Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
HCC38 Torin1 2 72
sigmoid
sigmoid
HCC38 Torin1 0 2 72
 8 2.136
0.0241
0.0393
0.573
0.0203
0.0651
0.82
0.995
1.24e-07
NA
0.0309
0.247
0.512
0.013
0.267
0.88
0.996
4.87e-08
NA
Hs 578T AZD8055 1
sigmoid
sigmoid
Hs578T AZD8055 1
 8 2.009
0.0391
0.073
0.531
0.0347
0.0546
0.975
0.995
1.39e-07
NA
0.0591
0.286
0.565
0.0259
0.27
0.941
0.994
1.73e-07
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
Hs 578T WYE-125132 1
sigmoid
sigmoid
Hs578T WYE-132 1
 8 2.015
0.0322
0.0601
0.551
0.0286
0.0544
0.962
0.998
4.17e-09
NA
0.0469
0.278
0.55
0.0207
0.275
0.978
0.999
2.33e-09
NA
HCC38 Dactolisib 3 72
sigmoid
sigmoid
HCC38 dactolisib 0 3 72
 8 1.468
0.0082
-0.197
0.778
0.0127
-0.181
0.711
0.993
3.98e-07
NA
0.0268
0.262
0.497
0.00923
0.277
0.757
0.994
2.62e-07
NA
HCC70 Pictilisib 2 72
sigmoid
sigmoid
HCC70 pictilisib 0 2 72
 8 1.783
0.811
0.124
0.189
0.858
-0.0372
1.27
0.973
2.08e-05
NA
1.25
0.358
0.852
0.678
0.278
1.32
0.963
5.09e-05
NA
BT-549 PI103 3 72
sigmoid
sigmoid
BT549 PI-103 0 3 72
 8 1.758
0.16
0.00249
0.391
0.166
-0.0225
1.12
0.989
1.19e-06
NA
0.279
0.297
0.704
0.134
0.28
1.12
0.985
3.23e-06
NA
HCC70 ZSTK474 2 72
sigmoid
sigmoid
HCC70 ZSTK474 0 2 72
 8 1.737
0.248
-0.0397
0.324
0.27
-0.0591
1.33
0.992
5.33e-07
NA
0.379
0.28
0.76
0.214
0.28
1.43
0.989
1.22e-06
NA
Hs 578T Torin1 1
sigmoid
sigmoid
Hs578T Torin1 1
 8 1.956
0.0217
0.0183
0.598
0.0203
0.0286
0.911
0.994
1.81e-07
NA
0.0321
0.267
0.524
0.0141
0.28
0.995
0.996
8.78e-08
NA
HCC38 AZD8055 2 72
sigmoid
sigmoid
HCC38 AZD8055 0 2 72
 8 2.128
0.0616
0.16
0.467
0.045
0.124
0.912
0.993
3.13e-07
NA
0.0875
0.314
0.594
0.0332
0.284
0.869
0.991
6.5e-07
NA
HCC38 WYE-125132 2 72
sigmoid
sigmoid
HCC38 WYE-132 0 2 72
 8 2.143
0.0568
0.149
0.473
0.0413
0.124
0.896
0.998
9.66e-09
NA
0.078
0.305
0.587
0.0297
0.285
0.875
0.997
1.58e-08
NA
HCC70 AZD-6482 3 72
sigmoid
sigmoid
HCC70 AZD6482 0 3 72
 8 2.532
1.43
0.435
0.247
0.421
0.226
0.492
0.983
4.63e-06
NA
1.13
0.431
0.729
0.208
0.286
0.5
0.982
6.2e-06
NA
BT-549 Dactolisib 3 72
sigmoid
sigmoid
BT549 dactolisib 0 3 72
 8 1.801
0.0058
-0.00929
0.751
0.00579
0.000747
0.866
0.994
2.41e-07
NA
0.011
0.282
0.442
0.00425
0.29
0.909
0.995
1.54e-07
NA
HCC1806 GDC-0980 1 72
sigmoid
sigmoid
HCC1806 apitolisib 0 1 72
 8 2.696
1.24
0.339
0.152
0.739
0.223
1.15
0.995
1.52e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC1806 GDC-0980 3 72
sigmoid
sigmoid
HCC1806 apitolisib 0 3 72
 8 3.149
1.8
0.418
0.132
0.77
0.31
1.14
0.995
1.41e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC1806 GDC-0980 2 72
sigmoid
sigmoid
HCC1806 apitolisib 0 2 72
 8 2.781
1.32
0.355
0.148
0.746
0.241
1.15
0.995
1.49e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
BT-549 GDC-0980 3 72
sigmoid
sigmoid
BT549 apitolisib 0 3 72
 8 1.802
0.162
0.0283
0.377
0.158
0.0179
1.2
0.994
2.53e-07
NA
0.268
0.302
0.709
0.128
0.294
1.2
0.992
4.85e-07
NA
HCC38 GDC-0980 3 72
sigmoid
sigmoid
HCC38 apitolisib 0 3 72
 8 1.437
0.371
-0.0189
0.29
0.513
-0.179
0.946
0.993
3.35e-07
NA
0.96
0.359
0.808
0.393
0.295
0.998
0.993
3.51e-07
NA
HCC70 ZSTK474 1 72
sigmoid
sigmoid
HCC70 ZSTK474 0 1 72
 8 1.332
0.167
-0.265
0.366
0.201
-0.206
1.85
0.975
1.56e-05
NA
0.289
0.264
0.782
0.182
0.299
1.96
0.971
2.35e-05
NA
HCC38 Dactolisib 1 72
sigmoid
sigmoid
HCC38 dactolisib 0 1 72
 8 1.821
0.0109
-0.0403
0.672
0.0104
0.0212
0.892
0.985
3.44e-06
NA
0.0194
0.263
0.492
0.00757
0.301
0.975
0.988
1.65e-06
NA
BT-549 Dactolisib 1 72
sigmoid
sigmoid
BT549 dactolisib 0 1 72
 8 1.840
0.00961
-0.00769
0.683
0.00888
0.0384
1.01
0.985
3.53e-06
NA
0.0161
0.275
0.482
0.0068
0.303
1.09
0.987
2.38e-06
NA
HCC70 Pictilisib 3 72
sigmoid
sigmoid
HCC70 pictilisib 0 3 72
 8 2.450
1.32
0.305
0.102
0.938
0.225
1.76
0.983
4.73e-06
NA
1.28
0.351
0.901
0.766
0.303
1.81
0.973
2.06e-05
NA
BT-549 Dactolisib 2 72
sigmoid
sigmoid
BT549 dactolisib 0 2 72
 8 1.889
0.00968
-0.00862
0.677
0.00884
0.0542
1.27
0.985
3.3e-06
NA
0.0134
0.266
0.48
0.00701
0.305
1.45
0.988
1.53e-06
NA
HCC70 AZD-6482 1 72
sigmoid
sigmoid
HCC70 AZD6482 0 1 72
 8 1.368
0.0982
0.0128
0.462
0.205
-0.212
0.481
0.975
1.49e-05
NA
0.767
0.394
0.704
0.121
0.305
0.509
0.973
1.9e-05
NA