Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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Hs 578T | KIN001-244 | 2 | sigmoid | sigmoid | Hs578T KIN001-244 2 | 8 | 2.505 | Inf | 0.819 | 0.0357 | 4.8 | 0.531 | 1.14 | 0.891 | 0.0013 | NA | 44.3 | 0.788 | 0.957 | 4.79 | 0.457 | 1.1 | 0.878 | 0.0018 | NA | |
BT-20 | AS605240 | 2 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 2 72 | 8 | 1.846 | 4509270.0 | 0.729 | 0.203 | 320.0 | 0.31 | 0.101 | 0.845 | 0.00373 | NA | 4.4e+12 | 0.764 | 0.821 | 56.5 | 0.46 | 0.101 | 0.843 | 0.00388 | NA |
HCC38 | AS605240 | 2 | 72 | sigmoid | sigmoid | HCC38 AS-605240 0 2 72 | 8 | 2.200 | 17.4 | 0.642 | 0.114 | 4.07 | 0.256 | 0.493 | 0.936 | 0.000265 | NA | 46.2 | 0.648 | 0.882 | 1.68 | 0.411 | 0.522 | 0.929 | 0.000356 | NA |
HCC1806 | PIK-93 | 2 | 72 | sigmoid | sigmoid | HCC1806 PIK-93 0 2 72 | 8 | 2.838 | 41.1 | 0.857 | 0.038 | 265.0 | -1.0 | 0.59 | 0.858 | 0.00286 | NA | 46.6 | 0.811 | 0.948 | 46.6 | 0.0 | 0.57 | 0.84 | 0.00406 | NA |
HCC1806 | PIK-93 | 3 | 72 | sigmoid | sigmoid | HCC1806 PIK-93 0 3 72 | 8 | 3.206 | 56.0 | 0.873 | 0.0337 | 320.0 | -0.872 | 0.579 | 0.859 | 0.00279 | NA | 46.6 | 0.811 | 0.948 | 46.6 | 0.0 | 0.57 | 0.84 | 0.00406 | NA |
HCC1806 | PIK-93 | 1 | 72 | sigmoid | sigmoid | HCC1806 PIK-93 0 1 72 | 8 | 2.753 | 44.0 | 0.853 | 0.0391 | 304.0 | -1.0 | 0.568 | 0.858 | 0.00285 | NA | 46.6 | 0.811 | 0.948 | 46.6 | 0.0 | 0.57 | 0.84 | 0.00406 | NA |
BT-549 | TGX221 | 3 | 72 | sigmoid | sigmoid | BT549 TGX-221 0 3 72 | 8 | 1.768 | 93790.0 | 0.805 | 0.0889 | 320.0 | 0.356 | 0.22 | 0.707 | 0.0251 | NA | 49050766.0 | 0.834 | 0.923 | 320.0 | 0.461 | 0.214 | 0.703 | 0.0263 | NA |
Hs 578T | KIN001-244 | 3 | sigmoid | sigmoid | Hs578T KIN001-244 3 | 8 | 2.888 | Inf | 0.866 | 0.00909 | 5.05 | 0.617 | 1.35 | 0.858 | 0.00289 | NA | 50.0 | 0.818 | 0.988 | 5.2 | 0.474 | 1.31 | 0.842 | 0.00391 | NA | |
BT-549 | Sirolimus | 1 | 72 | sigmoid | sigmoid | BT549 rapamycin 0 1 72 | 8 | 1.817 | 3.62 | 0.51 | 0.438 | 0.000148 | 0.318 | 0.1 | 0.87 | 0.00218 | NA | 506850.0 | 0.6 | 0.638 | 8.82e-05 | 0.447 | 0.1 | 0.8 | 0.00802 | NA |
BT-549 | Pictilisib | 1 | 72 | sigmoid | sigmoid | BT549 pictilisib 0 1 72 | 8 | 1.772 | 2.08 | 0.415 | 0.117 | 1.42 | 0.154 | 0.959 | 0.987 | 2.26e-06 | NA | 5.12 | 0.541 | 0.904 | 1.06 | 0.396 | 0.995 | 0.985 | 3.49e-06 | NA |
Hs 578T | AZD-6482 | 3 | sigmoid | sigmoid | Hs578T AZD6482 3 | 8 | 2.832 | 6.09 | 0.667 | 0.0547 | 24.1 | -1.0 | 0.799 | 0.989 | 1.5e-06 | NA | 5.12 | 0.597 | 0.93 | 5.12 | 0.0 | 0.861 | 0.985 | 3.33e-06 | NA | |
HCC70 | Torin1 | 3 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 3 72 | 8 | 2.415 | 3.74 | 0.495 | 0.279 | 0.0352 | 0.496 | 1.02 | 0.994 | 2.6e-07 | NA | 5.73 | 0.495 | 0.709 | 0.0284 | 0.498 | 1.06 | 0.994 | 2.26e-07 | NA |
