Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 MK2206 2 72
sigmoid
sigmoid
HCC70 MK-2206 0 2 72
 8 1.690
0.446
0.244
0.2
0.301
0.226
1.53
0.973
1.92e-05
NA
1.03
0.448
0.851
0.266
0.44
1.56
0.965
4.11e-05
NA
HCC38 PI103 2 72
sigmoid
sigmoid
HCC38 PI-103 0 2 72
 8 2.094
0.856
0.226
0.167
0.672
0.135
1.3
0.986
2.7e-06
NA
1.04
0.359
0.851
0.488
0.33
1.43
0.981
6.52e-06
NA
BT-549 PIK-93 2 72
sigmoid
sigmoid
BT549 PIK-93 0 2 72
 8 1.983
7.03
0.687
0.0641
29.9
-1.0
0.759
0.956
8.81e-05
NA
10.4
0.713
0.939
10.4
0.0
0.788
0.949
0.000136
NA
HCC1806 Sirolimus 1 72
sigmoid
sigmoid
HCC1806 rapamycin 0 1 72
 8 2.796
1.35
0.775
0.187
0.00019
0.706
0.1
0.661
0.039
NA
1.05
0.717
0.76
1e-05
0.657
0.1
0.68
0.0328
NA
HCC1806 Sirolimus 3 72
sigmoid
sigmoid
HCC1806 rapamycin 0 3 72
 8 3.249
0.223
0.805
0.162
0.000183
0.746
0.1
0.663
0.0382
NA
1.05
0.717
0.76
1e-05
0.657
0.1
0.68
0.0328
NA
HCC70 PIK-93 1 72
sigmoid
sigmoid
HCC70 PIK-93 0 1 72
 8 1.442
3.47
0.482
0.137
18.6
-1.0
0.656
0.774
0.0116
NA
10.7
0.649
0.904
10.7
0.0
0.632
0.746
0.0163
NA
HCC38 Buparlisib 3 72
sigmoid
sigmoid
HCC38 buparlisib 0 3 72
 8 1.431
0.674
-0.377
0.272
1.67
-1.0
1.21
0.991
6.94e-07
NA
1.11
0.188
0.824
1.11
0.0
1.32
0.987
2.46e-06
NA
BT-20 Alpelisib 3 72
sigmoid
sigmoid
BT20 alpelisib 0 3 72
 8 2.541
1.21
0.199
0.21
5.83
-1.0
0.697
0.881
0.00167
NA
1.12
0.272
0.775
1.12
0.0
0.764
0.791
0.00916
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
BT-549 ZSTK474 1 72
sigmoid
sigmoid
BT549 ZSTK474 0 1 72
 8 1.861
0.58
0.213
0.256
0.583
-0.00205
0.771
0.992
5.43e-07
NA
1.12
0.394
0.788
0.428
0.261
0.767
0.989
1.49e-06
NA
HCC70 AZD-6482 3 72
sigmoid
sigmoid
HCC70 AZD6482 0 3 72
 8 2.532
1.43
0.435
0.247
0.421
0.226
0.492
0.983
4.63e-06
NA
1.13
0.431
0.729
0.208
0.286
0.5
0.982
6.2e-06
NA
HCC1806 Pictilisib 3 72
sigmoid
sigmoid
HCC1806 pictilisib 0 3 72
 8 3.234
14.1
0.818
0.0423
52.2
-0.98
0.831
0.814
0.00649
NA
11.3
0.734
0.935
11.3
0.0
0.849
0.773
0.0116
NA
HCC1806 Pictilisib 1 72
sigmoid
sigmoid
HCC1806 pictilisib 0 1 72
 8 2.782
11.7
0.79
0.049
43.7
-1.0
0.831
0.811
0.00677
NA
11.3
0.734
0.935
11.3
0.0
0.849
0.773
0.0116
NA
HCC1806 Pictilisib 2 72
sigmoid
sigmoid
HCC1806 pictilisib 0 2 72
 8 2.866
12.1
0.796
0.0476
45.4
-1.0
0.831
0.811
0.00671
NA
11.3
0.734
0.935
11.3
0.0
0.849
0.773
0.0116
NA
BT-549 AZD-6482 3 72
sigmoid
sigmoid
BT549 AZD6482 0 3 72
 8 1.744
8.87
0.616
0.0979
2.2
0.324
0.749
0.993
2.93e-07
NA
115.0
0.69
0.918
1.91
0.476
0.744
0.993
4.19e-07
NA
HCC70 AZD-6482 2 72
sigmoid
sigmoid
HCC70 AZD6482 0 2 72
 8 1.772
0.267
0.256
0.366
0.237
0.0255
0.43
0.987
2.27e-06
NA
1.16
0.438
0.706
0.133
0.306
0.437
0.986
3.03e-06
NA
BT-549 CAL-101 3 72
sigmoid
sigmoid
BT549 idelalisib 0 3 72
 8 1.770
43.0
0.79
0.0687
320.0
-0.664
0.421
0.862
0.00261
NA
118.0
0.822
0.941
118.0
0.0
0.425
0.854
0.00309
NA
HCC70 Alpelisib 1 72
sigmoid
sigmoid
HCC70 alpelisib 0 1 72
 8 1.383
4.4
0.574
0.105
20.4
-1.0
0.717
0.78
0.0106
NA
11.9
0.718
0.929
11.9
0.0
0.732
0.768
0.0124
NA
BT-549 BX-912 1 72
sigmoid
sigmoid
BT549 BX-912 0 1 72
 8 1.839
0.909
0.247
0.157
0.742
0.24
3.23
0.992
5.95e-07
NA
1.2
0.419
0.872
0.698
0.415
3.25
0.988
1.54e-06
NA
HCC38 Buparlisib 1 72
sigmoid
sigmoid
HCC38 buparlisib 0 1 72
 8 1.738
0.912
-0.226
0.194
1.46
-0.57
1.62
0.999
9.48e-10
NA
1.2
0.192
0.858
1.12
0.0495
1.66
0.998
4.36e-09
NA
HCC70 Pictilisib 2 72
sigmoid
sigmoid
HCC70 pictilisib 0 2 72
 8 1.783
0.811
0.124
0.189
0.858
-0.0372
1.27
0.973
2.08e-05
NA
1.25
0.358
0.852
0.678
0.278
1.32
0.963
5.09e-05
NA
HCC70 Sirolimus 1 72
sigmoid
sigmoid
HCC70 rapamycin 0 1 72
 8 1.416
37.6
0.533
0.397
0.00426
0.298
0.1
0.742
0.0172
NA
125000000.0
0.687
0.732
0.00186
0.541
0.1
0.74
0.0175
NA
HCC70 BX-912 3 72
sigmoid
sigmoid
HCC70 BX-912 0 3 72
 8 2.465
1.26
0.174
0.0739
1.16
0.168
5.0
0.988
1.75e-06
NA
1.26
0.269
0.935
1.08
0.265
5.0
0.977
1.15e-05
NA
BT-549 BX-912 2 72
sigmoid
sigmoid
BT549 BX-912 0 2 72
 8 1.948
1.04
0.33
0.126
0.84
0.329
5.0
0.99
1.01e-06
NA
1.28
0.452
0.892
0.808
0.451
5.0
0.987
2.4e-06
NA
HCC70 Pictilisib 3 72
sigmoid
sigmoid
HCC70 pictilisib 0 3 72
 8 2.450
1.32
0.305
0.102
0.938
0.225
1.76
0.983
4.73e-06
NA
1.28
0.351
0.901
0.766
0.303
1.81
0.973
2.06e-05
NA