Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC38 XL147 3 72
sigmoid
sigmoid
HCC38 pilaralisib 0 3 72
 8 1.420
Inf
0.909
0.0219
0.114
0.921
5.0
0.815
0.00631
NA
Inf
0.936
0.985
0.114
0.945
5.0
0.813
0.00654
NA
BT-549 BX-912 2 72
sigmoid
sigmoid
BT549 BX-912 0 2 72
 8 1.948
1.04
0.33
0.126
0.84
0.329
5.0
0.99
1.01e-06
NA
1.28
0.452
0.892
0.808
0.451
5.0
0.987
2.4e-06
NA
HCC38 TGX221 1 72
sigmoid
sigmoid
HCC38 TGX-221 0 1 72
 8 1.724
Inf
0.938
0.0116
0.289
0.941
5.0
0.676
0.0342
NA
Inf
0.947
0.99
0.289
0.949
5.0
0.672
0.0354
NA
HCC38 BX-912 3 72
sigmoid
sigmoid
HCC38 BX-912 0 3 72
 8 1.454
0.422
-0.428
0.365
0.478
-0.433
5.0
0.993
4.02e-07
NA
0.496
0.162
0.778
0.46
0.159
5.0
0.989
1.24e-06
NA
HCC70 BX-912 3 72
sigmoid
sigmoid
HCC70 BX-912 0 3 72
 8 2.465
1.26
0.174
0.0739
1.16
0.168
5.0
0.988
1.75e-06
NA
1.26
0.269
0.935
1.08
0.265
5.0
0.977
1.15e-05
NA
HCC70 BX-912 2 72
sigmoid
sigmoid
HCC70 BX-912 0 2 72
 8 1.693
1.25
0.00257
0.0619
1.25
-0.00649
5.0
0.971
2.55e-05
NA
1.44
0.311
0.961
1.2
0.306
5.0
0.956
8.35e-05
NA
BT-549 MK2206 2 72
sigmoid
sigmoid
BT549 MK-2206 0 2 72
 8 1.871
Inf
0.926
0.0188
0.107
0.926
5.0
0.816
0.00627
NA
Inf
0.932
0.983
0.107
0.931
5.0
0.809
0.00694
NA