Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
HCC70	Omipalisib	3	72	sigmoid	sigmoid	HCC70 omipalisib 0 3 72	8	2.458	0.0158	-0.404	0.771	0.0319	-0.379	0.8	0.99	8.95e-07	NA	0.0148	0.051	0.376	0.0127	0.0733	1.02	0.996	4.59e-08	NA
HCC70	Omipalisib	1	72	sigmoid	sigmoid	HCC70 omipalisib 0 1 72	8	1.358	0.00496	-0.785	1.14	0.0157	-0.775	0.812	0.989	1.34e-06	NA	0.0123	0.0486	0.349	0.011	0.0462	0.833	0.984	3.73e-06	NA
Hs 578T	Pictilisib	1		sigmoid	sigmoid	Hs578T pictilisib 1	8	2.048	0.482	0.341	0.267	0.162	0.295	0.819	0.998	8.97e-09	NA	0.981	0.441	0.759	0.12	0.416	0.847	0.998	6.97e-09	NA
HCC38	Torin1	2	72	sigmoid	sigmoid	HCC38 Torin1 0 2 72	8	2.136	0.0241	0.0393	0.573	0.0203	0.0651	0.82	0.995	1.24e-07	NA	0.0309	0.247	0.512	0.013	0.267	0.88	0.996	4.87e-08	NA
Hs 578T	Alpelisib	3		sigmoid	sigmoid	Hs578T alpelisib 3	8	2.856	Inf	0.712	0.0759	0.872	0.616	0.828	0.963	5.21e-05	NA	Inf	0.641	0.901	0.65	0.553	0.853	0.955	8.85e-05	NA
HCC1806	Pictilisib	1	72	sigmoid	sigmoid	HCC1806 pictilisib 0 1 72	8	2.782	11.7	0.79	0.049	43.7	-1.0	0.831	0.811	0.00677	NA	11.3	0.734	0.935	11.3	0.0	0.849	0.773	0.0116	NA
HCC1806	Pictilisib	2	72	sigmoid	sigmoid	HCC1806 pictilisib 0 2 72	8	2.866	12.1	0.796	0.0476	45.4	-1.0	0.831	0.811	0.00671	NA	11.3	0.734	0.935	11.3	0.0	0.849	0.773	0.0116	NA
HCC1806	Pictilisib	3	72	sigmoid	sigmoid	HCC1806 pictilisib 0 3 72	8	3.234	14.1	0.818	0.0423	52.2	-0.98	0.831	0.814	0.00649	NA	11.3	0.734	0.935	11.3	0.0	0.849	0.773	0.0116	NA
BT-549	ZSTK474	3	72	sigmoid	sigmoid	BT549 ZSTK474 0 3 72	8	1.776	0.504	0.139	0.267	0.616	-0.0912	0.836	0.996	7.06e-08	NA	0.994	0.368	0.789	0.489	0.218	0.808	0.995	9.19e-08	NA
BT-549	Trametinib	2	72	sigmoid	sigmoid	BT549 trametinib 0 2 72	8	1.914	Inf	0.602	0.2	0.0685	0.581	0.837	0.995	1.05e-07	NA	Inf	0.654	0.822	0.0601	0.638	0.839	0.995	1.04e-07	NA
BT-549	ZSTK474	2	72	sigmoid	sigmoid	BT549 ZSTK474 0 2 72	8	1.962	0.628	0.144	0.245	0.841	-0.139	0.84	0.995	1.29e-07	NA	0.958	0.334	0.791	0.595	0.163	0.828	0.992	4.28e-07	NA
HCC38	ZSTK474	1	72	sigmoid	sigmoid	HCC38 ZSTK474 0 1 72	8	1.742	2.47	0.456	0.132	1.34	0.202	0.843	0.991	7.12e-07	NA	9.02	0.575	0.893	1.0	0.426	0.869	0.99	1.01e-06	NA
HCC38	Torin1	1	72	sigmoid	sigmoid	HCC38 Torin1 0 1 72	8	1.688	0.0287	-0.0113	0.569	0.0278	0.013	0.843	0.993	4.14e-07	NA	0.0653	0.304	0.585	0.0204	0.325	0.9	0.992	4.53e-07	NA
