Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

 Full screen view
Filter results: >>>>
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 PI103 2 72
sigmoid
sigmoid
BT549 PI-103 0 2 72
 8 1.893
0.218
0.0201
0.344
0.229
-0.0262
1.08
0.997
2.55e-08
NA
0.326
0.28
0.725
0.169
0.261
1.13
0.996
6.2e-08
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA
BT-20 Torin2 3 72
sigmoid
sigmoid
BT20 Torin2 0 3 72
 8 2.458
0.019
-0.64
0.751
0.234
-1.0
0.438
0.959
6.92e-05
NA
0.0147
0.0148
0.379
0.0123
0.0598
0.727
0.977
1.28e-05
NA
HCC70 AZD-6482 2 72
sigmoid
sigmoid
HCC70 AZD6482 0 2 72
 8 1.772
0.267
0.256
0.366
0.237
0.0255
0.43
0.987
2.27e-06
NA
1.16
0.438
0.706
0.133
0.306
0.437
0.986
3.03e-06
NA
Hs 578T Omipalisib 2
sigmoid
sigmoid
Hs578T omipalisib 2
 8 2.507
0.0155
-0.52
0.766
0.239
-1.0
0.402
0.993
3.45e-07
NA
0.0114
0.028
0.355
0.0114
0.0
0.468
0.981
6.9e-06
NA
HCC70 TGX221 1 72
sigmoid
sigmoid
HCC70 TGX-221 0 1 72
 8 1.381
0.539
0.344
0.244
0.245
0.278
1.03
0.986
2.58e-06
NA
Inf
0.578
0.84
0.229
0.536
1.02
0.986
2.87e-06
NA
HCC70 AS605240 1 72
sigmoid
sigmoid
HCC70 AS-605240 0 1 72
 8 1.387
10.4
0.487
0.159
0.247
0.497
1.34
0.963
5.14e-05
NA
Inf
0.663
0.894
0.23
0.672
1.39
0.961
6.01e-05
NA
HCC38 GDC-0980 2 72
sigmoid
sigmoid
HCC38 apitolisib 0 2 72
 8 2.159
0.33
0.153
0.279
0.253
0.117
1.0
0.992
4.91e-07
NA
0.385
0.304
0.749
0.165
0.308
1.13
0.994
2.09e-07
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
HCC70 ZSTK474 2 72
sigmoid
sigmoid
HCC70 ZSTK474 0 2 72
 8 1.737
0.248
-0.0397
0.324
0.27
-0.0591
1.33
0.992
5.33e-07
NA
0.379
0.28
0.76
0.214
0.28
1.43
0.989
1.22e-06
NA
Hs 578T GDC-0980 2
sigmoid
sigmoid
Hs578T apitolisib 2
 8 2.520
0.176
-0.0558
0.391
0.275
-0.201
0.758
0.997
3.91e-08
NA
0.159
0.151
0.627
0.121
0.1
0.818
0.998
1.45e-08
NA
HCC38 TGX221 1 72
sigmoid
sigmoid
HCC38 TGX-221 0 1 72
 8 1.724
Inf
0.938
0.0116
0.289
0.941
5.0
0.676
0.0342
NA
Inf
0.947
0.99
0.289
0.949
5.0
0.672
0.0354
NA
BT-20 PI103 2 72
sigmoid
sigmoid
BT20 PI-103 0 2 72
 8 1.725
0.235
-0.21
0.388
0.289
-0.212
1.7
0.975
1.64e-05
NA
0.319
0.202
0.721
0.239
0.205
1.81
0.961
5.88e-05
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
BT-549 TGX221 1 72
sigmoid
sigmoid
BT549 TGX-221 0 1 72
 8 1.826
Inf
0.821
0.0771
0.297
0.777
0.632
0.868
0.00232
NA
Inf
0.842
0.931
0.313
0.799
0.603
0.863
0.00255
NA
HCC70 MK2206 2 72
sigmoid
sigmoid
HCC70 MK-2206 0 2 72
 8 1.690
0.446
0.244
0.2
0.301
0.226
1.53
0.973
1.92e-05
NA
1.03
0.448
0.851
0.266
0.44
1.56
0.965
4.11e-05
NA
Hs 578T PI103 2
sigmoid
sigmoid
Hs578T PI-103 2
 8 2.503
0.223
-0.0213
0.356
0.303
-0.15
0.858
0.999
7.33e-10
NA
0.206
0.167
0.661
0.152
0.121
0.921
0.999
1.9e-09
NA
HCC38 AZD-6482 3 72
sigmoid
sigmoid
HCC38 AZD6482 0 3 72
 8 1.420
Inf
0.821
0.0615
0.324
0.826
5.0
0.849
0.00342
NA
Inf
0.875
0.957
0.323
0.879
5.0
0.846
0.00367
NA
Hs 578T AS605240 1
sigmoid
sigmoid
Hs578T AS-605240 1
 8 2.015
0.758
0.341
0.212
0.333
0.265
0.921
0.991
7.83e-07
NA
1.42
0.447
0.811
0.246
0.408
0.964
0.989
1.51e-06
NA
HCC70 TGX221 3 72
sigmoid
sigmoid
HCC70 TGX-221 0 3 72
 8 2.459
Inf
0.7
0.0886
0.338
0.675
1.11
0.971
2.48e-05
NA
Inf
0.671
0.9
0.295
0.648
1.13
0.966
3.94e-05
NA
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
BT-20 ZSTK474 2 72
sigmoid
sigmoid
BT20 ZSTK474 0 2 72
 8 1.787
0.286
-0.19
0.347
0.373
-0.234
1.46
0.992
4.53e-07
NA
0.391
0.199
0.743
0.29
0.184
1.55
0.988
1.84e-06
NA
BT-20 PI103 3 72
sigmoid
sigmoid
BT20 PI-103 0 3 72
 8 2.496
0.373
0.0139
0.282
0.387
-0.0286
1.52
0.994
1.99e-07
NA
0.359
0.183
0.735
0.279
0.162
1.56
0.988
1.71e-06
NA