Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T CAL-101 2
sigmoid
sigmoid
Hs578T idelalisib 2
 8 2.534
57.5
0.801
0.0636
320.0
-0.507
0.408
0.979
9.58e-06
NA
Inf
0.766
0.923
4.27
0.505
0.495
0.975
1.65e-05
NA
HCC38 Dactolisib 1 72
sigmoid
sigmoid
HCC38 dactolisib 0 1 72
 8 1.821
0.0109
-0.0403
0.672
0.0104
0.0212
0.892
0.985
3.44e-06
NA
0.0194
0.263
0.492
0.00757
0.301
0.975
0.988
1.65e-06
NA
BT-549 Torin1 3 72
sigmoid
sigmoid
BT549 Torin1 0 3 72
 8 1.757
0.0123
0.026
0.659
0.0112
0.0466
1.02
0.997
3.77e-08
NA
0.0235
0.309
0.513
0.00878
0.322
1.05
0.997
1.65e-08
NA
HCC70 AZD8055 3 72
sigmoid
sigmoid
HCC70 AZD8055 0 3 72
 8 2.442
Inf
0.571
0.287
0.0133
0.574
1.17
0.98
8.55e-06
NA
Inf
0.554
0.694
0.0116
0.556
1.17
0.974
1.69e-05
NA
BT-20 PI103 3 72
sigmoid
sigmoid
BT20 PI-103 0 3 72
 8 2.496
0.373
0.0139
0.282
0.387
-0.0286
1.52
0.994
1.99e-07
NA
0.359
0.183
0.735
0.279
0.162
1.56
0.988
1.71e-06
NA
Hs 578T AZD8055 1
sigmoid
sigmoid
Hs578T AZD8055 1
 8 2.009
0.0391
0.073
0.531
0.0347
0.0546
0.975
0.995
1.39e-07
NA
0.0591
0.286
0.565
0.0259
0.27
0.941
0.994
1.73e-07
NA
Hs 578T Pictilisib 2
sigmoid
sigmoid
Hs578T pictilisib 2
 8 2.512
1.93
0.45
0.194
0.4
0.333
0.696
0.98
8e-06
NA
1.58
0.446
0.787
0.231
0.381
0.746
0.974
1.74e-05
NA
BT-20 Torin2 2 72
sigmoid
sigmoid
BT20 Torin2 0 2 72
 8 1.733
0.00315
-0.761
0.992
0.0484
-0.95
0.389
0.949
0.000131
NA
0.00804
0.0252
0.336
0.00642
0.0613
0.583
0.974
1.77e-05
NA
HCC38 Pictilisib 3 72
sigmoid
sigmoid
HCC38 pictilisib 0 3 72
 8 1.420
3.12
0.499
0.129
2.45
0.0818
0.738
0.976
1.33e-05
NA
20.5
0.664
0.911
2.24
0.401
0.731
0.974
1.7e-05
NA
HCC38 Torin2 1 72
sigmoid
sigmoid
HCC38 Torin2 0 1 72
 8 1.778
0.0133
-0.318
0.753
0.0337
-0.369
0.594
0.994
1.98e-07
NA
0.0264
0.148
0.459
0.0158
0.145
0.664
0.994
1.7e-07
NA
HCC70 AZD8055 1 72
sigmoid
sigmoid
HCC70 AZD8055 0 1 72
 8 1.339
0.0485
0.242
0.442
0.0243
0.26
1.06
0.976
1.32e-05
NA
Inf
0.529
0.721
0.0222
0.54
1.08
0.974
1.81e-05
NA
BT-549 PIK-93 1 72
sigmoid
sigmoid
BT549 PIK-93 0 1 72
 8 1.777
Inf
0.691
0.0438
1.77
0.561
1.47
0.989
1.31e-06
NA
Inf
0.742
0.963
1.64
0.646
1.47
0.988
1.83e-06
NA
BT-20 ZSTK474 2 72
sigmoid
sigmoid
BT20 ZSTK474 0 2 72
 8 1.787
0.286
-0.19
0.347
0.373
-0.234
1.46
0.992
4.53e-07
NA
0.391
0.199
0.743
0.29
0.184
1.55
0.988
1.84e-06
NA
HCC38 Dactolisib 2 72
sigmoid
sigmoid
HCC38 dactolisib 0 2 72
 8 2.120
0.0118
-0.0557
0.668
0.0118
-0.00134
0.785
0.98
7.61e-06
NA
0.0145
0.204
0.447
0.00701
0.245
0.927
0.988
1.88e-06
NA
BT-549 Torin2 1 72
sigmoid
sigmoid
BT549 Torin2 0 1 72
 8 1.771
0.0095
-0.218
0.756
0.0155
-0.193
0.672
0.985
3.06e-06
NA
0.0183
0.19
0.452
0.00874
0.218
0.775
0.988
1.88e-06
NA
HCC70 Buparlisib 1 72
sigmoid
sigmoid
HCC70 buparlisib 0 1 72
 8 1.374
0.608
-0.494
0.231
1.27
-0.9
1.4
0.98
7.6e-06
NA
0.988
0.151
0.861
0.98
0.00578
1.46
0.973
1.91e-05
NA
HCC38 Trametinib 2 72
sigmoid
sigmoid
HCC38 trametinib 0 2 72
 8 2.133
0.219
0.267
0.389
0.222
-0.00324
0.424
0.987
2.39e-06
NA
0.391
0.377
0.644
0.127
0.183
0.404
0.988
1.91e-06
NA
BT-20 Torin1 2 72
sigmoid
sigmoid
BT20 Torin1 0 2 72
 8 1.793
0.00766
-0.152
0.806
0.00992
-0.146
0.986
0.986
2.59e-06
NA
0.0131
0.215
0.421
0.00727
0.212
0.936
0.988
1.92e-06
NA
HCC70 Torin1 2 72
sigmoid
sigmoid
HCC70 Torin1 0 2 72
 8 1.726
0.107
0.323
0.391
0.0276
0.322
0.762
0.997
2.34e-08
NA
3.98
0.49
0.694
0.0225
0.491
0.775
0.997
1.93e-08
NA
Hs 578T Buparlisib 1
sigmoid
sigmoid
Hs578T buparlisib 1
 8 2.064
0.55
-0.579
0.308
1.29
-1.0
1.29
0.992
4.22e-07
NA
0.587
0.0401
0.759
0.587
0.0
1.31
0.988
1.94e-06
NA
HCC70 Torin2 1 72
sigmoid
sigmoid
HCC70 Torin2 0 1 72
 8 1.364
0.0288
-0.732
0.772
0.183
-1.0
0.594
0.991
6.58e-07
NA
0.088
0.0644
0.539
0.088
0.0
0.622
0.988
1.95e-06
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
HCC70 AZD-6482 1 72
sigmoid
sigmoid
HCC70 AZD6482 0 1 72
 8 1.368
0.0982
0.0128
0.462
0.205
-0.212
0.481
0.975
1.49e-05
NA
0.767
0.394
0.704
0.121
0.305
0.509
0.973
1.9e-05
NA
BT-549 AZD8055 1 72
sigmoid
sigmoid
BT549 AZD8055 0 1 72
 8 1.781
0.0305
0.165
0.526
0.0228
0.14
1.13
0.992
4.7e-07
NA
0.0615
0.382
0.599
0.0189
0.367
1.12
0.994
1.9e-07
NA
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA