Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 WYE-125132 2 72
sigmoid
sigmoid
HCC1806 WYE-132 0 2 72
 8 2.874
0.872
0.479
0.284
0.045
0.464
0.883
0.997
3.66e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
HCC1806 WYE-125132 1 72
sigmoid
sigmoid
HCC1806 WYE-132 0 1 72
 8 2.790
0.603
0.466
0.292
0.0448
0.45
0.883
0.997
3.72e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
HCC1806 WYE-125132 3 72
sigmoid
sigmoid
HCC1806 WYE-132 0 3 72
 8 3.242
Inf
0.531
0.255
0.0458
0.517
0.885
0.997
3.48e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
BT-549 Omipalisib 1 72
sigmoid
sigmoid
BT549 omipalisib 0 1 72
 8 1.789
0.0164
-0.2
0.693
0.0219
-0.149
0.887
0.986
2.66e-06
NA
0.0272
0.194
0.495
0.0148
0.228
0.993
0.991
8.42e-07
NA
BT-20 AZD8055 3 72
sigmoid
sigmoid
BT20 AZD8055 0 3 72
 8 2.694
0.0351
0.345
0.472
0.0116
0.313
0.89
0.934
0.000286
NA
0.0291
0.343
0.506
0.00813
0.306
0.743
0.922
0.000471
NA
HCC38 Dactolisib 1 72
sigmoid
sigmoid
HCC38 dactolisib 0 1 72
 8 1.821
0.0109
-0.0403
0.672
0.0104
0.0212
0.892
0.985
3.44e-06
NA
0.0194
0.263
0.492
0.00757
0.301
0.975
0.988
1.65e-06
NA
BT-20 AZD-6482 1 72
sigmoid
sigmoid
BT20 AZD6482 0 1 72
 8 2.043
1.34
0.182
0.173
3.83
-0.782
0.893
0.982
5.6e-06
NA
1.65
0.342
0.845
1.65
0.0
0.977
0.972
2.09e-05
NA
BT-20 ZSTK474 3 72
sigmoid
sigmoid
BT20 ZSTK474 0 3 72
 8 2.609
0.457
-0.00222
0.296
0.783
-0.31
0.895
0.982
5.76e-06
NA
0.422
0.163
0.702
0.422
0.0
0.82
0.971
2.52e-05
NA
HCC38 WYE-125132 2 72
sigmoid
sigmoid
HCC38 WYE-132 0 2 72
 8 2.143
0.0568
0.149
0.473
0.0413
0.124
0.896
0.998
9.66e-09
NA
0.078
0.305
0.587
0.0297
0.285
0.875
0.997
1.58e-08
NA
HCC70 AZD8055 2 72
sigmoid
sigmoid
HCC70 AZD8055 0 2 72
 8 1.724
0.17
0.404
0.346
0.0331
0.385
0.897
0.996
7.36e-08
NA
Inf
0.543
0.728
0.0284
0.531
0.905
0.996
6.22e-08
NA
Hs 578T PI103 1
sigmoid
sigmoid
Hs578T PI-103 1
 8 2.062
0.131
-0.0743
0.433
0.182
-0.173
0.898
0.996
4.43e-08
NA
0.175
0.204
0.643
0.117
0.152
0.898
0.995
1.02e-07
NA
BT-20 Torin1 3 72
sigmoid
sigmoid
BT20 Torin1 0 3 72
 8 2.569
0.0237
0.0343
0.572
0.0199
0.0736
0.899
0.993
2.77e-07
NA
0.0208
0.184
0.46
0.0119
0.204
0.944
0.997
2.51e-08
NA
BT-549 Trametinib 3 72
sigmoid
sigmoid
BT549 trametinib 0 3 72
 8 1.755
Inf
0.553
0.223
0.107
0.505
0.899
0.942
0.000194
NA
Inf
0.642
0.817
0.104
0.595
0.804
0.938
0.000236
NA
Hs 578T Dactolisib 1
sigmoid
sigmoid
Hs578T dactolisib 1
 8 2.047
0.00952
-0.0606
0.691
0.00928
0.0117
0.91
0.977
1.27e-05
NA
0.0124
0.213
0.443
0.00621
0.259
1.06
0.985
3.61e-06
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
Hs 578T Torin1 1
sigmoid
sigmoid
Hs578T Torin1 1
 8 1.956
0.0217
0.0183
0.598
0.0203
0.0286
0.911
0.994
1.81e-07
NA
0.0321
0.267
0.524
0.0141
0.28
0.995
0.996
8.78e-08
NA
HCC38 AZD8055 2 72
sigmoid
sigmoid
HCC38 AZD8055 0 2 72
 8 2.128
0.0616
0.16
0.467
0.045
0.124
0.912
0.993
3.13e-07
NA
0.0875
0.314
0.594
0.0332
0.284
0.869
0.991
6.5e-07
NA
BT-549 AZD8055 3 72
sigmoid
sigmoid
BT549 AZD8055 0 3 72
 8 1.757
0.0178
0.159
0.59
0.0122
0.145
0.913
0.942
0.000193
NA
0.0479
0.383
0.555
0.00973
0.372
0.854
0.954
9.74e-05
NA
Hs 578T AS605240 1
sigmoid
sigmoid
Hs578T AS-605240 1
 8 2.015
0.758
0.341
0.212
0.333
0.265
0.921
0.991
7.83e-07
NA
1.42
0.447
0.811
0.246
0.408
0.964
0.989
1.51e-06
NA
BT-20 WYE-125132 3 72
sigmoid
sigmoid
BT20 WYE-132 0 3 72
 8 2.654
0.0504
0.282
0.465
0.0254
0.236
0.929
0.922
0.000468
NA
0.048
0.307
0.526
0.0182
0.246
0.698
0.918
0.000553
NA
HCC38 GDC-0980 3 72
sigmoid
sigmoid
HCC38 apitolisib 0 3 72
 8 1.437
0.371
-0.0189
0.29
0.513
-0.179
0.946
0.993
3.35e-07
NA
0.96
0.359
0.808
0.393
0.295
0.998
0.993
3.51e-07
NA
HCC70 Trametinib 3 72
sigmoid
sigmoid
HCC70 trametinib 0 3 72
 8 2.463
Inf
0.56
0.361
0.00419
0.548
0.954
0.95
0.000123
NA
Inf
0.542
0.618
0.00342
0.533
0.965
0.958
7.33e-05
NA
Hs 578T GDC-0980 1
sigmoid
sigmoid
Hs578T apitolisib 1
 8 1.984
0.119
-0.0587
0.419
0.141
-0.0865
0.957
0.997
3.35e-08
NA
0.161
0.224
0.662
0.0914
0.223
1.04
0.997
2.87e-08
NA
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA