Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

 Full screen view
Filter results: >>>>
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 Dactolisib 2 72
sigmoid
sigmoid
HCC1806 dactolisib 0 2 72
 8 2.828
0.145
-0.0528
0.433
0.401
-0.401
0.578
0.986
2.83e-06
NA
0.0977
0.121
0.559
0.0929
0.0151
0.619
0.986
2.47e-06
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
HCC38 Buparlisib 2 72
sigmoid
sigmoid
HCC38 buparlisib 0 2 72
 8 2.142
0.876
-0.185
0.172
1.24
-0.413
1.74
0.996
5.03e-08
NA
0.959
0.146
0.861
0.893
0.0606
1.8
0.992
4.3e-07
NA
Hs 578T KIN001-244 1
sigmoid
sigmoid
Hs578T KIN001-244 1
 8 2.041
24.7
0.739
0.0391
4.05
0.414
0.972
0.968
3.4e-05
NA
Inf
0.752
0.962
3.15
0.51
0.99
0.964
4.65e-05
NA
HCC1806 Buparlisib 1 72
sigmoid
sigmoid
HCC1806 buparlisib 0 1 72
 8 2.742
0.748
-0.369
0.226
0.931
-0.415
2.75
1.0
2.95e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC38 Everolimus 2 72
sigmoid
flat
HCC38 everolimus 0 2 72
 8 2.170
8323.0
0.58
0.376
0.000127
0.417
0.1
0.688
0.0303
NA
Inf
0.6
0.637
0.0
0.6
0.01
0.509
0.119
0.637
BT-20 Sirolimus 2 72
flat
flat
BT20 rapamycin 0 2 72
 8 1.952
Inf
0.421
0.579
0.0
0.421
0.01
NA
NA
0.421
Inf
0.513
0.513
0.0
0.513
0.01
NA
NA
0.513
HCC70 CAL-101 1 72
sigmoid
sigmoid
HCC70 idelalisib 0 1 72
 8 1.384
2.78
0.485
0.0894
0.883
0.424
1.65
0.972
2.11e-05
NA
Inf
0.662
0.941
0.846
0.626
1.66
0.97
2.79e-05
NA
HCC1806 Dactolisib 1 72
sigmoid
sigmoid
HCC1806 dactolisib 0 1 72
 8 2.743
0.135
-0.0744
0.444
0.391
-0.425
0.577
0.986
2.81e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
BT-20 Everolimus 2 72
flat
flat
BT20 everolimus 0 2 72
 8 1.785
Inf
0.426
0.574
0.0
0.426
0.01
NA
NA
0.426
Inf
0.547
0.547
0.0
0.547
0.01
NA
NA
0.547
Hs 578T Everolimus 1
sigmoid
sigmoid
Hs578T everolimus 1
 8 2.030
1707115.0
0.626
0.318
0.00576
0.429
0.1
0.895
0.00116
NA
2.51e+21
0.657
0.704
0.00121
0.502
0.1
0.893
0.00124
NA
Hs 578T Sirolimus 1
sigmoid
sigmoid
Hs578T rapamycin 1
 8 2.013
110643.0
0.587
0.358
0.000237
0.432
0.1
0.879
0.00178
NA
9.61e+11
0.628
0.672
0.000175
0.487
0.1
0.851
0.00332
NA
HCC38 BX-912 3 72
sigmoid
sigmoid
HCC38 BX-912 0 3 72
 8 1.454
0.422
-0.428
0.365
0.478
-0.433
5.0
0.993
4.02e-07
NA
0.496
0.162
0.778
0.46
0.159
5.0
0.989
1.24e-06
NA
Hs 578T BX-912 1
sigmoid
sigmoid
Hs578T BX-912 1
 8 2.001
0.771
-0.202
0.191
1.16
-0.444
1.57
0.997
2.97e-08
NA
0.901
0.159
0.851
0.822
0.0702
1.64
0.994
1.9e-07
NA
HCC1806 WYE-125132 1 72
sigmoid
sigmoid
HCC1806 WYE-132 0 1 72
 8 2.790
0.603
0.466
0.292
0.0448
0.45
0.883
0.997
3.72e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
BT-549 Sirolimus 3 72
flat
flat
BT549 rapamycin 0 3 72
 8 1.703
Inf
0.455
0.482
0.0
0.455
0.01
0.376
0.243
0.518
Inf
0.582
0.626
0.0
0.582
0.01
0.436
0.179
0.625
BT-20 Trametinib 1 72
sigmoid
sigmoid
BT20 trametinib 0 1 72
 8 2.016
14.3
0.54
0.225
0.135
0.458
0.534
0.989
1.3e-06
NA
Inf
0.59
0.791
0.0955
0.534
0.545
0.989
1.43e-06
NA
HCC1806 WYE-125132 2 72
sigmoid
sigmoid
HCC1806 WYE-132 0 2 72
 8 2.874
0.872
0.479
0.284
0.045
0.464
0.883
0.997
3.66e-08
NA
0.226
0.42
0.663
0.0335
0.402
0.855
0.996
8.79e-08
NA
HCC70 Trametinib 2 72
sigmoid
sigmoid
HCC70 trametinib 0 2 72
 8 1.721
0.506
0.504
0.395
0.00469
0.467
0.581
0.944
0.000179
NA
Inf
0.612
0.687
0.00389
0.585
0.57
0.948
0.000138
NA
HCC70 WYE-125132 2 72
sigmoid
sigmoid
HCC70 WYE-132 0 2 72
 8 1.675
0.213
0.471
0.332
0.0211
0.467
1.18
0.996
6.89e-08
NA
Inf
0.598
0.744
0.0194
0.595
1.17
0.996
7.52e-08
NA
BT-20 Everolimus 3 72
flat
flat
BT20 everolimus 0 3 72
 8 2.422
Inf
0.475
0.456
0.0
0.475
0.01
0.602
0.0632
0.543
Inf
0.478
0.534
0.0
0.478
0.01
0.561
0.0844
0.534
Hs 578T Everolimus 2
sigmoid
sigmoid
Hs578T everolimus 2
 8 2.550
3210000000.0
0.626
0.335
0.000205
0.476
0.1
0.791
0.00913
NA
18938.0
0.59
0.627
0.000153
0.422
0.1
0.745
0.0166
NA
Hs 578T BX-912 2
sigmoid
sigmoid
Hs578T BX-912 2
 8 2.540
1.07
-0.019
0.174
1.79
-0.489
1.33
0.998
6.37e-09
NA
1.01
0.164
0.828
1.01
0.0
1.4
0.996
7.64e-08
NA
HCC1806 MK2206 3 72
sigmoid
sigmoid
HCC1806 MK-2206 0 3 72
 8 3.199
74.1
0.843
0.0434
320.0
-0.491
0.468
0.981
6.96e-06
NA
Inf
0.769
0.934
4.46
0.507
0.566
0.976
1.46e-05
NA