Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
BT-20	AS605240	1	72	sigmoid	sigmoid	BT20 AS-605240 0 1 72	8	2.142	Inf	0.817	0.0993	3.91	0.634	0.244	0.861	0.00271	NA	Inf	0.814	0.897	3.87	0.629	0.237	0.854	0.00311	NA
HCC38	Omipalisib	1	72	sigmoid	sigmoid	HCC38 omipalisib 0 1 72	8	1.760	0.0231	-0.316	0.672	0.152	-0.638	0.438	0.97	2.61e-05	NA	0.0585	0.151	0.512	0.0499	0.0356	0.465	0.956	8.65e-05	NA
HCC1806	ZSTK474	3	72	sigmoid	sigmoid	HCC1806 ZSTK474 0 3 72	8	3.162	Inf	0.654	0.0322	1.18	0.65	4.68	0.99	1.03e-06	NA	Inf	0.548	0.958	1.12	0.545	4.88	0.985	3.14e-06	NA
BT-20	AS605240	3	72	sigmoid	sigmoid	BT20 AS-605240 0 3 72	8	2.607	Inf	0.845	0.0823	4.13	0.662	0.292	0.729	0.0199	NA	Inf	0.81	0.897	3.97	0.589	0.284	0.712	0.0239	NA
BT-549	Alpelisib	2	72	sigmoid	sigmoid	BT549 alpelisib 0 2 72	8	1.927	Inf	0.832	0.0409	4.24	0.663	0.548	0.706	0.0254	NA	Inf	0.844	0.962	4.26	0.686	0.542	0.696	0.0282	NA
BT-549	CAL-101	3	72	sigmoid	sigmoid	BT549 idelalisib 0 3 72	8	1.770	43.0	0.79	0.0687	320.0	-0.664	0.421	0.862	0.00261	NA	118.0	0.822	0.941	118.0	0.0	0.425	0.854	0.00309	NA
Hs 578T	Everolimus	3		flat	flat	Hs578T everolimus 3	8	2.848	Inf	0.664	0.299	0.0	0.664	0.01	0.475	0.144	0.702	Inf	0.592	0.631	0.0	0.592	0.01	0.486	0.136	0.632
Hs 578T	MK2206	1		sigmoid	sigmoid	Hs578T MK-2206 1	8	2.039	Inf	0.608	0.165	0.087	0.665	2.09	0.9	0.00101	NA	Inf	0.641	0.845	0.0803	0.689	1.9	0.908	0.000775	NA
HCC1806	MK2206	2	72	sigmoid	sigmoid	HCC1806 MK-2206 0 2 72	8	2.831	51.9	0.823	0.0489	320.0	-0.668	0.467	0.981	7.01e-06	NA	Inf	0.769	0.934	4.46	0.507	0.566	0.976	1.45e-05	NA
Hs 578T	Alpelisib	2		flat	flat	Hs578T alpelisib 2	8	2.513	Inf	0.668	0.131	0.0	0.668	0.01	0.599	0.0647	0.856	Inf	0.634	0.847	0.0	0.634	0.01	0.541	0.0969	0.833
BT-549	Pictilisib	3	72	sigmoid	sigmoid	BT549 pictilisib 0 3 72	8	1.767	1.42	0.276	0.169	4.62	-0.67	0.722	0.998	9.61e-09	NA	2.47	0.452	0.863	2.47	0.0	0.742	0.997	2.13e-08	NA
HCC70	Everolimus	2	72	flat	flat	HCC70 everolimus 0 2 72	8	1.730	Inf	0.674	0.227	0.0	0.674	0.01	0.271	0.388	0.766	Inf	0.735	0.812	0.0	0.735	0.01	0.264	0.399	0.807
HCC70	TGX221	3	72	sigmoid	sigmoid	HCC70 TGX-221 0 3 72	8	2.459	Inf	0.7	0.0886	0.338	0.675	1.11	0.971	2.48e-05	NA	Inf	0.671	0.9	0.295	0.648	1.13	0.966	3.94e-05	NA
