 | 0.995 | 1.24e-07 | NA | 0.0309 | 0.247 | 0.512 | 0.013 | 0.267 | 0.88 | 0.996 | 4.87e-08 | NA |
HCC70 | GDC-0980 | 3 | 72 | sigmoid | sigmoid | HCC70 apitolisib 0 3 72 | 8 | 2.423 | 0.623 | 0.206 | 0.211 | 0.509 | 0.0878 | 0.959 | 0.986 | 2.55e-06 | NA | 0.568 | 0.293 | 0.792 | 0.283 | 0.266 | 1.09 | 0.981 | 6.41e-06 | NA |
HCC70 | BX-912 | 3 | 72 | sigmoid | sigmoid | HCC70 BX-912 0 3 72 | 8 | 2.465 | 1.26 | 0.174 | 0.0739 | 1.16 | 0.168 | 5.0 | 0.988 | 1.75e-06 | NA | 1.26 | 0.269 | 0.935 | 1.08 | 0.265 | 5.0 | 0.977 | 1.15e-05 | NA |
HCC70 | Pictilisib | 1 | 72 | sigmoid | sigmoid | HCC70 pictilisib 0 1 72 | 8 | 1.409 | 0.408 | -0.099 | 0.284 | 0.578 | -0.245 | 1.14 | 0.996 | 7.62e-08 | NA | 0.888 | 0.325 | 0.816 | 0.477 | 0.261 | 1.19 | 0.995 | 1.2e-07 | NA |
BT-549 | PI103 | 2 | 72 | sigmoid | sigmoid | BT549 PI-103 0 2 72 | 8 | 1.893 | 0.218 | 0.0201 | 0.344 | 0.229 | -0.0262 | 1.08 | 0.997 | 2.55e-08 | NA | 0.326 | 0.28 | 0.725 | 0.169 | 0.261 | 1.13 | 0.996 | 6.2e-08 | NA |
BT-549 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | BT549 ZSTK474 0 1 72 | 8 | 1.861 | 0.58 | 0.213 | 0.256 | 0.583 | -0.00205 | 0.771 | 0.992 | 5.43e-07 | NA | 1.12 | 0.394 | 0.788 | 0.428 | 0.261 | 0.767 | 0.989 | 1.49e-06 | NA |
HCC1806 | Torin1 | 1 | 72 | sigmoid | sigmoid | HCC1806 Torin1 0 1 72 | 8 | 2.755 | 0.303 | 0.246 | 0.317 | 0.152 | 0.185 | 0.669 | 0.988 | 1.74e-06 | NA | 0.186 | 0.272 | 0.651 | 0.0697 | 0.26 | 0.75 | 0.992 | 4.55e-07 | NA |
HCC1806 | Torin1 | 2 | 72 | sigmoid | sigmoid | HCC1806 Torin1 0 2 72 | 8 | 2.840 | 0.336 | 0.264 | 0.309 | 0.154 | 0.203 | 0.668 | 0.988 | 1.77e-06 | NA | 0.186 | 0.272 | 0.651 | 0.0697 | 0.26 | 0.75 | 0.992 | 4.55e-07 | NA |
HCC1806 | Torin1 | 3 | 72 | sigmoid | sigmoid | HCC1806 Torin1 0 3 72 | 8 | 3.208 | 0.537 | 0.332 | 0.278 | 0.165 | 0.271 | 0.662 | 0.988 | 1.91e-06 | NA | 0.186 | 0.272 | 0.651 | 0.0697 | 0.26 | 0.75 | 0.992 | 4.55e-07 | NA |
Hs 578T | Dactolisib | 1 | sigmoid | sigmoid | Hs578T dactolisib 1 | 8 | 2.047 | 0.00952 | -0.0606 | 0.691 | 0.00928 | 0.0117 | 0.91 | 0.977 | 1.27e-05 | NA | 0.0124 | 0.213 | 0.443 | 0.00621 | 0.259 | 1.06 | 0.985 | 3.61e-06 | NA | |
