Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-20 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | BT20 WYE-132 0 1 72 | 8 | 2.067 | 0.0893 | 0.289 | 0.402 | 0.0435 | 0.256 | 1.0 | 0.987 | 2.28e-06 | NA | 0.154 | 0.403 | 0.647 | 0.0353 | 0.375 | 0.941 | 0.985 | 3.56e-06 | NA |
BT-20 | Alpelisib | 1 | 72 | sigmoid | sigmoid | BT20 alpelisib 0 1 72 | 8 | 2.077 | 1.14 | 0.046 | 0.196 | 3.52 | -1.0 | 0.977 | 0.966 | 4.1e-05 | NA | 1.32 | 0.26 | 0.825 | 1.32 | 0.0 | 1.13 | 0.942 | 0.000194 | NA |
BT-20 | Omipalisib | 1 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 1 72 | 8 | 2.078 | 0.00617 | -0.729 | 0.985 | 0.0283 | -0.739 | 0.596 | 0.97 | 2.83e-05 | NA | 0.00781 | 0.0157 | 0.306 | 0.00685 | 0.0597 | 0.96 | 0.988 | 1.57e-06 | NA |
Hs 578T | Omipalisib | 1 | sigmoid | sigmoid | Hs578T omipalisib 1 | 8 | 2.079 | 0.00552 | -0.546 | 0.842 | 0.17 | -1.0 | 0.321 | 0.98 | 8.1e-06 | NA | 0.0079 | 0.0459 | 0.351 | 0.0079 | 0.0 | 0.369 | 0.984 | 4.12e-06 | NA | |
BT-20 | Pictilisib | 1 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 1 72 | 8 | 2.085 | 1.25 | 0.163 | 0.177 | 5.0 | -1.0 | 0.791 | 0.994 | 1.75e-07 | NA | 1.52 | 0.323 | 0.838 | 1.52 | 0.0 | 0.865 | 0.989 | 1.22e-06 | NA |
HCC38 | Alpelisib | 2 | 72 | flat | flat | HCC38 alpelisib 0 2 72 | 8 | 2.086 | Inf | 0.848 | 0.0559 | 0.0 | 0.848 | 0.01 | -0.0371 | 1.0 | 0.931 | Inf | 0.848 | 0.944 | 0.0 | 0.848 | 0.01 | -0.0359 | 1.0 | 0.932 |
BT-20 | MK2206 | 1 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 1 72 | 8 | 2.089 | Inf | 0.732 | 0.102 | 4.16 | 0.529 | 0.345 | 0.671 | 0.0357 | NA | Inf | 0.741 | 0.898 | 4.14 | 0.538 | 0.337 | 0.676 | 0.034 | NA |
HCC38 | PI103 | 2 | 72 | sigmoid | sigmoid | HCC38 PI-103 0 2 72 | 8 | 2.094 | 0.856 | 0.226 | 0.167 | 0.672 | 0.135 | 1.3 | 0.986 | 2.7e-06 | NA | 1.04 | 0.359 | 0.851 | 0.488 | 0.33 | 1.43 | 0.981 | 6.52e-06 | NA |
Hs 578T | Alpelisib | 1 | sigmoid | sigmoid | Hs578T alpelisib 1 | 8 | 2.097 | 2.3 | 0.449 | 0.205 | 42.0 | -1.0 | 0.378 | 0.954 | 9.56e-05 | NA | 3.9 | 0.508 | 0.803 | 3.9 | 0.0 | 0.401 | 0.94 | 0.000216 | NA | |
BT-20 | Sirolimus | 1 | 72 | flat | flat | BT20 rapamycin 0 1 72 | 8 | 2.100 | Inf | 0.568 | 0.431 | 0.0 | 0.568 | 0.01 | -9.89 | 1.0 | 0.568 | Inf | 0.6 | 0.601 | 0.0 | 0.6 | 0.01 | -13.0 | 1.0 | 0.6 |
HCC38 | Sirolimus | 2 | 72 | flat | flat | HCC38 rapamycin 0 2 72 | 8 | 2.106 | Inf | 0.588 | 0.371 | 0.0 | 0.588 | 0.01 | 0.496 | 0.128 | 0.629 | Inf | 0.616 | 0.65 | 0.0 | 0.616 | 0.01 | 0.246 | 0.429 | 0.649 |
HCC38 | PIK-93 | 2 | 72 | sigmoid | sigmoid | HCC38 PIK-93 0 2 72 | 8 | 2.107 | 31.9 | 0.661 | 0.0151 | 2.16 | 0.497 | 1.86 | 0.922 | 0.000468 | NA | Inf | 0.676 | 0.987 | 1.97 | 0.545 | 1.87 | 0.907 | 0.000813 | NA |
