Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T MK2206 2
sigmoid
sigmoid
Hs578T MK-2206 2
 8 2.530
Inf
0.664
0.131
0.0699
0.752
1.34
0.75
0.0156
NA
Inf
0.628
0.848
0.0616
0.717
1.21
0.767
0.0126
NA
Hs 578T MK2206 3
sigmoid
sigmoid
Hs578T MK-2206 3
 8 2.883
Inf
0.737
0.0965
0.144
0.768
1.94
0.962
5.58e-05
NA
Inf
0.666
0.873
0.135
0.7
1.85
0.967
3.69e-05
NA
Hs 578T PI103 1
sigmoid
sigmoid
Hs578T PI-103 1
 8 2.062
0.131
-0.0743
0.433
0.182
-0.173
0.898
0.996
4.43e-08
NA
0.175
0.204
0.643
0.117
0.152
0.898
0.995
1.02e-07
NA
Hs 578T PI103 2
sigmoid
sigmoid
Hs578T PI-103 2
 8 2.503
0.223
-0.0213
0.356
0.303
-0.15
0.858
0.999
7.33e-10
NA
0.206
0.167
0.661
0.152
0.121
0.921
0.999
1.9e-09
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA
Hs 578T PIK-93 1
sigmoid
sigmoid
Hs578T PIK-93 1
 8 2.033
1.44
0.276
0.175
8.38
-1.0
0.624
0.991
6.57e-07
NA
2.0
0.401
0.84
2.0
0.0
0.672
0.99
9.72e-07
NA
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
Hs 578T PIK-93 3
sigmoid
sigmoid
Hs578T PIK-93 3
 8 2.816
2.36
0.412
0.0884
2.23
0.033
1.2
0.994
1.87e-07
NA
1.89
0.375
0.897
1.42
0.149
1.24
0.991
8.33e-07
NA
Hs 578T Sirolimus 1
sigmoid
sigmoid
Hs578T rapamycin 1
 8 2.013
110643.0
0.587
0.358
0.000237
0.432
0.1
0.879
0.00178
NA
9.61e+11
0.628
0.672
0.000175
0.487
0.1
0.851
0.00332
NA
Hs 578T Sirolimus 2
flat
flat
Hs578T rapamycin 2
 8 2.536
Inf
0.623
0.341
0.0
0.623
0.01
0.16
0.593
0.66
Inf
0.589
0.623
0.0
0.589
0.01
-0.232
1.0
0.624
Hs 578T Sirolimus 3
flat
flat
Hs578T rapamycin 3
 8 2.836
Inf
0.675
0.309
0.0
0.675
0.01
-1.79
1.0
0.691
Inf
0.604
0.621
0.0
0.604
0.01
-3.02
1.0
0.621
Hs 578T TGX221 1
sigmoid
sigmoid
Hs578T TGX-221 1
 8 2.019
14.6
0.686
0.0936
23.9
-0.133
0.479
0.995
1.07e-07
NA
27.2
0.708
0.91
11.5
0.171
0.484
0.995
1.48e-07
NA
Hs 578T TGX221 2
sigmoid
sigmoid
Hs578T TGX-221 2
 8 2.462
Inf
0.816
0.0307
0.904
0.781
1.29
0.964
4.56e-05
NA
Inf
0.789
0.964
0.834
0.754
1.3
0.96
6.63e-05
NA
Hs 578T TGX221 3
sigmoid
sigmoid
Hs578T TGX-221 3
 8 2.818
24.2
0.885
0.0148
88.9
-1.0
0.843
0.958
7.66e-05
NA
23.4
0.846
0.98
23.4
0.0
0.862
0.953
0.000103
NA
Hs 578T Torin1 1
sigmoid
sigmoid
Hs578T Torin1 1
 8 1.956
0.0217
0.0183
0.598
0.0203
0.0286
0.911
0.994
1.81e-07
NA
0.0321
0.267
0.524
0.0141
0.28
0.995
0.996
8.78e-08
NA
Hs 578T Torin1 2
sigmoid
sigmoid
Hs578T Torin1 2
 8 2.548
0.0205
0.144
0.566
0.0148
0.14
1.0
0.999
3.13e-10
NA
0.0182
0.241
0.463
0.00975
0.24
1.04
0.999
6.11e-10
NA
Hs 578T Torin1 3
sigmoid
sigmoid
Hs578T Torin1 3
 8 2.860
0.0307
0.174
0.514
0.0196
0.176
0.964
0.999
2.01e-09
NA
0.0212
0.218
0.469
0.0119
0.222
1.02
0.998
1.17e-08
NA
Hs 578T Torin2 1
sigmoid
sigmoid
Hs578T Torin2 1
 8 2.031
0.015
-0.405
0.761
0.0631
-0.56
0.522
0.992
5.31e-07
NA
0.021
0.0851
0.419
0.0163
0.0756
0.64
0.993
3.63e-07
NA
Hs 578T Torin2 2
sigmoid
sigmoid
Hs578T Torin2 2
 8 2.528
0.0153
-0.467
0.778
0.112
-0.771
0.47
0.986
2.55e-06
NA
0.0122
0.0353
0.352
0.0109
0.036
0.668
0.984
4.09e-06
NA
Hs 578T Torin2 3
sigmoid
sigmoid
Hs578T Torin2 3
 8 2.844
0.0272
-0.327
0.667
0.144
-0.614
0.48
0.994
2.62e-07
NA
0.0164
0.0451
0.381
0.0148
0.0308
0.638
0.995
1.07e-07
NA
Hs 578T Trametinib 1
sigmoid
sigmoid
Hs578T trametinib 1
 8 2.044
0.00353
-0.00904
0.765
0.00516
-0.0906
0.437
0.992
4.85e-07
NA
0.00661
0.238
0.385
0.00213
0.201
0.456
0.993
3e-07
NA
Hs 578T Trametinib 2
sigmoid
sigmoid
Hs578T trametinib 2
 8 2.483
0.00633
0.074
0.701
0.00558
0.0362
0.593
0.998
1.32e-08
NA
0.0058
0.214
0.361
0.00257
0.193
0.602
0.998
3.66e-09
NA
Hs 578T Trametinib 3
sigmoid
sigmoid
Hs578T trametinib 3
 8 2.830
0.0128
0.0657
0.644
0.0112
0.0447
0.702
0.998
4.02e-09
NA
0.00864
0.168
0.366
0.00512
0.157
0.722
0.998
5.57e-09
NA
Hs 578T WYE-125132 1
sigmoid
sigmoid
Hs578T WYE-132 1
 8 2.015
0.0322
0.0601
0.551
0.0286
0.0544
0.962
0.998
4.17e-09
NA
0.0469
0.278
0.55
0.0207
0.275
0.978
0.999
2.33e-09
NA
Hs 578T WYE-125132 2
sigmoid
sigmoid
Hs578T WYE-132 2
 8 2.544
0.0374
0.152
0.505
0.0268
0.147
1.04
0.999
8.81e-10
NA
0.0344
0.246
0.516
0.0183
0.239
1.03
0.999
2.53e-09
NA