Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-20 | Sirolimus | 2 | 72 | flat | flat | BT20 rapamycin 0 2 72 | 8 | 1.952 | Inf | 0.421 | 0.579 | 0.0 | 0.421 | 0.01 | NA | NA | 0.421 | Inf | 0.513 | 0.513 | 0.0 | 0.513 | 0.01 | NA | NA | 0.513 |
Hs 578T | AS605240 | 3 | sigmoid | sigmoid | Hs578T AS-605240 3 | 8 | 2.856 | 63.8 | 0.588 | 0.0965 | 0.826 | 0.494 | 1.03 | 0.983 | 4.89e-06 | NA | 5.75 | 0.518 | 0.879 | 0.552 | 0.465 | 1.14 | 0.981 | 6.87e-06 | NA | |
HCC70 | AZD8055 | 1 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 1 72 | 8 | 1.339 | 0.0485 | 0.242 | 0.442 | 0.0243 | 0.26 | 1.06 | 0.976 | 1.32e-05 | NA | Inf | 0.529 | 0.721 | 0.0222 | 0.54 | 1.08 | 0.974 | 1.81e-05 | NA |
BT-549 | Pictilisib | 1 | 72 | sigmoid | sigmoid | BT549 pictilisib 0 1 72 | 8 | 1.772 | 2.08 | 0.415 | 0.117 | 1.42 | 0.154 | 0.959 | 0.987 | 2.26e-06 | NA | 5.12 | 0.541 | 0.904 | 1.06 | 0.396 | 0.995 | 0.985 | 3.49e-06 | NA |
HCC70 | Trametinib | 3 | 72 | sigmoid | sigmoid | HCC70 trametinib 0 3 72 | 8 | 2.463 | Inf | 0.56 | 0.361 | 0.00419 | 0.548 | 0.954 | 0.95 | 0.000123 | NA | Inf | 0.542 | 0.618 | 0.00342 | 0.533 | 0.965 | 0.958 | 7.33e-05 | NA |
HCC70 | AZD8055 | 2 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 2 72 | 8 | 1.724 | 0.17 | 0.404 | 0.346 | 0.0331 | 0.385 | 0.897 | 0.996 | 7.36e-08 | NA | Inf | 0.543 | 0.728 | 0.0284 | 0.531 | 0.905 | 0.996 | 6.22e-08 | NA |
BT-20 | Everolimus | 2 | 72 | flat | flat | BT20 everolimus 0 2 72 | 8 | 1.785 | Inf | 0.426 | 0.574 | 0.0 | 0.426 | 0.01 | NA | NA | 0.426 | Inf | 0.547 | 0.547 | 0.0 | 0.547 | 0.01 | NA | NA | 0.547 |
HCC1806 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | HCC1806 ZSTK474 0 1 72 | 8 | 2.709 | Inf | 0.602 | 0.037 | 1.17 | 0.599 | 4.88 | 0.99 | 1.12e-06 | NA | Inf | 0.548 | 0.958 | 1.12 | 0.545 | 4.88 | 0.985 | 3.14e-06 | NA |
HCC1806 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | HCC1806 ZSTK474 0 3 72 | 8 | 3.162 | Inf | 0.654 | 0.0322 | 1.18 | 0.65 | 4.68 | 0.99 | 1.03e-06 | NA | Inf | 0.548 | 0.958 | 1.12 | 0.545 | 4.88 | 0.985 | 3.14e-06 | NA |
HCC1806 | ZSTK474 | 2 | 72 | sigmoid | sigmoid | HCC1806 ZSTK474 0 2 72 | 8 | 2.794 | Inf | 0.613 | 0.036 | 1.16 | 0.61 | 5.0 | 0.99 | 1.1e-06 | NA | Inf | 0.548 | 0.958 | 1.12 | 0.545 | 4.88 | 0.985 | 3.14e-06 | NA |
HCC70 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC70 AZD8055 0 3 72 | 8 | 2.442 | Inf | 0.571 | 0.287 | 0.0133 | 0.574 | 1.17 | 0.98 | 8.55e-06 | NA | Inf | 0.554 | 0.694 | 0.0116 | 0.556 | 1.17 | 0.974 | 1.69e-05 | NA |
HCC70 | AS605240 | 3 | 72 | sigmoid | sigmoid | HCC70 AS-605240 0 3 72 | 8 | 2.447 | Inf | 0.58 | 0.112 | 0.427 | 0.549 | 1.18 | 0.985 | 3.24e-06 | NA | Inf | 0.562 | 0.877 | 0.345 | 0.544 | 1.24 | 0.982 | 6.14e-06 | NA |
