Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-549	WYE-125132	3	72	sigmoid	sigmoid	BT549 WYE-132 0 3 72	8	1.662	0.0271	0.0265	0.567	0.0245	0.0525	1.1	0.992	5.72e-07	NA	0.0574	0.33	0.592	0.0203	0.345	1.13	0.991	6.54e-07	NA
HCC70	MK2206	1	72	sigmoid	sigmoid	HCC70 MK-2206 0 1 72	8	1.444	0.314	-0.0266	0.337	0.618	-0.336	0.758	0.991	6.35e-07	NA	0.925	0.353	0.775	0.521	0.172	0.737	0.99	1.08e-06	NA
BT-549	GDC-0980	3	72	sigmoid	sigmoid	BT549 apitolisib 0 3 72	8	1.802	0.162	0.0283	0.377	0.158	0.0179	1.2	0.994	2.53e-07	NA	0.268	0.302	0.709	0.128	0.294	1.2	0.992	4.85e-07	NA
BT-549	Torin1	2	72	sigmoid	sigmoid	BT549 Torin1 0 2 72	8	1.881	0.0165	0.0298	0.618	0.0147	0.0572	1.03	0.993	4.2e-07	NA	0.0262	0.287	0.52	0.0111	0.306	1.1	0.99	9.68e-07	NA
HCC1806	Dactolisib	3	72	sigmoid	sigmoid	HCC1806 dactolisib 0 3 72	8	3.196	0.193	0.0324	0.393	0.437	-0.302	0.579	0.986	2.91e-06	NA	0.0977	0.121	0.559	0.093	0.0151	0.619	0.986	2.47e-06	NA
HCC38	AZD8055	3	72	sigmoid	sigmoid	HCC38 AZD8055 0 3 72	8	1.417	0.0464	0.0327	0.53	0.0463	0.000983	1.04	0.997	4.27e-08	NA	0.157	0.392	0.658	0.041	0.372	1.02	0.996	5.78e-08	NA
BT-20	Torin1	3	72	sigmoid	sigmoid	BT20 Torin1 0 3 72	8	2.569	0.0237	0.0343	0.572	0.0199	0.0736	0.899	0.993	2.77e-07	NA	0.0208	0.184	0.46	0.0119	0.204	0.944	0.997	2.51e-08	NA
HCC38	Torin1	2	72	sigmoid	sigmoid	HCC38 Torin1 0 2 72	8	2.136	0.0241	0.0393	0.573	0.0203	0.0651	0.82	0.995	1.24e-07	NA	0.0309	0.247	0.512	0.013	0.267	0.88	0.996	4.87e-08	NA
HCC70	ZSTK474	2	72	sigmoid	sigmoid	HCC70 ZSTK474 0 2 72	8	1.737	0.248	-0.0397	0.324	0.27	-0.0591	1.33	0.992	5.33e-07	NA	0.379	0.28	0.76	0.214	0.28	1.43	0.989	1.22e-06	NA
HCC38	Dactolisib	1	72	sigmoid	sigmoid	HCC38 dactolisib 0 1 72	8	1.821	0.0109	-0.0403	0.672	0.0104	0.0212	0.892	0.985	3.44e-06	NA	0.0194	0.263	0.492	0.00757	0.301	0.975	0.988	1.65e-06	NA
BT-20	Alpelisib	1	72	sigmoid	sigmoid	BT20 alpelisib 0 1 72	8	2.077	1.14	0.046	0.196	3.52	-1.0	0.977	0.966	4.1e-05	NA	1.32	0.26	0.825	1.32	0.0	1.13	0.942	0.000194	NA
BT-20	Pictilisib	2	72	sigmoid	sigmoid	BT20 pictilisib 0 2 72	8	1.746	0.308	-0.0521	0.379	2.35	-1.0	0.54	0.791	0.00908	NA	0.634	0.272	0.712	0.634	0.0	0.6	0.716	0.0229	NA
HCC1806	Dactolisib	2	72	sigmoid	sigmoid	HCC1806 dactolisib 0 2 72	8	2.828	0.145	-0.0528	0.433	0.401	-0.401	0.578	0.986	2.83e-06	NA	0.0977	0.121	0.559	0.0929	0.0151	0.619	0.986	2.47e-06	NA
