Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T MK2206 3
sigmoid
sigmoid
Hs578T MK-2206 3
 8 2.883
Inf
0.737
0.0965
0.144
0.768
1.94
0.962
5.58e-05
NA
Inf
0.666
0.873
0.135
0.7
1.85
0.967
3.69e-05
NA
Hs 578T Sirolimus 2
flat
flat
Hs578T rapamycin 2
 8 2.536
Inf
0.623
0.341
0.0
0.623
0.01
0.16
0.593
0.66
Inf
0.589
0.623
0.0
0.589
0.01
-0.232
1.0
0.624
Hs 578T Sirolimus 3
flat
flat
Hs578T rapamycin 3
 8 2.836
Inf
0.675
0.309
0.0
0.675
0.01
-1.79
1.0
0.691
Inf
0.604
0.621
0.0
0.604
0.01
-3.02
1.0
0.621
Hs 578T TGX221 2
sigmoid
sigmoid
Hs578T TGX-221 2
 8 2.462
Inf
0.816
0.0307
0.904
0.781
1.29
0.964
4.56e-05
NA
Inf
0.789
0.964
0.834
0.754
1.3
0.96
6.63e-05
NA
Hs 578T XL147 1
flat
flat
Hs578T pilaralisib 1
 8 2.013
Inf
0.967
0.00411
0.0
0.967
0.01
0.193
0.525
0.991
Inf
0.967
0.996
0.0
0.967
0.01
0.196
0.519
0.991
Hs 578T XL147 2
flat
flat
Hs578T pilaralisib 2
 8 2.509
Inf
0.976
0.000255
0.0
0.976
0.01
0.435
0.181
0.997
Inf
0.97
1.0
0.0
0.97
0.01
0.432
0.183
0.996
Hs 578T XL147 3
flat
flat
Hs578T pilaralisib 3
 8 2.879
Inf
0.971
-0.00618
0.0
0.971
0.01
0.331
0.299
1.0
Inf
0.959
1.01
0.0
0.959
0.01
0.319
0.315
1.0