Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 Dactolisib 2 72
sigmoid
sigmoid
HCC70 dactolisib 0 2 72
 8 1.677
0.312
0.238
0.341
0.195
0.103
0.493
0.954
9.66e-05
NA
2.24
0.447
0.738
0.0858
0.419
0.56
0.954
9.8e-05
NA
HCC38 WYE-125132 2 72
sigmoid
sigmoid
HCC38 WYE-132 0 2 72
 8 2.143
0.0568
0.149
0.473
0.0413
0.124
0.896
0.998
9.66e-09
NA
0.078
0.305
0.587
0.0297
0.285
0.875
0.997
1.58e-08
NA
HCC38 WYE-125132 3 72
sigmoid
sigmoid
HCC38 WYE-132 0 3 72
 8 1.449
0.0494
-0.0216
0.518
0.0504
-0.0117
1.18
0.998
9.69e-09
NA
0.128
0.355
0.662
0.0441
0.361
1.2
0.998
9.53e-09
NA
HCC38 Omipalisib 2 72
sigmoid
sigmoid
HCC38 omipalisib 0 2 72
 8 2.124
0.0404
-0.47
0.634
0.45
-1.0
0.456
0.979
9.71e-06
NA
0.0507
0.0595
0.494
0.0507
0.0
0.556
0.96
6.44e-05
NA
BT-20 Sirolimus 2 72
flat
flat
BT20 rapamycin 0 2 72
 8 1.952
Inf
0.421
0.579
0.0
0.421
0.01
NA
NA
0.421
Inf
0.513
0.513
0.0
0.513
0.01
NA
NA
0.513
BT-20 Sirolimus 3 72
flat
flat
BT20 rapamycin 0 3 72
 8 2.661
Inf
0.54
0.46
0.0
0.54
0.01
NA
NA
0.54
Inf
0.499
0.499
0.0
0.499
0.01
NA
NA
0.499
BT-20 Everolimus 2 72
flat
flat
BT20 everolimus 0 2 72
 8 1.785
Inf
0.426
0.574
0.0
0.426
0.01
NA
NA
0.426
Inf
0.547
0.547
0.0
0.547
0.01
NA
NA
0.547