Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-549	CAL-101	2	72	sigmoid	sigmoid	BT549 idelalisib 0 2 72	8	1.975	Inf	0.792	0.0561	4.65	0.526	0.693	0.933	0.000307	NA	43.0	0.805	0.946	43.0	0.0	0.548	0.932	0.000314	NA
HCC38	MK2206	3	72	sigmoid	sigmoid	HCC38 MK-2206 0 3 72	8	1.445	71.7	0.728	0.123	320.0	-0.26	0.28	0.854	0.0031	NA	Inf	0.81	0.912	4.3	0.61	0.332	0.834	0.00461	NA
HCC38	CAL-101	3	72	sigmoid	sigmoid	HCC38 idelalisib 0 3 72	8	1.443	Inf	0.851	0.0804	4.08	0.726	0.225	0.706	0.0254	NA	Inf	0.894	0.943	4.27	0.804	0.222	0.707	0.0252	NA
Hs 578T	CAL-101	2		sigmoid	sigmoid	Hs578T idelalisib 2	8	2.534	57.5	0.801	0.0636	320.0	-0.507	0.408	0.979	9.58e-06	NA	Inf	0.766	0.923	4.27	0.505	0.495	0.975	1.65e-05	NA
BT-549	Alpelisib	2	72	sigmoid	sigmoid	BT549 alpelisib 0 2 72	8	1.927	Inf	0.832	0.0409	4.24	0.663	0.548	0.706	0.0254	NA	Inf	0.844	0.962	4.26	0.686	0.542	0.696	0.0282	NA
BT-549	AZD-6482	1	72	sigmoid	sigmoid	BT549 AZD6482 0 1 72	8	1.798	27.5	0.671	0.115	4.1	0.299	0.478	0.992	4.23e-07	NA	164.0	0.723	0.901	4.18	0.408	0.461	0.992	5.34e-07	NA
BT-20	MK2206	1	72	sigmoid	sigmoid	BT20 MK-2206 0 1 72	8	2.089	Inf	0.732	0.102	4.16	0.529	0.345	0.671	0.0357	NA	Inf	0.741	0.898	4.14	0.538	0.337	0.676	0.034	NA
BT-20	AS605240	3	72	sigmoid	sigmoid	BT20 AS-605240 0 3 72	8	2.607	Inf	0.845	0.0823	4.13	0.662	0.292	0.729	0.0199	NA	Inf	0.81	0.897	3.97	0.589	0.284	0.712	0.0239	NA
Hs 578T	Alpelisib	1		sigmoid	sigmoid	Hs578T alpelisib 1	8	2.097	2.3	0.449	0.205	42.0	-1.0	0.378	0.954	9.56e-05	NA	3.9	0.508	0.803	3.9	0.0	0.401	0.94	0.000216	NA
BT-20	AS605240	1	72	sigmoid	sigmoid	BT20 AS-605240 0 1 72	8	2.142	Inf	0.817	0.0993	3.91	0.634	0.244	0.861	0.00271	NA	Inf	0.814	0.897	3.87	0.629	0.237	0.854	0.00311	NA
BT-549	Trametinib	1	72	sigmoid	sigmoid	BT549 trametinib 0 1 72	8	1.812	Inf	0.596	0.202	0.131	0.523	0.61	0.959	6.65e-05	NA	28.3	0.664	0.828	3.47	0.254	0.337	0.933	0.000305	NA
HCC70	TGX221	2	72	sigmoid	sigmoid	HCC70 TGX-221 0 2 72	8	1.786	1.77	0.467	0.233	0.531	0.227	0.503	0.948	0.000139	NA	5.85	0.575	0.806	3.44	0.0897	0.372	0.937	0.000249	NA
HCC70	PIK-93	3	72	sigmoid	sigmoid	HCC70 PIK-93 0 3 72	8	2.519	21.2	0.756	0.0663	181.0	-1.0	0.513	0.851	0.00333	NA	34.1	0.721	0.92	34.1	0.0	0.473	0.831	0.00487	NA
HCC38	ZSTK474	3	72	sigmoid	sigmoid	HCC38 ZSTK474 0 3 72	8	1.458	2.06	0.398	0.146	5.06	-0.41	0.665	0.989	1.23e-06	NA	6.44	0.593	0.898	3.35	0.179	0.678	0.988	1.64e-06	NA
BT-549	TGX221	2	72	sigmoid	sigmoid	BT549 TGX-221 0 2 72	8	1.927	17.5	0.772	0.0551	123.0	-1.0	0.562	0.907	0.000795	NA	32.3	0.792	0.949	32.3	3.45e-05	0.58	0.899	0.00102	NA
HCC38	TGX221	3	72	sigmoid	sigmoid	HCC38 TGX-221 0 3 72	8	1.484	3688.0	0.815	0.0743	320.0	0.243	0.273	0.867	0.00233	NA	3261706.0	0.866	0.945	320.0	0.458	0.269	0.867	0.00238	NA
BT-549	TGX221	3	72	sigmoid	sigmoid	BT549 TGX-221 0 3 72	8	1.768	93790.0	0.805	0.0889	320.0	0.356	0.22	0.707	0.0251	NA	49050766.0	0.834	0.923	320.0	0.461	0.214	0.703	0.0263	NA
Hs 578T	AZD-6482	1		sigmoid	sigmoid	Hs578T AZD6482 1	8	2.041	2.04	0.401	0.177	18.5	-1.0	0.498	0.986	2.92e-06	NA	3.16	0.484	0.835	3.16	0.0	0.532	0.98	7.93e-06	NA
Hs 578T	KIN001-244	1		sigmoid	sigmoid	Hs578T KIN001-244 1	8	2.041	24.7	0.739	0.0391	4.05	0.414	0.972	0.968	3.4e-05	NA	Inf	0.752	0.962	3.15	0.51	0.99	0.964	4.65e-05	NA
BT-20	PIK-93	1	72	sigmoid	sigmoid	BT20 PIK-93 0 1 72	8	2.025	2.65	0.406	0.0864	6.54	-1.0	1.22	0.993	3.89e-07	NA	3.15	0.49	0.92	3.15	0.0	1.31	0.989	1.33e-06	NA
BT-549	Pictilisib	2	72	sigmoid	sigmoid	BT549 pictilisib 0 2 72	8	1.960	1.84	0.365	0.166	11.5	-1.0	0.599	0.943	0.000187	NA	2.82	0.473	0.851	2.82	0.0	0.647	0.924	0.000432	NA
BT-20	PIK-93	2	72	sigmoid	sigmoid	BT20 PIK-93 0 2 72	8	1.798	0.792	0.155	0.286	14.1	-1.0	0.382	0.81	0.00687	NA	2.8	0.373	0.764	2.8	0.0	0.344	0.77	0.0121	NA
BT-549	KIN001-244	2	72	sigmoid	sigmoid	BT549 KIN001-244 0 2 72	8	1.920	Inf	0.882	0.00561	2.72	0.793	1.67	0.73	0.0197	NA	Inf	0.89	0.995	2.6	0.813	1.68	0.718	0.0225	NA
BT-20	Trametinib	2	72	sigmoid	sigmoid	BT20 trametinib 0 2 72	8	1.723	0.761	0.303	0.289	11.1	-0.768	0.347	0.965	4.13e-05	NA	2.56	0.478	0.77	2.56	0.0	0.362	0.957	8.16e-05	NA
BT-20	PIK-93	3	72	sigmoid	sigmoid	BT20 PIK-93 0 3 72	8	2.532	2.65	0.419	0.097	7.54	-1.0	1.05	0.982	5.47e-06	NA	2.5	0.42	0.892	2.5	0.0	1.17	0.971	2.45e-05	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)