Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA
HCC1806 Omipalisib 2 72
sigmoid
sigmoid
HCC1806 omipalisib 0 2 72
 8 2.849
0.112
-0.311
0.479
0.543
-0.739
0.573
0.98
8.07e-06
NA
0.0642
0.0481
0.54
0.0538
0.0749
0.919
0.979
9.93e-06
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
HCC38 Torin2 3 72
sigmoid
sigmoid
HCC38 Torin2 0 3 72
 8 1.385
0.013
-0.624
0.855
0.0547
-0.706
0.615
0.996
8.13e-08
NA
0.0407
0.0986
0.484
0.0311
0.0829
0.669
0.997
3.31e-08
NA
Hs 578T Omipalisib 1
sigmoid
sigmoid
Hs578T omipalisib 1
 8 2.079
0.00552
-0.546
0.842
0.17
-1.0
0.321
0.98
8.1e-06
NA
0.0079
0.0459
0.351
0.0079
0.0
0.369
0.984
4.12e-06
NA
HCC1806 Omipalisib 1 72
sigmoid
sigmoid
HCC1806 omipalisib 0 1 72
 8 2.764
0.104
-0.333
0.49
0.508
-0.746
0.577
0.98
8.23e-06
NA
0.0642
0.0481
0.54
0.0538
0.0749
0.919
0.979
9.93e-06
NA
HCC38 MK2206 1 72
sigmoid
sigmoid
HCC38 MK-2206 0 1 72
 8 1.789
19.4
0.698
0.0995
320.0
-0.949
0.38
0.956
8.33e-05
NA
61.8
0.746
0.914
61.8
0.0
0.386
0.951
0.000115
NA
BT-549 Torin2 3 72
sigmoid
sigmoid
BT549 Torin2 0 3 72
 8 1.613
0.00797
-0.254
0.794
0.0216
-0.338
0.517
0.98
8.52e-06
NA
0.0236
0.204
0.458
0.0104
0.191
0.585
0.976
1.3e-05
NA
HCC70 AZD8055 3 72
sigmoid
sigmoid
HCC70 AZD8055 0 3 72
 8 2.442
Inf
0.571
0.287
0.0133
0.574
1.17
0.98
8.55e-06
NA
Inf
0.554
0.694
0.0116
0.556
1.17
0.974
1.69e-05
NA
Hs 578T Omipalisib 3
sigmoid
sigmoid
Hs578T omipalisib 3
 8 2.869
0.0255
-0.107
0.615
0.0533
-0.22
0.494
0.99
8.79e-07
NA
0.0145
0.0989
0.392
0.0102
0.0968
0.62
0.993
3.4e-07
NA
BT-549 PIK-93 2 72
sigmoid
sigmoid
BT549 PIK-93 0 2 72
 8 1.983
7.03
0.687
0.0641
29.9
-1.0
0.759
0.956
8.81e-05
NA
10.4
0.713
0.939
10.4
0.0
0.788
0.949
0.000136
NA
Hs 578T WYE-125132 2
sigmoid
sigmoid
Hs578T WYE-132 2
 8 2.544
0.0374
0.152
0.505
0.0268
0.147
1.04
0.999
8.81e-10
NA
0.0344
0.246
0.516
0.0183
0.239
1.03
0.999
2.53e-09
NA
HCC70 Omipalisib 3 72
sigmoid
sigmoid
HCC70 omipalisib 0 3 72
 8 2.458
0.0158
-0.404
0.771
0.0319
-0.379
0.8
0.99
8.95e-07
NA
0.0148
0.051
0.376
0.0127
0.0733
1.02
0.996
4.59e-08
NA
Hs 578T Pictilisib 1
sigmoid
sigmoid
Hs578T pictilisib 1
 8 2.048
0.482
0.341
0.267
0.162
0.295
0.819
0.998
8.97e-09
NA
0.981
0.441
0.759
0.12
0.416
0.847
0.998
6.97e-09
NA
Hs 578T Pictilisib 2
sigmoid
sigmoid
Hs578T pictilisib 2
 8 2.512
1.93
0.45
0.194
0.4
0.333
0.696
0.98
8e-06
NA
1.58
0.446
0.787
0.231
0.381
0.746
0.974
1.74e-05
NA
BT-20 Dactolisib 1 72
sigmoid
sigmoid
BT20 dactolisib 0 1 72
 8 2.055
0.0223
-0.205
0.652
0.0609
-0.33
0.505
0.979
9.18e-06
NA
0.0305
0.15
0.475
0.0171
0.153
0.631
0.979
9.75e-06
NA
HCC70 Torin2 2 72
sigmoid
sigmoid
HCC70 Torin2 0 2 72
 8 1.826
0.0342
-0.522
0.671
0.401
-1.0
0.446
0.979
9.23e-06
NA
0.0639
0.0733
0.507
0.0639
0.0
0.462
0.969
2.98e-05
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
HCC38 Buparlisib 1 72
sigmoid
sigmoid
HCC38 buparlisib 0 1 72
 8 1.738
0.912
-0.226
0.194
1.46
-0.57
1.62
0.999
9.48e-10
NA
1.2
0.192
0.858
1.12
0.0495
1.66
0.998
4.36e-09
NA
Hs 578T Alpelisib 1
sigmoid
sigmoid
Hs578T alpelisib 1
 8 2.097
2.3
0.449
0.205
42.0
-1.0
0.378
0.954
9.56e-05
NA
3.9
0.508
0.803
3.9
0.0
0.401
0.94
0.000216
NA
Hs 578T CAL-101 2
sigmoid
sigmoid
Hs578T idelalisib 2
 8 2.534
57.5
0.801
0.0636
320.0
-0.507
0.408
0.979
9.58e-06
NA
Inf
0.766
0.923
4.27
0.505
0.495
0.975
1.65e-05
NA
HCC38 BX-912 2 72
sigmoid
sigmoid
HCC38 BX-912 0 2 72
 8 2.186
0.583
-0.229
0.251
0.648
-0.233
3.62
0.999
9.58e-10
NA
0.602
0.124
0.807
0.559
0.123
3.78
0.998
1.03e-08
NA
BT-20 Pictilisib 3 72
sigmoid
sigmoid
BT20 pictilisib 0 3 72
 8 2.566
0.839
0.172
0.22
0.914
-0.0483
1.09
0.954
9.59e-05
NA
0.843
0.254
0.768
0.809
0.0179
0.898
0.918
0.000551
NA
BT-549 Pictilisib 3 72
sigmoid
sigmoid
BT549 pictilisib 0 3 72
 8 1.767
1.42
0.276
0.169
4.62
-0.67
0.722
0.998
9.61e-09
NA
2.47
0.452
0.863
2.47
0.0
0.742
0.997
2.13e-08
NA