Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 Torin2 1 72
sigmoid
sigmoid
HCC70 Torin2 0 1 72
 8 1.364
0.0288
-0.732
0.772
0.183
-1.0
0.594
0.991
6.58e-07
NA
0.088
0.0644
0.539
0.088
0.0
0.622
0.988
1.95e-06
NA
HCC38 Torin2 1 72
sigmoid
sigmoid
HCC38 Torin2 0 1 72
 8 1.778
0.0133
-0.318
0.753
0.0337
-0.369
0.594
0.994
1.98e-07
NA
0.0264
0.148
0.459
0.0158
0.145
0.664
0.994
1.7e-07
NA
BT-549 Torin2 2 72
sigmoid
sigmoid
BT549 Torin2 0 2 72
 8 1.824
0.00997
-0.281
0.767
0.0212
-0.282
0.594
0.975
1.47e-05
NA
0.0177
0.155
0.438
0.00929
0.188
0.734
0.973
2.02e-05
NA
BT-20 Omipalisib 1 72
sigmoid
sigmoid
BT20 omipalisib 0 1 72
 8 2.078
0.00617
-0.729
0.985
0.0283
-0.739
0.596
0.97
2.83e-05
NA
0.00781
0.0157
0.306
0.00685
0.0597
0.96
0.988
1.57e-06
NA
BT-549 Pictilisib 2 72
sigmoid
sigmoid
BT549 pictilisib 0 2 72
 8 1.960
1.84
0.365
0.166
11.5
-1.0
0.599
0.943
0.000187
NA
2.82
0.473
0.851
2.82
0.0
0.647
0.924
0.000432
NA
HCC38 Omipalisib 3 72
sigmoid
sigmoid
HCC38 omipalisib 0 3 72
 8 1.446
0.0145
-0.503
0.802
0.0539
-0.597
0.6
0.993
3.08e-07
NA
0.0449
0.134
0.499
0.0308
0.107
0.644
0.993
2.98e-07
NA
BT-549 Trametinib 1 72
sigmoid
sigmoid
BT549 trametinib 0 1 72
 8 1.812
Inf
0.596
0.202
0.131
0.523
0.61
0.959
6.65e-05
NA
28.3
0.664
0.828
3.47
0.254
0.337
0.933
0.000305
NA
HCC38 Torin2 3 72
sigmoid
sigmoid
HCC38 Torin2 0 3 72
 8 1.385
0.013
-0.624
0.855
0.0547
-0.706
0.615
0.996
8.13e-08
NA
0.0407
0.0986
0.484
0.0311
0.0829
0.669
0.997
3.31e-08
NA
BT-20 WYE-125132 2 72
sigmoid
sigmoid
BT20 WYE-132 0 2 72
 8 2.053
0.012
0.142
0.633
0.00936
0.072
0.621
0.909
0.000752
NA
0.0232
0.316
0.475
0.00613
0.255
0.536
0.894
0.00119
NA
Hs 578T PIK-93 1
sigmoid
sigmoid
Hs578T PIK-93 1
 8 2.033
1.44
0.276
0.175
8.38
-1.0
0.624
0.991
6.57e-07
NA
2.0
0.401
0.84
2.0
0.0
0.672
0.99
9.72e-07
NA
BT-549 TGX221 1 72
sigmoid
sigmoid
BT549 TGX-221 0 1 72
 8 1.826
Inf
0.821
0.0771
0.297
0.777
0.632
0.868
0.00232
NA
Inf
0.842
0.931
0.313
0.799
0.603
0.863
0.00255
NA
HCC70 PIK-93 1 72
sigmoid
sigmoid
HCC70 PIK-93 0 1 72
 8 1.442
3.47
0.482
0.137
18.6
-1.0
0.656
0.774
0.0116
NA
10.7
0.649
0.904
10.7
0.0
0.632
0.746
0.0163
NA
BT-20 MK2206 2 72
sigmoid
sigmoid
BT20 MK-2206 0 2 72
 8 1.739
0.823
0.0896
0.246
4.34
-1.0
0.661
0.965
4.36e-05
NA
1.47
0.348
0.806
1.47
0.0
0.715
0.947
0.000145
NA
HCC1806 Torin1 3 72
sigmoid
sigmoid
HCC1806 Torin1 0 3 72
 8 3.208
0.537
0.332
0.278
0.165
0.271
0.662
0.988
1.91e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
HCC1806 Torin1 2 72
sigmoid
sigmoid
HCC1806 Torin1 0 2 72
 8 2.840
0.336
0.264
0.309
0.154
0.203
0.668
0.988
1.77e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
HCC1806 Torin1 1 72
sigmoid
sigmoid
HCC1806 Torin1 0 1 72
 8 2.755
0.303
0.246
0.317
0.152
0.185
0.669
0.988
1.74e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
BT-549 Torin2 1 72
sigmoid
sigmoid
BT549 Torin2 0 1 72
 8 1.771
0.0095
-0.218
0.756
0.0155
-0.193
0.672
0.985
3.06e-06
NA
0.0183
0.19
0.452
0.00874
0.218
0.775
0.988
1.88e-06
NA
BT-20 AZD-6482 3 72
sigmoid
sigmoid
BT20 AZD6482 0 3 72
 8 2.601
1.68
0.3
0.173
8.38
-1.0
0.685
0.959
6.72e-05
NA
1.5
0.326
0.805
1.5
0.0
0.733
0.925
0.000414
NA
Hs 578T CAL-101 1
sigmoid
sigmoid
Hs578T idelalisib 1
 8 2.050
27.9
0.72
0.0764
4.56
0.356
0.688
0.945
0.000168
NA
18.7
0.734
0.925
18.7
0.0
0.568
0.941
0.000203
NA
BT-549 CAL-101 2 72
sigmoid
sigmoid
BT549 idelalisib 0 2 72
 8 1.975
Inf
0.792
0.0561
4.65
0.526
0.693
0.933
0.000307
NA
43.0
0.805
0.946
43.0
0.0
0.548
0.932
0.000314
NA
Hs 578T Pictilisib 2
sigmoid
sigmoid
Hs578T pictilisib 2
 8 2.512
1.93
0.45
0.194
0.4
0.333
0.696
0.98
8e-06
NA
1.58
0.446
0.787
0.231
0.381
0.746
0.974
1.74e-05
NA
BT-20 Alpelisib 3 72
sigmoid
sigmoid
BT20 alpelisib 0 3 72
 8 2.541
1.21
0.199
0.21
5.83
-1.0
0.697
0.881
0.00167
NA
1.12
0.272
0.775
1.12
0.0
0.764
0.791
0.00916
NA
HCC38 Torin1 3 72
sigmoid
sigmoid
HCC38 Torin1 0 3 72
 8 1.441
0.0231
-0.202
0.666
0.0412
-0.248
0.698
0.999
5.79e-10
NA
0.0787
0.266
0.572
0.0306
0.245
0.714
0.999
5.55e-10
NA
HCC70 AS605240 2 72
sigmoid
sigmoid
HCC70 AS-605240 0 2 72
 8 1.771
6.13
0.558
0.126
1.21
0.339
0.698
0.981
7.24e-06
NA
785.0
0.643
0.894
0.946
0.496
0.708
0.978
1.04e-05
NA