Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-549 | Dactolisib | 3 | 72 | sigmoid | sigmoid | BT549 dactolisib 0 3 72 | 8 | 1.801 | 0.0058 | -0.00929 | 0.751 | 0.00579 | 0.000747 | 0.866 | 0.994 | 2.41e-07 | NA | 0.011 | 0.282 | 0.442 | 0.00425 | 0.29 | 0.909 | 0.995 | 1.54e-07 | NA |
HCC1806 | Omipalisib | 1 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 1 72 | 8 | 2.764 | 0.104 | -0.333 | 0.49 | 0.508 | -0.746 | 0.577 | 0.98 | 8.23e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
HCC1806 | Omipalisib | 3 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 3 72 | 8 | 3.217 | 0.147 | -0.221 | 0.437 | 0.71 | -0.707 | 0.559 | 0.981 | 7.41e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
HCC1806 | Omipalisib | 2 | 72 | sigmoid | sigmoid | HCC1806 omipalisib 0 2 72 | 8 | 2.849 | 0.112 | -0.311 | 0.479 | 0.543 | -0.739 | 0.573 | 0.98 | 8.07e-06 | NA | 0.0642 | 0.0481 | 0.54 | 0.0538 | 0.0749 | 0.919 | 0.979 | 9.93e-06 | NA |
Hs 578T | PI103 | 2 | sigmoid | sigmoid | Hs578T PI-103 2 | 8 | 2.503 | 0.223 | -0.0213 | 0.356 | 0.303 | -0.15 | 0.858 | 0.999 | 7.33e-10 | NA | 0.206 | 0.167 | 0.661 | 0.152 | 0.121 | 0.921 | 0.999 | 1.9e-09 | NA | |
BT-549 | Omipalisib | 3 | 72 | sigmoid | sigmoid | BT549 omipalisib 0 3 72 | 8 | 1.777 | 0.0114 | -0.23 | 0.753 | 0.0162 | -0.178 | 0.879 | 0.988 | 1.64e-06 | NA | 0.0201 | 0.183 | 0.459 | 0.0112 | 0.208 | 0.924 | 0.991 | 6.53e-07 | NA |
HCC38 | Dactolisib | 2 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 2 72 | 8 | 2.120 | 0.0118 | -0.0557 | 0.668 | 0.0118 | -0.00134 | 0.785 | 0.98 | 7.61e-06 | NA | 0.0145 | 0.204 | 0.447 | 0.00701 | 0.245 | 0.927 | 0.988 | 1.88e-06 | NA |
BT-20 | Torin1 | 2 | 72 | sigmoid | sigmoid | BT20 Torin1 0 2 72 | 8 | 1.793 | 0.00766 | -0.152 | 0.806 | 0.00992 | -0.146 | 0.986 | 0.986 | 2.59e-06 | NA | 0.0131 | 0.215 | 0.421 | 0.00727 | 0.212 | 0.936 | 0.988 | 1.92e-06 | NA |
Hs 578T | AZD8055 | 1 | sigmoid | sigmoid | Hs578T AZD8055 1 | 8 | 2.009 | 0.0391 | 0.073 | 0.531 | 0.0347 | 0.0546 | 0.975 | 0.995 | 1.39e-07 | NA | 0.0591 | 0.286 | 0.565 | 0.0259 | 0.27 | 0.941 | 0.994 | 1.73e-07 | NA | |
BT-20 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | BT20 WYE-132 0 1 72 | 8 | 2.067 | 0.0893 | 0.289 | 0.402 | 0.0435 | 0.256 | 1.0 | 0.987 | 2.28e-06 | NA | 0.154 | 0.403 | 0.647 | 0.0353 | 0.375 | 0.941 | 0.985 | 3.56e-06 | NA |
BT-20 | Torin1 | 3 | 72 | sigmoid | sigmoid | BT20 Torin1 0 3 72 | 8 | 2.569 | 0.0237 | 0.0343 | 0.572 | 0.0199 | 0.0736 | 0.899 | 0.993 | 2.77e-07 | NA | 0.0208 | 0.184 | 0.46 | 0.0119 | 0.204 | 0.944 | 0.997 | 2.51e-08 | NA |
BT-20 | Omipalisib | 3 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 3 72 | 8 | 2.586 | 0.00689 | -0.587 | 0.893 | 0.044 | -0.714 | 0.478 | 0.958 | 7.32e-05 | NA | 0.00572 | 0.017 | 0.281 | 0.00491 | 0.0669 | 0.945 | 0.983 | 4.7e-06 | NA |