Hs 578T	Sirolimus	3		flat	flat	Hs578T rapamycin 3	8	2.836	Inf	0.675	0.309	0.0	0.675	0.01	-1.79	1.0	0.691	Inf	0.604	0.621	0.0	0.604	0.01	-3.02	1.0	0.621
BT-549	KIN001-244	3	72	sigmoid	sigmoid	BT549 KIN001-244 0 3 72	8	1.740	Inf	0.861	0.0287	4.69	0.681	0.74	0.922	0.00047	NA	Inf	0.882	0.975	4.7	0.729	0.732	0.919	0.000531	NA
BT-20	BX-912	2	72	flat	flat	BT20 BX-912 0 2 72	8	1.873	Inf	0.683	0.213	0.0	0.683	0.01	0.118	0.686	0.777	Inf	0.724	0.81	0.0	0.724	0.01	0.111	0.702	0.802
HCC70	Sirolimus	2	72	flat	flat	HCC70 rapamycin 0 2 72	8	1.762	Inf	0.685	0.257	0.0	0.685	0.01	0.531	0.103	0.741	Inf	0.739	0.785	0.0	0.739	0.01	0.524	0.108	0.783
HCC70	CAL-101	3	72	sigmoid	sigmoid	HCC70 idelalisib 0 3 72	8	2.510	Inf	0.724	0.0241	1.39	0.69	2.52	0.964	4.57e-05	NA	Inf	0.689	0.973	1.33	0.655	2.52	0.956	8.64e-05	NA
HCC38	AS605240	1	72	sigmoid	sigmoid	HCC38 AS-605240 0 1 72	8	1.744	Inf	0.734	0.0803	0.448	0.691	0.881	0.969	2.92e-05	NA	Inf	0.78	0.932	0.405	0.748	0.895	0.967	3.48e-05	NA
BT-549	KIN001-244	1	72	sigmoid	sigmoid	BT549 KIN001-244 0 1 72	8	1.802	Inf	0.872	0.0273	4.85	0.695	0.794	0.852	0.00324	NA	Inf	0.888	0.976	4.84	0.733	0.786	0.846	0.00362	NA
HCC70	Omipalisib	2	72	sigmoid	sigmoid	HCC70 omipalisib 0 2 72	8	1.682	0.00746	-0.705	1.01	0.0241	-0.703	0.749	0.991	6.69e-07	NA	0.0135	0.0399	0.359	0.0121	0.0458	0.852	0.989	1.45e-06	NA
HCC38	Torin2	3	72	sigmoid	sigmoid	HCC38 Torin2 0 3 72	8	1.385	0.013	-0.624	0.855	0.0547	-0.706	0.615	0.996	8.13e-08	NA	0.0407	0.0986	0.484	0.0311	0.0829	0.669	0.997	3.31e-08	NA
HCC1806	Sirolimus	1	72	sigmoid	sigmoid	HCC1806 rapamycin 0 1 72	8	2.796	1.35	0.775	0.187	0.00019	0.706	0.1	0.661	0.039	NA	1.05	0.717	0.76	1e-05	0.657	0.1	0.68	0.0328	NA
HCC1806	Omipalisib	3	72	sigmoid	sigmoid	HCC1806 omipalisib 0 3 72	8	3.217	0.147	-0.221	0.437	0.71	-0.707	0.559	0.981	7.41e-06	NA	0.0642	0.0481	0.54	0.0538	0.0749	0.919	0.979	9.93e-06	NA
BT-549	MK2206	3	72	sigmoid	sigmoid	BT549 MK-2206 0 3 72	8	1.685	Inf	0.714	0.131	0.123	0.711	3.44	0.953	0.000102	NA	Inf	0.771	0.895	0.123	0.768	3.25	0.949	0.000136	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)