HCC38 | Everolimus | 3 | 72 | sigmoid | sigmoid | HCC38 everolimus 0 3 72 | 8 | 1.437 | 5.11 | 0.511 | 0.429 | 0.000567 | 0.299 | 0.1 | 0.934 | 0.000284 | NA | 573000000.0 | 0.668 | 0.707 | 0.000349 | 0.53 | 0.1 | 0.932 | 0.000308 | NA |
Hs 578T | AS605240 | 3 | sigmoid | sigmoid | Hs578T AS-605240 3 | 8 | 2.856 | 63.8 | 0.588 | 0.0965 | 0.826 | 0.494 | 1.03 | 0.983 | 4.89e-06 | NA | 5.75 | 0.518 | 0.879 | 0.552 | 0.465 | 1.14 | 0.981 | 6.87e-06 | NA | |
HCC70 | TGX221 | 2 | 72 | sigmoid | sigmoid | HCC70 TGX-221 0 2 72 | 8 | 1.786 | 1.77 | 0.467 | 0.233 | 0.531 | 0.227 | 0.503 | 0.948 | 0.000139 | NA | 5.85 | 0.575 | 0.806 | 3.44 | 0.0897 | 0.372 | 0.937 | 0.000249 | NA |
HCC70 | PIK-93 | 2 | 72 | sigmoid | sigmoid | HCC70 PIK-93 0 2 72 | 8 | 1.705 | 4.34 | 0.647 | 0.0132 | 9.3 | -1.0 | 1.44 | 0.888 | 0.0014 | NA | 6.01 | 0.718 | 0.991 | 6.01 | 0.0 | 1.49 | 0.872 | 0.00208 | NA |
HCC38 | MK2206 | 1 | 72 | sigmoid | sigmoid | HCC38 MK-2206 0 1 72 | 8 | 1.789 | 19.4 | 0.698 | 0.0995 | 320.0 | -0.949 | 0.38 | 0.956 | 8.33e-05 | NA | 61.8 | 0.746 | 0.914 | 61.8 | 0.0 | 0.386 | 0.951 | 0.000115 | NA |
Hs 578T | AZD-6482 | 2 | sigmoid | sigmoid | Hs578T AZD6482 2 | 8 | 2.508 | 6.35 | 0.602 | 0.121 | 74.8 | -1.0 | 0.445 | 0.998 | 1.12e-08 | NA | 6.4 | 0.573 | 0.86 | 6.4 | 0.0 | 0.475 | 0.996 | 6.36e-08 | NA | |
HCC38 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | HCC38 ZSTK474 0 3 72 | 8 | 1.458 | 2.06 | 0.398 | 0.146 | 5.06 | -0.41 | 0.665 | 0.989 | 1.23e-06 | NA | 6.44 | 0.593 | 0.898 | 3.35 | 0.179 | 0.678 | 0.988 | 1.64e-06 | NA |
BT-549 | PIK-93 | 3 | 72 | sigmoid | sigmoid | BT549 PIK-93 0 3 72 | 8 | 1.807 | 20.1 | 0.719 | 0.0848 | 231.0 | -1.0 | 0.45 | 0.716 | 0.0229 | NA | 67.9 | 0.761 | 0.925 | 67.9 | 0.0 | 0.431 | 0.686 | 0.0309 | NA |
HCC38 | Sirolimus | 3 | 72 | sigmoid | sigmoid | HCC38 rapamycin 0 3 72 | 8 | 1.420 | 86.3 | 0.535 | 0.403 | 0.000236 | 0.361 | 0.1 | 0.901 | 0.000982 | NA | 75575.0 | 0.687 | 0.727 | 0.000198 | 0.569 | 0.1 | 0.889 | 0.00136 | NA |
HCC70 | AS605240 | 2 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 2 72 | 8 | 1.771 | 6.13 | 0.558 | 0.126 | 1.21 | 0.339 | 0.698 | 0.981 | 7.24e-06 | NA | 785.0 | 0.643 | 0.894 | 0.946 | 0.496 | 0.708 | 0.978 | 1.04e-05 | NA |
HCC38 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | HCC38 ZSTK474 0 1 72 | 8 | 1.742 | 2.47 | 0.456 | 0.132 | 1.34 | 0.202 | 0.843 | 0.991 | 7.12e-07 | NA | 9.02 | 0.575 | 0.893 | 1.0 | 0.426 | 0.869 | 0.99 | 1.01e-06 | NA |
Hs 578T | Sirolimus | 1 | sigmoid | sigmoid | Hs578T rapamycin 1 | 8 | 2.013 | 110643.0 | 0.587 | 0.358 | 0.000237 | 0.432 | 0.1 | 0.879 | 0.00178 | NA | 9.61e+11 | 0.628 | 0.672 | 0.000175 | 0.487 | 0.1 | 0.851 | 0.00332 | NA | |
HCC38 | PIK-93 | 1 | 72 | sigmoid | sigmoid | HCC38 PIK-93 0 1 72 | 8 | 1.741 | 5.24 | 0.61 | 0.0782 | 24.5 | -1.0 | 0.713 | 0.982 | 6.07e-06 | NA | 9.93 | 0.686 | 0.935 | 9.93 | 0.0 | 0.729 | 0.979 | 9.08e-06 | NA |