Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T PI103 1
sigmoid
sigmoid
Hs578T PI-103 1
 8 2.062
0.131
-0.0743
0.433
0.182
-0.173
0.898
0.996
4.43e-08
NA
0.175
0.204
0.643
0.117
0.152
0.898
0.995
1.02e-07
NA
HCC1806 Dactolisib 1 72
sigmoid
sigmoid
HCC1806 dactolisib 0 1 72
 8 2.743
0.135
-0.0744
0.444
0.391
-0.425
0.577
0.986
2.81e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
BT-549 WYE-125132 2 72
sigmoid
sigmoid
BT549 WYE-132 0 2 72
 8 1.780
0.0329
0.0784
0.528
0.0287
0.0811
1.29
0.988
1.59e-06
NA
0.0545
0.333
0.604
0.0236
0.337
1.34
0.986
2.87e-06
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
BT-20 MK2206 2 72
sigmoid
sigmoid
BT20 MK-2206 0 2 72
 8 1.739
0.823
0.0896
0.246
4.34
-1.0
0.661
0.965
4.36e-05
NA
1.47
0.348
0.806
1.47
0.0
0.715
0.947
0.000145
NA
BT-549 PI103 1 72
sigmoid
sigmoid
BT549 PI-103 0 1 72
 8 1.795
0.206
0.0898
0.34
0.185
0.0628
1.25
0.997
2.96e-08
NA
0.348
0.336
0.737
0.155
0.318
1.25
0.996
8.76e-08
NA
HCC1806 Torin2 3 72
sigmoid
sigmoid
HCC1806 Torin2 0 3 72
 8 3.212
0.0678
-0.0927
0.522
0.0798
-0.12
1.32
0.996
6.56e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
HCC70 Pictilisib 1 72
sigmoid
sigmoid
HCC70 pictilisib 0 1 72
 8 1.409
0.408
-0.099
0.284
0.578
-0.245
1.14
0.996
7.62e-08
NA
0.888
0.325
0.816
0.477
0.261
1.19
0.995
1.2e-07
NA
BT-20 Alpelisib 2 72
sigmoid
sigmoid
BT20 alpelisib 0 2 72
 8 1.692
0.253
-0.0994
0.405
2.25
-1.0
0.503
0.835
0.00451
NA
0.612
0.259
0.698
0.612
0.0
0.507
0.764
0.0131
NA
BT-20 Torin1 1 72
sigmoid
sigmoid
BT20 Torin1 0 1 72
 8 2.022
0.0383
-0.105
0.566
0.0658
-0.179
0.565
0.991
7.45e-07
NA
0.0591
0.197
0.536
0.0286
0.182
0.624
0.994
2.54e-07
NA
Hs 578T Omipalisib 3
sigmoid
sigmoid
Hs578T omipalisib 3
 8 2.869
0.0255
-0.107
0.615
0.0533
-0.22
0.494
0.99
8.79e-07
NA
0.0145
0.0989
0.392
0.0102
0.0968
0.62
0.993
3.4e-07
NA
BT-549 WYE-125132 1 72
sigmoid
sigmoid
BT549 WYE-132 0 1 72
 8 1.787
0.0317
0.11
0.542
0.026
0.0962
1.09
0.996
5.11e-08
NA
0.062
0.349
0.589
0.0213
0.338
1.05
0.997
3.82e-08
NA
BT-549 GDC-0980 1 72
sigmoid
sigmoid
BT549 apitolisib 0 1 72
 8 1.781
0.19
0.113
0.333
0.16
0.1
1.27
0.999
4.05e-10
NA
0.328
0.352
0.744
0.132
0.347
1.31
0.999
7.05e-10
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
HCC38 PI103 3 72
sigmoid
sigmoid
HCC38 PI-103 0 3 72
 8 1.481
1.26
0.114
0.168
3.16
-0.762
1.01
0.986
2.53e-06
NA
2.34
0.42
0.884
2.34
0.0
1.03
0.983
4.94e-06
NA
BT-20 GDC-0980 3 72
sigmoid
sigmoid
BT20 apitolisib 0 3 72
 8 2.502
0.0976
-0.115
0.437
0.107
-0.0716
1.53
0.994
2.41e-07
NA
0.0894
0.13
0.62
0.0732
0.163
1.96
0.996
6.83e-08
NA
HCC70 Pictilisib 2 72
sigmoid
sigmoid
HCC70 pictilisib 0 2 72
 8 1.783
0.811
0.124
0.189
0.858
-0.0372
1.27
0.973
2.08e-05
NA
1.25
0.358
0.852
0.678
0.278
1.32
0.963
5.09e-05
NA
HCC38 Trametinib 3 72
sigmoid
sigmoid
HCC38 trametinib 0 3 72
 8 1.486
0.229
0.132
0.342
0.19
0.108
1.3
0.969
2.85e-05
NA
0.689
0.429
0.766
0.176
0.409
1.25
0.962
5.31e-05
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
BT-549 ZSTK474 3 72
sigmoid
sigmoid
BT549 ZSTK474 0 3 72
 8 1.776
0.504
0.139
0.267
0.616
-0.0912
0.836
0.996
7.06e-08
NA
0.994
0.368
0.789
0.489
0.218
0.808
0.995
9.19e-08
NA
BT-549 AZD8055 2 72
sigmoid
sigmoid
BT549 AZD8055 0 2 72
 8 1.848
0.0373
0.14
0.506
0.0287
0.138
1.23
0.994
2.1e-07
NA
0.0653
0.354
0.605
0.0239
0.35
1.2
0.995
1.39e-07
NA
HCC1806 BX-912 1 72
sigmoid
sigmoid
HCC1806 BX-912 0 1 72
 8 2.740
0.971
0.14
0.143
0.885
0.121
2.99
0.998
3.45e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC38 WYE-125132 1 72
sigmoid
sigmoid
HCC38 WYE-132 0 1 72
 8 1.708
0.0604
0.142
0.447
0.0481
0.134
1.36
0.997
3.43e-08
NA
0.115
0.384
0.669
0.0413
0.381
1.4
0.996
6.46e-08
NA
BT-20 WYE-125132 2 72
sigmoid
sigmoid
BT20 WYE-132 0 2 72
 8 2.053
0.012
0.142
0.633
0.00936
0.072
0.621
0.909
0.000752
NA
0.0232
0.316
0.475
0.00613
0.255
0.536
0.894
0.00119
NA
BT-549 ZSTK474 2 72
sigmoid
sigmoid
BT549 ZSTK474 0 2 72
 8 1.962
0.628
0.144
0.245
0.841
-0.139
0.84
0.995
1.29e-07
NA
0.958
0.334
0.791
0.595
0.163
0.828
0.992
4.28e-07
NA