Hs 578T	TGX221	3		sigmoid	sigmoid	Hs578T TGX-221 3	8	2.818	24.2	0.885	0.0148	88.9	-1.0	0.843	0.958	7.66e-05	NA	23.4	0.846	0.98	23.4	0.0	0.862	0.953	0.000103	NA
Hs 578T	ZSTK474	3		sigmoid	sigmoid	Hs578T ZSTK474 3	8	2.863	0.913	0.31	0.201	0.613	0.143	0.846	0.999	6.21e-10	NA	0.607	0.298	0.767	0.329	0.211	0.895	0.999	1.43e-09	NA
HCC70	Torin1	1	72	sigmoid	sigmoid	HCC70 Torin1 0 1 72	8	1.345	0.0472	0.15	0.487	0.0311	0.149	0.849	0.973	1.89e-05	NA	0.93	0.475	0.693	0.0276	0.475	0.854	0.973	2.05e-05	NA
Hs 578T	ZSTK474	1		sigmoid	sigmoid	Hs578T ZSTK474 1	8	1.968	0.325	0.137	0.279	0.265	0.0807	0.854	0.973	1.94e-05	NA	0.471	0.329	0.764	0.149	0.343	1.01	0.972	2.27e-05	NA
Hs 578T	PI103	2		sigmoid	sigmoid	Hs578T PI-103 2	8	2.503	0.223	-0.0213	0.356	0.303	-0.15	0.858	0.999	7.33e-10	NA	0.206	0.167	0.661	0.152	0.121	0.921	0.999	1.9e-09	NA
BT-549	Dactolisib	3	72	sigmoid	sigmoid	BT549 dactolisib 0 3 72	8	1.801	0.0058	-0.00929	0.751	0.00579	0.000747	0.866	0.994	2.41e-07	NA	0.011	0.282	0.442	0.00425	0.29	0.909	0.995	1.54e-07	NA
HCC1806	Trametinib	3	72	sigmoid	sigmoid	HCC1806 trametinib 0 3 72	8	3.204	Inf	0.822	0.12	0.00981	0.829	0.872	0.97	2.67e-05	NA	Inf	0.742	0.822	0.00864	0.752	0.892	0.97	2.67e-05	NA
HCC1806	Trametinib	2	72	sigmoid	sigmoid	HCC1806 trametinib 0 2 72	8	2.836	Inf	0.8	0.135	0.00973	0.808	0.873	0.97	2.67e-05	NA	Inf	0.742	0.822	0.00864	0.752	0.892	0.97	2.67e-05	NA
HCC1806	Trametinib	1	72	sigmoid	sigmoid	HCC1806 trametinib 0 1 72	8	2.751	Inf	0.795	0.139	0.00972	0.802	0.873	0.97	2.67e-05	NA	Inf	0.742	0.822	0.00864	0.752	0.892	0.97	2.67e-05	NA
BT-549	Omipalisib	3	72	sigmoid	sigmoid	BT549 omipalisib 0 3 72	8	1.777	0.0114	-0.23	0.753	0.0162	-0.178	0.879	0.988	1.64e-06	NA	0.0201	0.183	0.459	0.0112	0.208	0.924	0.991	6.53e-07	NA
HCC70	Trametinib	1	72	sigmoid	sigmoid	HCC70 trametinib 0 1 72	8	1.421	0.015	0.339	0.521	0.00411	0.34	0.879	0.966	4.1e-05	NA	Inf	0.566	0.653	0.00373	0.566	0.875	0.968	3.23e-05	NA
HCC38	AS605240	1	72	sigmoid	sigmoid	HCC38 AS-605240 0 1 72	8	1.744	Inf	0.734	0.0803	0.448	0.691	0.881	0.969	2.92e-05	NA	Inf	0.78	0.932	0.405	0.748	0.895	0.967	3.48e-05	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)