Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	Everolimus	2	72	flat	flat	BT20 everolimus 0 2 72	8	1.785	Inf	0.426	0.574	0.0	0.426	0.01	NA	NA	0.426	Inf	0.547	0.547	0.0	0.547	0.01	NA	NA	0.547
BT-20	Everolimus	3	72	flat	flat	BT20 everolimus 0 3 72	8	2.422	Inf	0.475	0.456	0.0	0.475	0.01	0.602	0.0632	0.543	Inf	0.478	0.534	0.0	0.478	0.01	0.561	0.0844	0.534
BT-20	CAL-101	1	72	flat	flat	BT20 idelalisib 0 1 72	8	2.112	Inf	0.869	0.0546	0.0	0.869	0.01	0.0807	0.777	0.938	Inf	0.867	0.943	0.0	0.867	0.01	0.0778	0.784	0.936
BT-20	CAL-101	2	72	flat	flat	BT20 idelalisib 0 2 72	8	1.768	Inf	0.818	0.0943	0.0	0.818	0.01	0.226	0.463	0.898	Inf	0.845	0.918	0.0	0.845	0.01	0.222	0.471	0.912
BT-20	CAL-101	3	72	flat	flat	BT20 idelalisib 0 3 72	8	2.589	Inf	0.916	0.0535	0.0	0.916	0.01	0.0547	0.845	0.944	Inf	0.894	0.932	0.0	0.894	0.01	0.0506	0.856	0.929
BT-20	KIN001-244	1	72	flat	flat	BT20 KIN001-244 0 1 72	8	2.125	Inf	0.911	0.0401	0.0	0.911	0.01	-0.00641	1.0	0.957	Inf	0.908	0.958	0.0	0.908	0.01	-0.00745	1.0	0.955
BT-20	KIN001-244	2	72	sigmoid	sigmoid	BT20 KIN001-244 0 2 72	8	1.742	Inf	0.85	0.0644	4.47	0.713	0.316	0.721	0.0218	NA	Inf	0.873	0.945	4.51	0.757	0.309	0.715	0.0231	NA
BT-20	KIN001-244	3	72	flat	flat	BT20 KIN001-244 0 3 72	8	2.608	Inf	0.841	0.062	0.0	0.841	0.01	0.489	0.133	0.935	Inf	0.805	0.922	0.0	0.805	0.01	0.475	0.145	0.919
BT-20	MK2206	1	72	sigmoid	sigmoid	BT20 MK-2206 0 1 72	8	2.089	Inf	0.732	0.102	4.16	0.529	0.345	0.671	0.0357	NA	Inf	0.741	0.898	4.14	0.538	0.337	0.676	0.034	NA
BT-20	MK2206	2	72	sigmoid	sigmoid	BT20 MK-2206 0 2 72	8	1.739	0.823	0.0896	0.246	4.34	-1.0	0.661	0.965	4.36e-05	NA	1.47	0.348	0.806	1.47	0.0	0.715	0.947	0.000145	NA
BT-20	MK2206	3	72	sigmoid	sigmoid	BT20 MK-2206 0 3 72	8	2.449	1.73	0.252	0.12	3.23	-0.504	1.11	0.988	1.77e-06	NA	1.69	0.318	0.877	1.69	0.0	1.18	0.979	9.03e-06	NA
BT-20	Omipalisib	1	72	sigmoid	sigmoid	BT20 omipalisib 0 1 72	8	2.078	0.00617	-0.729	0.985	0.0283	-0.739	0.596	0.97	2.83e-05	NA	0.00781	0.0157	0.306	0.00685	0.0597	0.96	0.988	1.57e-06	NA
BT-20	Omipalisib	2	72	sigmoid	sigmoid	BT20 omipalisib 0 2 72	8	1.717	0.00324	-0.799	1.1	0.00361	-0.354	4.99	0.808	0.00704	NA	0.00518	0.0194	0.291	0.00429	0.111	1.34	0.968	3.16e-05	NA
BT-20	Omipalisib	3	72	sigmoid	sigmoid	BT20 omipalisib 0 3 72	8	2.586	0.00689	-0.587	0.893	0.044	-0.714	0.478	0.958	7.32e-05	NA	0.00572	0.017	0.281	0.00491	0.0669	0.945	0.983	4.7e-06	NA
BT-20	PI103	1	72	sigmoid	sigmoid	BT20 PI-103 0 1 72	8	1.924	0.646	-0.0114	0.16	0.659	-0.0268	2.6	0.978	1.1e-05	NA	0.753	0.258	0.883	0.579	0.252	2.68	0.964	4.79e-05	NA
BT-20	PI103	2	72	sigmoid	sigmoid	BT20 PI-103 0 2 72	8	1.725	0.235	-0.21	0.388	0.289	-0.212	1.7	0.975	1.64e-05	NA	0.319	0.202	0.721	0.239	0.205	1.81	0.961	5.88e-05	NA
BT-20	PI103	3	72	sigmoid	sigmoid	BT20 PI-103 0 3 72	8	2.496	0.373	0.0139	0.282	0.387	-0.0286	1.52	0.994	1.99e-07	NA	0.359	0.183	0.735	0.279	0.162	1.56	0.988	1.71e-06	NA
BT-20	Pictilisib	1	72	sigmoid	sigmoid	BT20 pictilisib 0 1 72	8	2.085	1.25	0.163	0.177	5.0	-1.0	0.791	0.994	1.75e-07	NA	1.52	0.323	0.838	1.52	0.0	0.865	0.989	1.22e-06	NA
BT-20	Pictilisib	2	72	sigmoid	sigmoid	BT20 pictilisib 0 2 72	8	1.746	0.308	-0.0521	0.379	2.35	-1.0	0.54	0.791	0.00908	NA	0.634	0.272	0.712	0.634	0.0	0.6	0.716	0.0229	NA
BT-20	Pictilisib	3	72	sigmoid	sigmoid	BT20 pictilisib 0 3 72	8	2.566	0.839	0.172	0.22	0.914	-0.0483	1.09	0.954	9.59e-05	NA	0.843	0.254	0.768	0.809	0.0179	0.898	0.918	0.000551	NA
BT-20	PIK-93	1	72	sigmoid	sigmoid	BT20 PIK-93 0 1 72	8	2.025	2.65	0.406	0.0864	6.54	-1.0	1.22	0.993	3.89e-07	NA	3.15	0.49	0.92	3.15	0.0	1.31	0.989	1.33e-06	NA
BT-20	PIK-93	2	72	sigmoid	sigmoid	BT20 PIK-93 0 2 72	8	1.798	0.792	0.155	0.286	14.1	-1.0	0.382	0.81	0.00687	NA	2.8	0.373	0.764	2.8	0.0	0.344	0.77	0.0121	NA
BT-20	PIK-93	3	72	sigmoid	sigmoid	BT20 PIK-93 0 3 72	8	2.532	2.65	0.419	0.097	7.54	-1.0	1.05	0.982	5.47e-06	NA	2.5	0.42	0.892	2.5	0.0	1.17	0.971	2.45e-05	NA
BT-20	XL147	1	72	flat	flat	BT20 pilaralisib 0 1 72	8	2.128	Inf	0.815	0.048	0.0	0.815	0.01	0.411	0.205	0.939	Inf	0.813	0.95	0.0	0.813	0.01	0.383	0.234	0.937
BT-20	XL147	2	72	flat	flat	BT20 pilaralisib 0 2 72	8	1.784	Inf	0.759	0.073	0.0	0.759	0.01	-0.0058	1.0	0.907	Inf	0.796	0.937	0.0	0.796	0.01	-0.00637	1.0	0.92

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)