Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T PI103 2
sigmoid
sigmoid
Hs578T PI-103 2
 8 2.503
0.223
-0.0213
0.356
0.303
-0.15
0.858
0.999
7.33e-10
NA
0.206
0.167
0.661
0.152
0.121
0.921
0.999
1.9e-09
NA
BT-549 Torin2 2 72
sigmoid
sigmoid
BT549 Torin2 0 2 72
 8 1.824
0.00997
-0.281
0.767
0.0212
-0.282
0.594
0.975
1.47e-05
NA
0.0177
0.155
0.438
0.00929
0.188
0.734
0.973
2.02e-05
NA
HCC70 Torin2 3 72
sigmoid
sigmoid
HCC70 Torin2 0 3 72
 8 2.425
0.076
-0.384
0.567
0.532
-0.933
0.541
0.988
1.88e-06
NA
0.0694
0.0576
0.51
0.0694
0.0
0.61
0.973
2.02e-05
NA
HCC70 Torin1 1 72
sigmoid
sigmoid
HCC70 Torin1 0 1 72
 8 1.345
0.0472
0.15
0.487
0.0311
0.149
0.849
0.973
1.89e-05
NA
0.93
0.475
0.693
0.0276
0.475
0.854
0.973
2.05e-05
NA
HCC70 Pictilisib 3 72
sigmoid
sigmoid
HCC70 pictilisib 0 3 72
 8 2.450
1.32
0.305
0.102
0.938
0.225
1.76
0.983
4.73e-06
NA
1.28
0.351
0.901
0.766
0.303
1.81
0.973
2.06e-05
NA
BT-20 Dactolisib 2 72
sigmoid
sigmoid
BT20 dactolisib 0 2 72
 8 1.727
0.00497
-0.212
0.896
0.00652
-0.186
1.17
0.995
1.45e-07
NA
0.00801
0.2
0.382
0.00505
0.211
1.19
0.994
2.07e-07
NA
BT-20 AZD-6482 1 72
sigmoid
sigmoid
BT20 AZD6482 0 1 72
 8 2.043
1.34
0.182
0.173
3.83
-0.782
0.893
0.982
5.6e-06
NA
1.65
0.342
0.845
1.65
0.0
0.977
0.972
2.09e-05
NA
HCC38 GDC-0980 2 72
sigmoid
sigmoid
HCC38 apitolisib 0 2 72
 8 2.159
0.33
0.153
0.279
0.253
0.117
1.0
0.992
4.91e-07
NA
0.385
0.304
0.749
0.165
0.308
1.13
0.994
2.09e-07
NA
BT-549 Pictilisib 3 72
sigmoid
sigmoid
BT549 pictilisib 0 3 72
 8 1.767
1.42
0.276
0.169
4.62
-0.67
0.722
0.998
9.61e-09
NA
2.47
0.452
0.863
2.47
0.0
0.742
0.997
2.13e-08
NA
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
HCC70 Torin1 3 72
sigmoid
sigmoid
HCC70 Torin1 0 3 72
 8 2.415
3.74
0.495
0.279
0.0352
0.496
1.02
0.994
2.6e-07
NA
5.73
0.495
0.709
0.0284
0.498
1.06
0.994
2.26e-07
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
Hs 578T WYE-125132 1
sigmoid
sigmoid
Hs578T WYE-132 1
 8 2.015
0.0322
0.0601
0.551
0.0286
0.0544
0.962
0.998
4.17e-09
NA
0.0469
0.278
0.55
0.0207
0.275
0.978
0.999
2.33e-09
NA
HCC70 ZSTK474 1 72
sigmoid
sigmoid
HCC70 ZSTK474 0 1 72
 8 1.332
0.167
-0.265
0.366
0.201
-0.206
1.85
0.975
1.56e-05
NA
0.289
0.264
0.782
0.182
0.299
1.96
0.971
2.35e-05
NA
BT-549 Dactolisib 1 72
sigmoid
sigmoid
BT549 dactolisib 0 1 72
 8 1.840
0.00961
-0.00769
0.683
0.00888
0.0384
1.01
0.985
3.53e-06
NA
0.0161
0.275
0.482
0.0068
0.303
1.09
0.987
2.38e-06
NA
BT-20 PIK-93 3 72
sigmoid
sigmoid
BT20 PIK-93 0 3 72
 8 2.532
2.65
0.419
0.097
7.54
-1.0
1.05
0.982
5.47e-06
NA
2.5
0.42
0.892
2.5
0.0
1.17
0.971
2.45e-05
NA
BT-549 Buparlisib 1 72
sigmoid
sigmoid
BT549 buparlisib 0 1 72
 8 1.837
0.729
-0.325
0.253
1.83
-1.0
1.19
0.994
2.4e-07
NA
0.926
0.136
0.807
0.926
0.0
1.37
0.987
2.46e-06
NA
HCC38 Buparlisib 3 72
sigmoid
sigmoid
HCC38 buparlisib 0 3 72
 8 1.431
0.674
-0.377
0.272
1.67
-1.0
1.21
0.991
6.94e-07
NA
1.11
0.188
0.824
1.11
0.0
1.32
0.987
2.46e-06
NA
HCC1806 Dactolisib 2 72
sigmoid
sigmoid
HCC1806 dactolisib 0 2 72
 8 2.828
0.145
-0.0528
0.433
0.401
-0.401
0.578
0.986
2.83e-06
NA
0.0977
0.121
0.559
0.0929
0.0151
0.619
0.986
2.47e-06
NA
HCC1806 Dactolisib 1 72
sigmoid
sigmoid
HCC1806 dactolisib 0 1 72
 8 2.743
0.135
-0.0744
0.444
0.391
-0.425
0.577
0.986
2.81e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
HCC1806 Dactolisib 3 72
sigmoid
sigmoid
HCC1806 dactolisib 0 3 72
 8 3.196
0.193
0.0324
0.393
0.437
-0.302
0.579
0.986
2.91e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
Hs 578T Buparlisib 2
sigmoid
sigmoid
Hs578T buparlisib 2
 8 2.513
0.665
-0.42
0.251
1.61
-1.0
1.24
0.998
1.14e-08
NA
0.595
0.0445
0.779
0.595
0.0
1.36
0.994
2.48e-07
NA
BT-549 BX-912 2 72
sigmoid
sigmoid
BT549 BX-912 0 2 72
 8 1.948
1.04
0.33
0.126
0.84
0.329
5.0
0.99
1.01e-06
NA
1.28
0.452
0.892
0.808
0.451
5.0
0.987
2.4e-06
NA
BT-20 Torin1 3 72
sigmoid
sigmoid
BT20 Torin1 0 3 72
 8 2.569
0.0237
0.0343
0.572
0.0199
0.0736
0.899
0.993
2.77e-07
NA
0.0208
0.184
0.46
0.0119
0.204
0.944
0.997
2.51e-08
NA