BT-549 | GDC-0980 | 2 | 72 | sigmoid | sigmoid | BT549 apitolisib 0 2 72 | 8 | 1.939 | 0.189 | 0.0264 | 0.357 | 0.193 | -0.011 | 1.04 | 0.997 | 2.98e-08 | NA | 0.278 | 0.274 | 0.71 | 0.142 | 0.257 | 1.07 | 0.997 | 3.64e-08 | NA |
BT-20 | WYE-125132 | 2 | 72 | sigmoid | sigmoid | BT20 WYE-132 0 2 72 | 8 | 2.053 | 0.012 | 0.142 | 0.633 | 0.00936 | 0.072 | 0.621 | 0.909 | 0.000752 | NA | 0.0232 | 0.316 | 0.475 | 0.00613 | 0.255 | 0.536 | 0.894 | 0.00119 | NA |
BT-549 | Trametinib | 1 | 72 | sigmoid | sigmoid | BT549 trametinib 0 1 72 | 8 | 1.812 | Inf | 0.596 | 0.202 | 0.131 | 0.523 | 0.61 | 0.959 | 6.65e-05 | NA | 28.3 | 0.664 | 0.828 | 3.47 | 0.254 | 0.337 | 0.933 | 0.000305 | NA |
HCC70 | GDC-0980 | 2 | 72 | sigmoid | sigmoid | HCC70 apitolisib 0 2 72 | 8 | 1.676 | 0.318 | -0.0849 | 0.284 | 0.451 | -0.205 | 0.983 | 0.976 | 1.34e-05 | NA | 0.536 | 0.27 | 0.795 | 0.285 | 0.252 | 1.11 | 0.972 | 2.28e-05 | NA |
BT-20 | PI103 | 1 | 72 | sigmoid | sigmoid | BT20 PI-103 0 1 72 | 8 | 1.924 | 0.646 | -0.0114 | 0.16 | 0.659 | -0.0268 | 2.6 | 0.978 | 1.1e-05 | NA | 0.753 | 0.258 | 0.883 | 0.579 | 0.252 | 2.68 | 0.964 | 4.79e-05 | NA |
BT-20 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | BT20 ZSTK474 0 1 72 | 8 | 1.940 | 0.788 | 0.0217 | 0.122 | 0.819 | -0.0395 | 1.99 | 0.957 | 7.76e-05 | NA | 0.942 | 0.272 | 0.913 | 0.677 | 0.249 | 2.09 | 0.934 | 0.000293 | NA |
Hs 578T | AZD8055 | 2 | sigmoid | sigmoid | Hs578T AZD8055 2 | 8 | 2.480 | 0.0521 | 0.149 | 0.469 | 0.0387 | 0.142 | 1.13 | 0.999 | 3.49e-10 | NA | 0.0495 | 0.253 | 0.557 | 0.0273 | 0.249 | 1.16 | 0.999 | 4.45e-10 | NA | |
BT-20 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | BT20 WYE-132 0 3 72 | 8 | 2.654 | 0.0504 | 0.282 | 0.465 | 0.0254 | 0.236 | 0.929 | 0.922 | 0.000468 | NA | 0.048 | 0.307 | 0.526 | 0.0182 | 0.246 | 0.698 | 0.918 | 0.000553 | NA |
HCC38 | Dactolisib | 2 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 2 72 | 8 | 2.120 | 0.0118 | -0.0557 | 0.668 | 0.0118 | -0.00134 | 0.785 | 0.98 | 7.61e-06 | NA | 0.0145 | 0.204 | 0.447 | 0.00701 | 0.245 | 0.927 | 0.988 | 1.88e-06 | NA |
HCC38 | Torin1 | 3 | 72 | sigmoid | sigmoid | HCC38 Torin1 0 3 72 | 8 | 1.441 | 0.0231 | -0.202 | 0.666 | 0.0412 | -0.248 | 0.698 | 0.999 | 5.79e-10 | NA | 0.0787 | 0.266 | 0.572 | 0.0306 | 0.245 | 0.714 | 0.999 | 5.55e-10 | NA |