HCC38 | GDC-0980 | 1 | 72 | sigmoid | sigmoid | HCC38 apitolisib 0 1 72 | 8 | 1.777 | 0.317 | 0.114 | 0.305 | 0.295 | 0.0315 | 0.91 | 0.99 | 9.47e-07 | NA | 0.623 | 0.354 | 0.761 | 0.219 | 0.315 | 0.951 | 0.989 | 1.26e-06 | NA |
Hs 578T | Pictilisib | 3 | sigmoid | sigmoid | Hs578T pictilisib 3 | 8 | 2.911 | 2.33 | 0.471 | 0.168 | 0.364 | 0.403 | 0.883 | 0.996 | 5.24e-08 | NA | 0.97 | 0.409 | 0.794 | 0.228 | 0.374 | 0.952 | 0.996 | 5.98e-08 | NA | |
BT-20 | Omipalisib | 1 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 1 72 | 8 | 2.078 | 0.00617 | -0.729 | 0.985 | 0.0283 | -0.739 | 0.596 | 0.97 | 2.83e-05 | NA | 0.00781 | 0.0157 | 0.306 | 0.00685 | 0.0597 | 0.96 | 0.988 | 1.57e-06 | NA |
Hs 578T | AS605240 | 1 | sigmoid | sigmoid | Hs578T AS-605240 1 | 8 | 2.015 | 0.758 | 0.341 | 0.212 | 0.333 | 0.265 | 0.921 | 0.991 | 7.83e-07 | NA | 1.42 | 0.447 | 0.811 | 0.246 | 0.408 | 0.964 | 0.989 | 1.51e-06 | NA | |
HCC70 | Trametinib | 3 | 72 | sigmoid | sigmoid | HCC70 trametinib 0 3 72 | 8 | 2.463 | Inf | 0.56 | 0.361 | 0.00419 | 0.548 | 0.954 | 0.95 | 0.000123 | NA | Inf | 0.542 | 0.618 | 0.00342 | 0.533 | 0.965 | 0.958 | 7.33e-05 | NA |
BT-549 | Torin1 | 1 | 72 | sigmoid | sigmoid | BT549 Torin1 0 1 72 | 8 | 1.794 | 0.017 | 0.0603 | 0.621 | 0.0151 | 0.056 | 0.976 | 0.998 | 7.25e-09 | NA | 0.0333 | 0.32 | 0.532 | 0.0118 | 0.316 | 0.966 | 0.998 | 9.27e-09 | NA |
Hs 578T | WYE-125132 | 3 | sigmoid | sigmoid | Hs578T WYE-132 3 | 8 | 2.876 | 0.0568 | 0.189 | 0.452 | 0.0346 | 0.192 | 0.975 | 0.996 | 7.69e-08 | NA | 0.0403 | 0.224 | 0.522 | 0.0221 | 0.221 | 0.97 | 0.993 | 4.12e-07 | NA | |
HCC38 | Dactolisib | 1 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 1 72 | 8 | 1.821 | 0.0109 | -0.0403 | 0.672 | 0.0104 | 0.0212 | 0.892 | 0.985 | 3.44e-06 | NA | 0.0194 | 0.263 | 0.492 | 0.00757 | 0.301 | 0.975 | 0.988 | 1.65e-06 | NA |
BT-20 | AZD-6482 | 1 | 72 | sigmoid | sigmoid | BT20 AZD6482 0 1 72 | 8 | 2.043 | 1.34 | 0.182 | 0.173 | 3.83 | -0.782 | 0.893 | 0.982 | 5.6e-06 | NA | 1.65 | 0.342 | 0.845 | 1.65 | 0.0 | 0.977 | 0.972 | 2.09e-05 | NA |
Hs 578T | WYE-125132 | 1 | sigmoid | sigmoid | Hs578T WYE-132 1 | 8 | 2.015 | 0.0322 | 0.0601 | 0.551 | 0.0286 | 0.0544 | 0.962 | 0.998 | 4.17e-09 | NA | 0.0469 | 0.278 | 0.55 | 0.0207 | 0.275 | 0.978 | 0.999 | 2.33e-09 | NA | |
HCC38 | AZD8055 | 1 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 1 72 | 8 | 1.773 | 0.052 | 0.151 | 0.479 | 0.0381 | 0.136 | 1.02 | 0.992 | 4.28e-07 | NA | 0.116 | 0.375 | 0.633 | 0.0313 | 0.363 | 0.987 | 0.993 | 3.89e-07 | NA |
Hs 578T | AZD8055 | 3 | sigmoid | sigmoid | Hs578T AZD8055 3 | 8 | 2.886 | 0.0538 | 0.232 | 0.451 | 0.0311 | 0.22 | 1.06 | 0.995 | 1.13e-07 | NA | 0.039 | 0.247 | 0.521 | 0.0208 | 0.231 | 0.989 | 0.995 | 1.55e-07 | NA | |
Hs 578T | KIN001-244 | 1 | sigmoid | sigmoid | Hs578T KIN001-244 1 | 8 | 2.041 | 24.7 | 0.739 | 0.0391 | 4.05 | 0.414 | 0.972 | 0.968 | 3.4e-05 | NA | Inf | 0.752 | 0.962 | 3.15 | 0.51 | 0.99 | 0.964 | 4.65e-05 | NA |