HCC70 | Trametinib | 1 | 72 | sigmoid | sigmoid | HCC70 trametinib 0 1 72 | 8 | 1.421 | 0.015 | 0.339 | 0.521 | 0.00411 | 0.34 | 0.879 | 0.966 | 4.1e-05 | NA | Inf | 0.566 | 0.653 | 0.00373 | 0.566 | 0.875 | 0.968 | 3.23e-05 | NA |
Hs 578T | AZD-6482 | 2 | sigmoid | sigmoid | Hs578T AZD6482 2 | 8 | 2.508 | 6.35 | 0.602 | 0.121 | 74.8 | -1.0 | 0.445 | 0.998 | 1.12e-08 | NA | 6.4 | 0.573 | 0.86 | 6.4 | 0.0 | 0.475 | 0.996 | 6.36e-08 | NA | |
HCC70 | TGX221 | 2 | 72 | sigmoid | sigmoid | HCC70 TGX-221 0 2 72 | 8 | 1.786 | 1.77 | 0.467 | 0.233 | 0.531 | 0.227 | 0.503 | 0.948 | 0.000139 | NA | 5.85 | 0.575 | 0.806 | 3.44 | 0.0897 | 0.372 | 0.937 | 0.000249 | NA |
HCC38 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | HCC38 ZSTK474 0 1 72 | 8 | 1.742 | 2.47 | 0.456 | 0.132 | 1.34 | 0.202 | 0.843 | 0.991 | 7.12e-07 | NA | 9.02 | 0.575 | 0.893 | 1.0 | 0.426 | 0.869 | 0.99 | 1.01e-06 | NA |
HCC70 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC70 WYE-132 0 3 72 | 8 | 2.417 | Inf | 0.592 | 0.246 | 0.0209 | 0.606 | 1.64 | 0.995 | 1.48e-07 | NA | Inf | 0.576 | 0.739 | 0.019 | 0.588 | 1.64 | 0.996 | 7.52e-08 | NA |
HCC70 | TGX221 | 1 | 72 | sigmoid | sigmoid | HCC70 TGX-221 0 1 72 | 8 | 1.381 | 0.539 | 0.344 | 0.244 | 0.245 | 0.278 | 1.03 | 0.986 | 2.58e-06 | NA | Inf | 0.578 | 0.84 | 0.229 | 0.536 | 1.02 | 0.986 | 2.87e-06 | NA |
HCC70 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | HCC70 WYE-132 0 1 72 | 8 | 1.382 | 0.0518 | 0.346 | 0.418 | 0.0175 | 0.348 | 1.1 | 0.985 | 3.58e-06 | NA | Inf | 0.579 | 0.727 | 0.0165 | 0.579 | 1.09 | 0.983 | 4.63e-06 | NA |
BT-549 | Sirolimus | 3 | 72 | flat | flat | BT549 rapamycin 0 3 72 | 8 | 1.703 | Inf | 0.455 | 0.482 | 0.0 | 0.455 | 0.01 | 0.376 | 0.243 | 0.518 | Inf | 0.582 | 0.626 | 0.0 | 0.582 | 0.01 | 0.436 | 0.179 | 0.625 |
Hs 578T | Sirolimus | 2 | flat | flat | Hs578T rapamycin 2 | 8 | 2.536 | Inf | 0.623 | 0.341 | 0.0 | 0.623 | 0.01 | 0.16 | 0.593 | 0.66 | Inf | 0.589 | 0.623 | 0.0 | 0.589 | 0.01 | -0.232 | 1.0 | 0.624 | |
Hs 578T | Everolimus | 2 | sigmoid | sigmoid | Hs578T everolimus 2 | 8 | 2.550 | 3210000000.0 | 0.626 | 0.335 | 0.000205 | 0.476 | 0.1 | 0.791 | 0.00913 | NA | 18938.0 | 0.59 | 0.627 | 0.000153 | 0.422 | 0.1 | 0.745 | 0.0166 | NA | |
BT-20 | Trametinib | 1 | 72 | sigmoid | sigmoid | BT20 trametinib 0 1 72 | 8 | 2.016 | 14.3 | 0.54 | 0.225 | 0.135 | 0.458 | 0.534 | 0.989 | 1.3e-06 | NA | Inf | 0.59 | 0.791 | 0.0955 | 0.534 | 0.545 | 0.989 | 1.43e-06 | NA |
Hs 578T | Everolimus | 3 | flat | flat | Hs578T everolimus 3 | 8 | 2.848 | Inf | 0.664 | 0.299 | 0.0 | 0.664 | 0.01 | 0.475 | 0.144 | 0.702 | Inf | 0.592 | 0.631 | 0.0 | 0.592 | 0.01 | 0.486 | 0.136 | 0.632 | |
HCC38 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | HCC38 ZSTK474 0 3 72 | 8 | 1.458 | 2.06 | 0.398 | 0.146 | 5.06 | -0.41 | 0.665 | 0.989 | 1.23e-06 | NA | 6.44 | 0.593 | 0.898 | 3.35 | 0.179 | 0.678 | 0.988 | 1.64e-06 | NA |