Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 Torin2 1 72
sigmoid
sigmoid
HCC70 Torin2 0 1 72
 8 1.364
0.0288
-0.732
0.772
0.183
-1.0
0.594
0.991
6.58e-07
NA
0.088
0.0644
0.539
0.088
0.0
0.622
0.988
1.95e-06
NA
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
 8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
HCC70 Torin2 2 72
sigmoid
sigmoid
HCC70 Torin2 0 2 72
 8 1.826
0.0342
-0.522
0.671
0.401
-1.0
0.446
0.979
9.23e-06
NA
0.0639
0.0733
0.507
0.0639
0.0
0.462
0.969
2.98e-05
NA
BT-20 Buparlisib 1 72
sigmoid
sigmoid
BT20 buparlisib 0 1 72
 8 2.131
0.598
-0.394
0.285
1.19
-0.763
1.35
0.992
4.68e-07
NA
0.663
0.0784
0.766
0.663
0.0
1.49
0.981
7.06e-06
NA
HCC1806 Torin2 2 72
sigmoid
sigmoid
HCC1806 Torin2 0 2 72
 8 2.843
0.0589
-0.181
0.57
0.0771
-0.211
1.3
0.996
6.72e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.08e-07
NA
HCC1806 Torin2 3 72
sigmoid
sigmoid
HCC1806 Torin2 0 3 72
 8 3.212
0.0678
-0.0927
0.522
0.0798
-0.12
1.32
0.996
6.56e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
HCC1806 Torin2 1 72
sigmoid
sigmoid
HCC1806 Torin2 0 1 72
 8 2.759
0.0569
-0.203
0.582
0.0763
-0.234
1.3
0.996
6.76e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
Hs 578T Torin2 1
sigmoid
sigmoid
Hs578T Torin2 1
 8 2.031
0.015
-0.405
0.761
0.0631
-0.56
0.522
0.992
5.31e-07
NA
0.021
0.0851
0.419
0.0163
0.0756
0.64
0.993
3.63e-07
NA
HCC38 Torin2 3 72
sigmoid
sigmoid
HCC38 Torin2 0 3 72
 8 1.385
0.013
-0.624
0.855
0.0547
-0.706
0.615
0.996
8.13e-08
NA
0.0407
0.0986
0.484
0.0311
0.0829
0.669
0.997
3.31e-08
NA
Hs 578T Omipalisib 3
sigmoid
sigmoid
Hs578T omipalisib 3
 8 2.869
0.0255
-0.107
0.615
0.0533
-0.22
0.494
0.99
8.79e-07
NA
0.0145
0.0989
0.392
0.0102
0.0968
0.62
0.993
3.4e-07
NA
BT-20 Buparlisib 2 72
sigmoid
sigmoid
BT20 buparlisib 0 2 72
 8 1.743
0.334
-0.45
0.391
0.844
-0.82
1.05
0.972
2.21e-05
NA
0.487
0.105
0.718
0.487
0.0
1.12
0.948
0.000142
NA
HCC1806 Dactolisib 3 72
sigmoid
sigmoid
HCC1806 dactolisib 0 3 72
 8 3.196
0.193
0.0324
0.393
0.437
-0.302
0.579
0.986
2.91e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
HCC1806 Dactolisib 1 72
sigmoid
sigmoid
HCC1806 dactolisib 0 1 72
 8 2.743
0.135
-0.0744
0.444
0.391
-0.425
0.577
0.986
2.81e-06
NA
0.0977
0.121
0.559
0.093
0.0151
0.619
0.986
2.47e-06
NA
HCC1806 Dactolisib 2 72
sigmoid
sigmoid
HCC1806 dactolisib 0 2 72
 8 2.828
0.145
-0.0528
0.433
0.401
-0.401
0.578
0.986
2.83e-06
NA
0.0977
0.121
0.559
0.0929
0.0151
0.619
0.986
2.47e-06
NA
HCC70 Buparlisib 3 72
sigmoid
sigmoid
HCC70 buparlisib 0 3 72
 8 2.439
0.968
-0.156
0.167
1.7
-0.624
1.43
0.995
1.16e-07
NA
0.944
0.122
0.852
0.944
0.0
1.57
0.988
1.57e-06
NA
HCC38 BX-912 2 72
sigmoid
sigmoid
HCC38 BX-912 0 2 72
 8 2.186
0.583
-0.229
0.251
0.648
-0.233
3.62
0.999
9.58e-10
NA
0.602
0.124
0.807
0.559
0.123
3.78
0.998
1.03e-08
NA
BT-20 GDC-0980 1 72
sigmoid
sigmoid
BT20 apitolisib 0 1 72
 8 2.001
0.0935
-0.289
0.498
0.128
-0.251
1.29
0.994
2.71e-07
NA
0.113
0.126
0.62
0.0885
0.151
1.48
0.996
7.34e-08
NA
BT-549 Omipalisib 2 72
sigmoid
sigmoid
BT549 omipalisib 0 2 72
 8 1.990
0.0104
-0.291
0.751
0.026
-0.32
0.542
0.966
4.09e-05
NA
0.0175
0.127
0.422
0.011
0.118
0.58
0.953
0.000102
NA
BT-20 GDC-0980 3 72
sigmoid
sigmoid
BT20 apitolisib 0 3 72
 8 2.502
0.0976
-0.115
0.437
0.107
-0.0716
1.53
0.994
2.41e-07
NA
0.0894
0.13
0.62
0.0732
0.163
1.96
0.996
6.83e-08
NA
BT-20 GDC-0980 2 72
sigmoid
sigmoid
BT20 apitolisib 0 2 72
 8 1.659
0.0456
-0.414
0.639
0.0629
-0.33
1.58
0.993
4.18e-07
NA
0.0641
0.131
0.575
0.0506
0.168
1.74
0.995
1.2e-07
NA
BT-549 Buparlisib 3 72
sigmoid
sigmoid
BT549 buparlisib 0 3 72
 8 1.795
0.602
-0.351
0.295
1.64
-1.0
1.09
0.983
4.52e-06
NA
0.804
0.132
0.777
0.804
0.0
1.26
0.968
3.41e-05
NA
BT-549 Buparlisib 2 72
sigmoid
sigmoid
BT549 buparlisib 0 2 72
 8 1.913
0.681
-0.306
0.217
1.08
-0.538
1.59
0.998
1.31e-08
NA
0.821
0.132
0.838
0.769
0.0514
1.66
0.996
8.95e-08
NA
HCC38 Omipalisib 3 72
sigmoid
sigmoid
HCC38 omipalisib 0 3 72
 8 1.446
0.0145
-0.503
0.802
0.0539
-0.597
0.6
0.993
3.08e-07
NA
0.0449
0.134
0.499
0.0308
0.107
0.644
0.993
2.98e-07
NA
BT-549 Buparlisib 1 72
sigmoid
sigmoid
BT549 buparlisib 0 1 72
 8 1.837
0.729
-0.325
0.253
1.83
-1.0
1.19
0.994
2.4e-07
NA
0.926
0.136
0.807
0.926
0.0
1.37
0.987
2.46e-06
NA
HCC38 Buparlisib 2 72
sigmoid
sigmoid
HCC38 buparlisib 0 2 72
 8 2.142
0.876
-0.185
0.172
1.24
-0.413
1.74
0.996
5.03e-08
NA
0.959
0.146
0.861
0.893
0.0606
1.8
0.992
4.3e-07
NA