HCC38 | Pictilisib | 2 | 72 | sigmoid | sigmoid | HCC38 pictilisib 0 2 72 | 8 | 2.112 | Inf | 0.622 | 0.0838 | 0.644 | 0.58 | 1.32 | 0.933 | 0.000298 | NA | Inf | 0.642 | 0.918 | 0.568 | 0.612 | 1.36 | 0.922 | 0.000475 | NA |
BT-20 | CAL-101 | 1 | 72 | flat | flat | BT20 idelalisib 0 1 72 | 8 | 2.112 | Inf | 0.869 | 0.0546 | 0.0 | 0.869 | 0.01 | 0.0807 | 0.777 | 0.938 | Inf | 0.867 | 0.943 | 0.0 | 0.867 | 0.01 | 0.0778 | 0.784 | 0.936 |
HCC38 | TGX221 | 2 | 72 | sigmoid | sigmoid | HCC38 TGX-221 0 2 72 | 8 | 2.116 | Inf | 0.908 | 0.0281 | 4.57 | 0.803 | 0.501 | 0.711 | 0.0242 | NA | Inf | 0.905 | 0.971 | 4.56 | 0.797 | 0.497 | 0.705 | 0.0256 | NA |
BT-20 | AZD8055 | 1 | 72 | sigmoid | sigmoid | BT20 AZD8055 0 1 72 | 8 | 2.117 | 0.0548 | 0.243 | 0.465 | 0.0266 | 0.213 | 0.768 | 0.984 | 4.08e-06 | NA | 0.0937 | 0.365 | 0.589 | 0.0198 | 0.335 | 0.713 | 0.982 | 5.4e-06 | NA |
HCC38 | Dactolisib | 2 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 2 72 | 8 | 2.120 | 0.0118 | -0.0557 | 0.668 | 0.0118 | -0.00134 | 0.785 | 0.98 | 7.61e-06 | NA | 0.0145 | 0.204 | 0.447 | 0.00701 | 0.245 | 0.927 | 0.988 | 1.88e-06 | NA |
HCC38 | Omipalisib | 2 | 72 | sigmoid | sigmoid | HCC38 omipalisib 0 2 72 | 8 | 2.124 | 0.0404 | -0.47 | 0.634 | 0.45 | -1.0 | 0.456 | 0.979 | 9.71e-06 | NA | 0.0507 | 0.0595 | 0.494 | 0.0507 | 0.0 | 0.556 | 0.96 | 6.44e-05 | NA |
BT-20 | KIN001-244 | 1 | 72 | flat | flat | BT20 KIN001-244 0 1 72 | 8 | 2.125 | Inf | 0.911 | 0.0401 | 0.0 | 0.911 | 0.01 | -0.00641 | 1.0 | 0.957 | Inf | 0.908 | 0.958 | 0.0 | 0.908 | 0.01 | -0.00745 | 1.0 | 0.955 |
BT-20 | XL147 | 1 | 72 | flat | flat | BT20 pilaralisib 0 1 72 | 8 | 2.128 | Inf | 0.815 | 0.048 | 0.0 | 0.815 | 0.01 | 0.411 | 0.205 | 0.939 | Inf | 0.813 | 0.95 | 0.0 | 0.813 | 0.01 | 0.383 | 0.234 | 0.937 |
HCC38 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 2 72 | 8 | 2.128 | 0.0616 | 0.16 | 0.467 | 0.045 | 0.124 | 0.912 | 0.993 | 3.13e-07 | NA | 0.0875 | 0.314 | 0.594 | 0.0332 | 0.284 | 0.869 | 0.991 | 6.5e-07 | NA |
BT-20 | Buparlisib | 1 | 72 | sigmoid | sigmoid | BT20 buparlisib 0 1 72 | 8 | 2.131 | 0.598 | -0.394 | 0.285 | 1.19 | -0.763 | 1.35 | 0.992 | 4.68e-07 | NA | 0.663 | 0.0784 | 0.766 | 0.663 | 0.0 | 1.49 | 0.981 | 7.06e-06 | NA |
HCC38 | AZD-6482 | 2 | 72 | sigmoid | sigmoid | HCC38 AZD6482 0 2 72 | 8 | 2.132 | Inf | 0.898 | 0.0351 | 4.71 | 0.773 | 0.497 | 0.824 | 0.0055 | NA | Inf | 0.894 | 0.963 | 4.7 | 0.765 | 0.492 | 0.82 | 0.00588 | NA |
HCC38 | Trametinib | 2 | 72 | sigmoid | sigmoid | HCC38 trametinib 0 2 72 | 8 | 2.133 | 0.219 | 0.267 | 0.389 | 0.222 | -0.00324 | 0.424 | 0.987 | 2.39e-06 | NA | 0.391 | 0.377 | 0.644 | 0.127 | 0.183 | 0.404 | 0.988 | 1.91e-06 | NA |
HCC38 | Torin1 | 2 | 72 | sigmoid | sigmoid | HCC38 Torin1 0 2 72 | 8 | 2.136 | 0.0241 | 0.0393 | 0.573 | 0.0203 | 0.0651 | 0.82 | 0.995 | 1.24e-07 | NA | 0.0309 | 0.247 | 0.512 | 0.013 | 0.267 | 0.88 | 0.996 | 4.87e-08 | NA |