HCC38	Dactolisib	2	72	sigmoid	sigmoid	HCC38 dactolisib 0 2 72	8	2.120	0.0118	-0.0557	0.668	0.0118	-0.00134	0.785	0.98	7.61e-06	NA	0.0145	0.204	0.447	0.00701	0.245	0.927	0.988	1.88e-06	NA
Hs 578T	GDC-0980	2		sigmoid	sigmoid	Hs578T apitolisib 2	8	2.520	0.176	-0.0558	0.391	0.275	-0.201	0.758	0.997	3.91e-08	NA	0.159	0.151	0.627	0.121	0.1	0.818	0.998	1.45e-08	NA
Hs 578T	Dactolisib	3		sigmoid	sigmoid	Hs578T dactolisib 3	8	2.837	0.0118	0.0569	0.624	0.00848	0.115	0.799	0.96	6.53e-05	NA	0.00728	0.164	0.377	0.0043	0.212	1.05	0.968	3.34e-05	NA
Hs 578T	GDC-0980	1		sigmoid	sigmoid	Hs578T apitolisib 1	8	1.984	0.119	-0.0587	0.419	0.141	-0.0865	0.957	0.997	3.35e-08	NA	0.161	0.224	0.662	0.0914	0.223	1.04	0.997	2.87e-08	NA
Hs 578T	WYE-125132	1		sigmoid	sigmoid	Hs578T WYE-132 1	8	2.015	0.0322	0.0601	0.551	0.0286	0.0544	0.962	0.998	4.17e-09	NA	0.0469	0.278	0.55	0.0207	0.275	0.978	0.999	2.33e-09	NA
BT-549	Torin1	1	72	sigmoid	sigmoid	BT549 Torin1 0 1 72	8	1.794	0.017	0.0603	0.621	0.0151	0.056	0.976	0.998	7.25e-09	NA	0.0333	0.32	0.532	0.0118	0.316	0.966	0.998	9.27e-09	NA
Hs 578T	Dactolisib	1		sigmoid	sigmoid	Hs578T dactolisib 1	8	2.047	0.00952	-0.0606	0.691	0.00928	0.0117	0.91	0.977	1.27e-05	NA	0.0124	0.213	0.443	0.00621	0.259	1.06	0.985	3.61e-06	NA
Hs 578T	Dactolisib	2		sigmoid	sigmoid	Hs578T dactolisib 2	8	2.509	0.0128	-0.0617	0.655	0.0126	0.00741	0.79	0.974	1.78e-05	NA	0.0105	0.15	0.405	0.00638	0.203	1.04	0.985	3.67e-06	NA
Hs 578T	Trametinib	3		sigmoid	sigmoid	Hs578T trametinib 3	8	2.830	0.0128	0.0657	0.644	0.0112	0.0447	0.702	0.998	4.02e-09	NA	0.00864	0.168	0.366	0.00512	0.157	0.722	0.998	5.57e-09	NA
HCC70	Dactolisib	1	72	sigmoid	sigmoid	HCC70 dactolisib 0 1 72	8	1.400	0.0808	-0.0667	0.501	3.34	-1.0	0.295	0.963	5.02e-05	NA	0.753	0.344	0.673	0.753	0.0	0.308	0.962	5.37e-05	NA
Hs 578T	AZD8055	1		sigmoid	sigmoid	Hs578T AZD8055 1	8	2.009	0.0391	0.073	0.531	0.0347	0.0546	0.975	0.995	1.39e-07	NA	0.0591	0.286	0.565	0.0259	0.27	0.941	0.994	1.73e-07	NA
Hs 578T	Trametinib	2		sigmoid	sigmoid	Hs578T trametinib 2	8	2.483	0.00633	0.074	0.701	0.00558	0.0362	0.593	0.998	1.32e-08	NA	0.0058	0.214	0.361	0.00257	0.193	0.602	0.998	3.66e-09	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)